A Multifunctional Nanozyme with NADH Dehydrogenase-Like Activity and Nitric Oxide Release under Near-Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing
In recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need to develop new antibacterial agents to effectively treat AMR infection. Herein, a novel nanozyme platform (Cu,N-GQDs@Ru-NO) is prepared, where Cu,N-doped graphene quantum d...
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| Veröffentlicht in: | Advanced healthcare materials 2023-10, Vol.12 (25), p.e2300568-e2300568 |
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| creator | Wang, Yi Shi, Hong-Dong Zhang, Hai-Lin Yu Chen, Yu Ren, Bing Tang, Qi Sun, Qi Zhang, Qian-Ling Liu, Jin-Gang |
| description | In recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need to develop new antibacterial agents to effectively treat AMR infection. Herein, a novel nanozyme platform (Cu,N-GQDs@Ru-NO) is prepared, where Cu,N-doped graphene quantum dots (Cu,N-GQDs) are covalently functionalized with a nitric oxide (NO) donor, ruthenium nitrosyl (Ru-NO). Under 808 nm near-infrared (NIR) light irradiation, Cu,N-GQDs@Ru-NO demonstrates nicotinamide adenine dinucleotide (NADH) dehydrogenase-like activity for photo-oxidizing NADH to NAD
, thus disrupting the redox balance in bacterial cells and resulting in bacterial death; meanwhile, the onsite NIR light-delivered NO effectively eradicates the methicillin-resistant Staphylococcus aureus (MRSA) bacterial and biofilms, and promotes wound healing; furthermore, the nanozyme shows excellent photothermal effect that enhances the antibacterial efficacy as well. With the combination of NADH dehydrogenase activity, photothermal therapy, and NO gas therapy, the Cu,N-GQDs@Ru-NO nanozyme displays both in vitro and in vivo excellent efficacy for MRSA infection and biofilm eradication, which provides a new therapeutic modality for effectively treating MRSA inflammatory wounds. |
| doi_str_mv | 10.1002/adhm.202300568 |
| format | Article |
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, thus disrupting the redox balance in bacterial cells and resulting in bacterial death; meanwhile, the onsite NIR light-delivered NO effectively eradicates the methicillin-resistant Staphylococcus aureus (MRSA) bacterial and biofilms, and promotes wound healing; furthermore, the nanozyme shows excellent photothermal effect that enhances the antibacterial efficacy as well. With the combination of NADH dehydrogenase activity, photothermal therapy, and NO gas therapy, the Cu,N-GQDs@Ru-NO nanozyme displays both in vitro and in vivo excellent efficacy for MRSA infection and biofilm eradication, which provides a new therapeutic modality for effectively treating MRSA inflammatory wounds.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202300568</identifier><identifier>PMID: 37326411</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adenine ; Antibacterial agents ; Antimicrobial agents ; Antimicrobial resistance ; Bacteria ; Biofilms ; Dehydrogenases ; Drug resistance ; Effectiveness ; Graphene ; I.R. radiation ; Inflammation ; Light irradiation ; Methicillin ; NAD ; NADH ; NADH dehydrogenase ; Near infrared radiation ; Nicotinamide ; Nicotinamide adenine dinucleotide ; Nitric oxide ; Quantum dots ; Ruthenium ; Staphylococcus aureus ; Staphylococcus infections ; Wound healing ; Wound infection</subject><ispartof>Advanced healthcare materials, 2023-10, Vol.12 (25), p.e2300568-e2300568</ispartof><rights>2023 Wiley-VCH GmbH.