Association between single‐nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment
Aim This study aimed to investigate whether single‐nucleotide polymorphisms (SNPs) in the genes encoding 5‐HTR2A (5‐Hydroxytryptamine (serotonin) receptor 2A) and MTNR1A (melatonin receptor 1A) may contribute to postoperative pain perception after root canal treatment. We hypothesised that SNPs in H...
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| Veröffentlicht in: | International endodontic journal 2023-09, Vol.56 (9), p.1077-1091 |
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| creator | Meyfarth, Sandra Regina Santos Tavares, Jhenyfer da Silva Guimarães, Ludmila da Silva Silva, Erlange Andrade Borges Gaio, Daniella Cristina Ecker, Mainara Bassetto Brancher, João Armando Küchler, Erika Calvano Silva‐Sousa, Alice Corrêa Sousa‐Neto, Manoel Damião Antunes, Lívia Azeredo Alves Antunes, Leonardo Santos |
| description | Aim
This study aimed to investigate whether single‐nucleotide polymorphisms (SNPs) in the genes encoding 5‐HTR2A (5‐Hydroxytryptamine (serotonin) receptor 2A) and MTNR1A (melatonin receptor 1A) may contribute to postoperative pain perception after root canal treatment. We hypothesised that SNPs in HTR2A and MTNR1A genes were associated with postoperative pain after root canal treatment.
Methodology
This genetic cohort study enrolled patients with single‐rooted teeth diagnosed with pulp necrosis and asymptomatic apical periodontitis before root canal treatment. Root canal treatment was performed in one session using a standardized protocol. Postoperative pain and tenderness were assessed using a visual analogue scale (recorded every day for 7 days and on the 14th and 30th days after root canal treatment). Genomic DNA was extracted from saliva and used to genotype the SNPs in HTR2A (rs4941573 and rs6313) and MTNR1A (rs6553010, rs6847693 and rs13140012) using real‐time polymerase chain reaction. Genotypes were compared using univariate and multivariate Poisson regression with generalized estimating equations (p |
| doi_str_mv | 10.1111/iej.13946 |
| format | Article |
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This study aimed to investigate whether single‐nucleotide polymorphisms (SNPs) in the genes encoding 5‐HTR2A (5‐Hydroxytryptamine (serotonin) receptor 2A) and MTNR1A (melatonin receptor 1A) may contribute to postoperative pain perception after root canal treatment. We hypothesised that SNPs in HTR2A and MTNR1A genes were associated with postoperative pain after root canal treatment.
Methodology
This genetic cohort study enrolled patients with single‐rooted teeth diagnosed with pulp necrosis and asymptomatic apical periodontitis before root canal treatment. Root canal treatment was performed in one session using a standardized protocol. Postoperative pain and tenderness were assessed using a visual analogue scale (recorded every day for 7 days and on the 14th and 30th days after root canal treatment). Genomic DNA was extracted from saliva and used to genotype the SNPs in HTR2A (rs4941573 and rs6313) and MTNR1A (rs6553010, rs6847693 and rs13140012) using real‐time polymerase chain reaction. Genotypes were compared using univariate and multivariate Poisson regression with generalized estimating equations (p < .05).
Results
In total, 108 patients were enrolled in this study. The SNPs rs6553010 (MTNR1A), rs4941573 and rs6313 (HTR2A) were associated with an increased risk of developing pain after root canal treatment (p < .05).
Conclusions
This study suggests that SNPs in HTR2A and MTNR1A influence pain response after root canal treatment.</description><identifier>ISSN: 0143-2885</identifier><identifier>EISSN: 1365-2591</identifier><identifier>DOI: 10.1111/iej.13946</identifier><identifier>PMID: 37323077</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Dental pulp ; Endodontics ; genetic polymorphisms ; HTR2A ; Melatonin ; MTNR1A ; Pain ; Pain perception ; Periodontitis ; postoperative pain ; root canal treatment ; Root canals ; Saliva ; Serotonin ; Single-nucleotide polymorphism</subject><ispartof>International endodontic journal, 2023-09, Vol.56 (9), p.1077-1091</ispartof><rights>2023 British Endodontic Society. Published by John Wiley & Sons Ltd</rights><rights>2023 British Endodontic Society. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2023 International Endodontic Journal. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-162f51fa1eea19fae726ee68c5fb6d5ca017f4218aeed6f4c204e30ecff593a43</citedby><cites>FETCH-LOGICAL-c3536-162f51fa1eea19fae726ee68c5fb6d5ca017f4218aeed6f4c204e30ecff593a43</cites><orcidid>0000-0001-5351-2526 ; 0000-0002-2115-6958 ; 0000-0002-9931-0935 ; 0000-0002-7696-7600 ; 0000-0002-8432-0815</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiej.13946$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiej.13946$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37323077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyfarth, Sandra Regina Santos</creatorcontrib><creatorcontrib>Tavares, Jhenyfer da Silva</creatorcontrib><creatorcontrib>Guimarães, Ludmila da Silva</creatorcontrib><creatorcontrib>Silva, Erlange Andrade Borges</creatorcontrib><creatorcontrib>Gaio, Daniella Cristina</creatorcontrib><creatorcontrib>Ecker, Mainara Bassetto</creatorcontrib><creatorcontrib>Brancher, João Armando</creatorcontrib><creatorcontrib>Küchler, Erika Calvano</creatorcontrib><creatorcontrib>Silva‐Sousa, Alice Corrêa</creatorcontrib><creatorcontrib>Sousa‐Neto, Manoel Damião</creatorcontrib><creatorcontrib>Antunes, Lívia Azeredo Alves</creatorcontrib><creatorcontrib>Antunes, Leonardo Santos</creatorcontrib><title>Association between single‐nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment</title><title>International endodontic journal</title><addtitle>Int Endod J</addtitle><description>Aim
This study aimed to investigate whether single‐nucleotide polymorphisms (SNPs) in the genes encoding 5‐HTR2A (5‐Hydroxytryptamine (serotonin) receptor 2A) and MTNR1A (melatonin receptor 1A) may contribute to postoperative pain perception after root canal treatment. We hypothesised that SNPs in HTR2A and MTNR1A genes were associated with postoperative pain after root canal treatment.
Methodology
This genetic cohort study enrolled patients with single‐rooted teeth diagnosed with pulp necrosis and asymptomatic apical periodontitis before root canal treatment. Root canal treatment was performed in one session using a standardized protocol. Postoperative pain and tenderness were assessed using a visual analogue scale (recorded every day for 7 days and on the 14th and 30th days after root canal treatment). Genomic DNA was extracted from saliva and used to genotype the SNPs in HTR2A (rs4941573 and rs6313) and MTNR1A (rs6553010, rs6847693 and rs13140012) using real‐time polymerase chain reaction. Genotypes were compared using univariate and multivariate Poisson regression with generalized estimating equations (p < .05).
Results
In total, 108 patients were enrolled in this study. The SNPs rs6553010 (MTNR1A), rs4941573 and rs6313 (HTR2A) were associated with an increased risk of developing pain after root canal treatment (p < .05).
Conclusions
This study suggests that SNPs in HTR2A and MTNR1A influence pain response after root canal treatment.</description><subject>Dental pulp</subject><subject>Endodontics</subject><subject>genetic polymorphisms</subject><subject>HTR2A</subject><subject>Melatonin</subject><subject>MTNR1A</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Periodontitis</subject><subject>postoperative pain</subject><subject>root canal treatment</subject><subject>Root canals</subject><subject>Saliva</subject><subject>Serotonin</subject><subject>Single-nucleotide polymorphism</subject><issn>0143-2885</issn><issn>1365-2591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp10cFqFDEcBvAgil2rB19AAl70MG3-ySQze1xK1UrBi56HbOafmiWTjEmGsrc-gviIPonZbvVQMJcEvh8fgY-Q18DOoJ5zh7szEOtWPSErEEo2XK7hKVkxaEXD-16ekBc57xhjkgl4Tk5EJ7hgXbcivzY5R-N0cTHQLZZbxECzCzcef9_9DIvxGIsbkc7R76eY5u8uT5m6ijDFEkN9JTQ4l5go31AdRjqh148S2NAbDJjv81nXSNuCiaYYCzU6aE9LQl0mDOUleWa1z_jq4T4l3z5cfr341Fx_-Xh1sblujJBCNaC4lWA1IGpYW40dV4iqN9Ju1SiNZtDZlkOvEUdlW8NZi4KhsVauhW7FKXl37J1T_LFgLsPkskHvdcC45IH3vFYKaA_07SO6i0uqvz4oCcCUbFVV74_KpJhzQjvMyU067Qdgw2GooQ413A9V7ZuHxmU74fhP_l2mgvMjuHUe9_9vGq4uPx8r_wBgXKCz</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Meyfarth, Sandra Regina Santos</creator><creator>Tavares, Jhenyfer da Silva</creator><creator>Guimarães, Ludmila da Silva</creator><creator>Silva, Erlange Andrade Borges</creator><creator>Gaio, Daniella Cristina</creator><creator>Ecker, Mainara Bassetto</creator><creator>Brancher, João Armando</creator><creator>Küchler, Erika Calvano</creator><creator>Silva‐Sousa, Alice Corrêa</creator><creator>Sousa‐Neto, Manoel Damião</creator><creator>Antunes, Lívia Azeredo Alves</creator><creator>Antunes, Leonardo Santos</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5351-2526</orcidid><orcidid>https://orcid.org/0000-0002-2115-6958</orcidid><orcidid>https://orcid.org/0000-0002-9931-0935</orcidid><orcidid>https://orcid.org/0000-0002-7696-7600</orcidid><orcidid>https://orcid.org/0000-0002-8432-0815</orcidid></search><sort><creationdate>202309</creationdate><title>Association between single‐nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment</title><author>Meyfarth, Sandra Regina Santos ; Tavares, Jhenyfer da Silva ; Guimarães, Ludmila da Silva ; Silva, Erlange Andrade Borges ; Gaio, Daniella Cristina ; Ecker, Mainara Bassetto ; Brancher, João Armando ; Küchler, Erika Calvano ; Silva‐Sousa, Alice Corrêa ; Sousa‐Neto, Manoel Damião ; Antunes, Lívia Azeredo Alves ; Antunes, Leonardo Santos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-162f51fa1eea19fae726ee68c5fb6d5ca017f4218aeed6f4c204e30ecff593a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Dental pulp</topic><topic>Endodontics</topic><topic>genetic polymorphisms</topic><topic>HTR2A</topic><topic>Melatonin</topic><topic>MTNR1A</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Periodontitis</topic><topic>postoperative pain</topic><topic>root canal treatment</topic><topic>Root canals</topic><topic>Saliva</topic><topic>Serotonin</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyfarth, Sandra Regina