</rights><rights>2023 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-d50e8e0ee4d08a94c486bdf8693b34cdc2efd07e93649d029a0cf562154d8e2a3</citedby><cites>FETCH-LOGICAL-c323t-d50e8e0ee4d08a94c486bdf8693b34cdc2efd07e93649d029a0cf562154d8e2a3</cites><orcidid>0000-0002-5690-8881</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37326411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Shi, Hong-Dong</creatorcontrib><creatorcontrib>Zhang, Hai-Lin</creatorcontrib><creatorcontrib>Yu Chen, Yu</creatorcontrib><creatorcontrib>Ren, Bing</creatorcontrib><creatorcontrib>Tang, Qi</creatorcontrib><creatorcontrib>Sun, Qi</creatorcontrib><creatorcontrib>Zhang, Qian-Ling</creatorcontrib><creatorcontrib>Liu, Jin-Gang</creatorcontrib><title>A Multifunctional Nanozyme with NADH Dehydrogenase-Like Activity and Nitric Oxide Release under Near-Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>In recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need to develop new antibacterial agents to effectively treat AMR infection. Herein, a novel nanozyme platform (Cu,N-GQDs@Ru-NO) is prepared, where Cu,N-doped graphene quantum dots (Cu,N-GQDs) are covalently functionalized with a nitric oxide (NO) donor, ruthenium nitrosyl (Ru-NO). Under 808 nm near-infrared (NIR) light irradiation, Cu,N-GQDs@Ru-NO demonstrates nicotinamide adenine dinucleotide (NADH) dehydrogenase-like activity for photo-oxidizing NADH to NAD
, thus disrupting the redox balance in bacterial cells and resulting in bacterial death; meanwhile, the onsite NIR light-delivered NO effectively eradicates the methicillin-resistant Staphylococcus aureus (MRSA) bacterial and biofilms, and promotes wound healing; furthermore, the nanozyme shows excellent photothermal effect that enhances the antibacterial efficacy as well. With the combination of NADH dehydrogenase activity, photothermal therapy, and NO gas therapy, the Cu,N-GQDs@Ru-NO nanozyme displays both in vitro and in vivo excellent efficacy for MRSA infection and biofilm eradication, which provides a new therapeutic modality for effectively treating MRSA inflammatory wounds.</description><subject>Adenine</subject><subject>Antibacterial agents</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial resistance</subject><subject>Bacteria</subject><subject>Biofilms</subject><subject>Dehydrogenases</subject><subject>Drug resistance</subject><subject>Effectiveness</subject><subject>Graphene</subject><subject>I.R. radiation</subject><subject>Inflammation</subject><subject>Light irradiation</subject><subject>Methicillin</subject><subject>NAD</subject><subject>NADH</subject><subject>NADH dehydrogenase</subject><subject>Near infrared radiation</subject><subject>Nicotinamide</subject><subject>Nicotinamide adenine dinucleotide</subject><subject>Nitric oxide</subject><subject>Quantum dots</subject><subject>Ruthenium</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Wound healing</subject><subject>Wound infection</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkc9v0zAUxyMEYtPYlSN6EhcuKf6RpM4x2gatVDppGuIYufZz45E4xXYG3d-5PwhXHT3giy29jz_v2d8se0_JjBLCPkvdDTNGGCekrMSr7JzRmuWsKuvXp3NBzrLLEB5IWlVJK0HfZmd8zlOF0vPsuYFvUx-tmZyKdnSyh7V049N-QPhtYwfr5noB19jttR-36GTAfGV_IjQJf7RxD9JpWNvorYLbP1Yj3GGPCYPJafSwRunzpTNeetSwstsuwtJ7qa089AMZkgFujLHKootw36GXO5xi8pnRQ-OiHazy48am2e4w2BClUwjJieqoSBP8GFM7WKDsrdu-y94Y2Qe8fNkvsu9fbu6vFvnq9uvyqlnlijMec10SFEgQC02ErAtViGqjjahqvuGF0oqh0WSONa-KWhNWS6JMWTFaFlogk_wi-3T07vz4a8IQ28EGhX0vHY5TaJlgc1YxLnhCP_6HPoyTT999oOapASuFSNTsSKX3huDRtDtvB-n3LSXtIfL2EHl7ijxd-PCinTYD6hP-L2D-F_K3qpM</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Wang, Yi</creator><creator>Shi, Hong-Dong</creator><creator>Zhang, Hai-Lin</creator><creator>Yu Chen, Yu</creator><creator>Ren, Bing</creator><creator>Tang, Qi</creator><creator>Sun, Qi</creator><creator>Zhang, Qian-Ling</creator><creator>Liu, Jin-Gang</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5690-8881</orcidid></search><sort><creationdate>20231001</creationdate><title>A Multifunctional Nanozyme with NADH Dehydrogenase-Like