Santos</creatorcontrib><creatorcontrib>Tavares, Jhenyfer da Silva</creatorcontrib><creatorcontrib>Guimarães, Ludmila da Silva</creatorcontrib><creatorcontrib>Silva, Erlange Andrade Borges</creatorcontrib><creatorcontrib>Gaio, Daniella Cristina</creatorcontrib><creatorcontrib>Ecker, Mainara Bassetto</creatorcontrib><creatorcontrib>Brancher, João Armando</creatorcontrib><creatorcontrib>Küchler, Erika Calvano</creatorcontrib><creatorcontrib>Silva‐Sousa, Alice Corrêa</creatorcontrib><creatorcontrib>Sousa‐Neto, Manoel Damião</creatorcontrib><creatorcontrib>Antunes, Lívia Azeredo Alves</creatorcontrib><creatorcontrib>Antunes, Leonardo Santos</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International endodontic journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyfarth, Sandra Regina Santos</au><au>Tavares, Jhenyfer da Silva</au><au>Guimarães, Ludmila da Silva</au><au>Silva, Erlange Andrade Borges</au><au>Gaio, Daniella Cristina</au><au>Ecker, Mainara Bassetto</au><au>Brancher, João Armando</au><au>Küchler, Erika Calvano</au><au>Silva‐Sousa, Alice Corrêa</au><au>Sousa‐Neto, Manoel Damião</au><au>Antunes, Lívia Azeredo Alves</au><au>Antunes, Leonardo Santos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between single‐nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment</atitle><jtitle>International endodontic journal</jtitle><addtitle>Int Endod J</addtitle><date>2023-09</date><risdate>2023</risdate><volume>56</volume><issue>9</issue><spage>1077</spage><epage>1091</epage><pages>1077-1091</pages><issn>0143-2885</issn><eissn>1365-2591</eissn><abstract>Aim
This study aimed to investigate whether single‐nucleotide polymorphisms (SNPs) in the genes encoding 5‐HTR2A (5‐Hydroxytryptamine (serotonin) receptor 2A) and MTNR1A (melatonin receptor 1A) may contribute to postoperative pain perception after root canal treatment. We hypothesised that SNPs in HTR2A and MTNR1A genes were associated with postoperative pain after root canal treatment.
Methodology
This genetic cohort study enrolled patients with single‐rooted teeth diagnosed with pulp necrosis and asymptomatic apical periodontitis before root canal treatment. Root canal treatment was performed in one session using a standardized protocol. Postoperative pain and tenderness were assessed using a visual analogue scale (recorded every day for 7 days and on the 14th and 30th days after root canal treatment). Genomic DNA was extracted from saliva and used to genotype the SNPs in HTR2A (rs4941573 and rs6313) and MTNR1A (rs6553010, rs6847693 and rs13140012) using real‐time polymerase chain reaction. Genotypes were compared using univariate and multivariate Poisson regression with generalized estimating equations (p < .05).
Results
In total, 108 patients were enrolled in this study. The SNPs rs6553010 (MTNR1A), rs4941573 and rs6313 (HTR2A) were associated with an increased risk of developing pain after root canal treatment (p < .05).
Conclusions
This study suggests that SNPs in HTR2A and MTNR1A influence pain response after root canal treatment.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37323077</pmid><doi>10.1111/iej.13946</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-5351-2526</orcidid><orcidid>https://orcid.org/0000-0002-2115-6958</orcidid><orcidid>https://orcid.org/0000-0002-9931-0935</orcidid><orcidid>https://orcid.org/0000-0002-7696-7600</orcidid><orcidid>https://orcid.org/0000-0002-8432-0815</orcidid></addata></record> |
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| identifier | ISSN: 0143-2885 |
| ispartof | International endodontic journal, 2023-09, Vol.56 (9), p.1077-1091 |
| issn | 0143-2885 1365-2591 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Dental pulp Endodontics genetic polymorphisms HTR2A Melatonin MTNR1A Pain Pain perception Periodontitis postoperative pain root canal treatment Root canals Saliva Serotonin Single-nucleotide polymorphism |
| title | Association between single‐nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment |
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