Activity and Nitric Oxide Release under Near-Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing</title><author>Wang, Yi ; Shi, Hong-Dong ; Zhang, Hai-Lin ; Yu Chen, Yu ; Ren, Bing ; Tang, Qi ; Sun, Qi ; Zhang, Qian-Ling ; Liu, Jin-Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-d50e8e0ee4d08a94c486bdf8693b34cdc2efd07e93649d029a0cf562154d8e2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adenine</topic><topic>Antibacterial agents</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial resistance</topic><topic>Bacteria</topic><topic>Biofilms</topic><topic>Dehydrogenases</topic><topic>Drug resistance</topic><topic>Effectiveness</topic><topic>Graphene</topic><topic>I.R. radiation</topic><topic>Inflammation</topic><topic>Light irradiation</topic><topic>Methicillin</topic><topic>NAD</topic><topic>NADH</topic><topic>NADH dehydrogenase</topic><topic>Near infrared radiation</topic><topic>Nicotinamide</topic><topic>Nicotinamide adenine dinucleotide</topic><topic>Nitric oxide</topic><topic>Quantum dots</topic><topic>Ruthenium</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus infections</topic><topic>Wound healing</topic><topic>Wound infection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Shi, Hong-Dong</creatorcontrib><creatorcontrib>Zhang, Hai-Lin</creatorcontrib><creatorcontrib>Yu Chen, Yu</creatorcontrib><creatorcontrib>Ren, Bing</creatorcontrib><creatorcontrib>Tang, Qi</creatorcontrib><creatorcontrib>Sun, Qi</creatorcontrib><creatorcontrib>Zhang, Qian-Ling</creatorcontrib><creatorcontrib>Liu, Jin-Gang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Immunology Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yi</au><au>Shi, Hong-Dong</au><au>Zhang, Hai-Lin</au><au>Yu Chen, Yu</au><au>Ren, Bing</au><au>Tang, Qi</au><au>Sun, Qi</au><au>Zhang, Qian-Ling</au><au>Liu, Jin-Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Multifunctional Nanozyme with NADH Dehydrogenase-Like Activity and Nitric Oxide Release under Near-Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv Healthc Mater</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>12</volume><issue>25</issue><spage>e2300568</spage><epage>e2300568</epage><pages>e2300568-e2300568</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>In recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need to develop new antibacterial agents to effectively treat AMR infection. Herein, a novel nanozyme platform (Cu,N-GQDs@Ru-NO) is prepared, where Cu,N-doped graphene quantum dots (Cu,N-GQDs) are covalently functionalized with a nitric oxide (NO) donor, ruthenium nitrosyl (Ru-NO). Under 808 nm near-infrared (NIR) light irradiation, Cu,N-GQDs@Ru-NO demonstrates nicotinamide adenine dinucleotide (NADH) dehydrogenase-like activity for photo-oxidizing NADH to NAD
, thus disrupting the redox balance in bacterial cells and resulting in bacterial death; meanwhile, the onsite NIR light-delivered NO effectively eradicates the methicillin-resistant Staphylococcus aureus (MRSA) bacterial and biofilms, and promotes wound healing; furthermore, the nanozyme shows excellent photothermal effect that enhances the antibacterial efficacy as well. With the combination of NADH dehydrogenase activity, photothermal therapy, and NO gas therapy, the Cu,N-GQDs@Ru-NO nanozyme displays both in vitro and in vivo excellent efficacy for MRSA infection and biofilm eradication, which provides a new therapeutic modality for effectively treating MRSA inflammatory wounds.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37326411</pmid><doi>10.1002/adhm.202300568</doi><orcidid>https://orcid.org/0000-0002-5690-8881</orcidid></addata></record> |
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| ispartof | Advanced healthcare materials, 2023-10, Vol.12 (25), p.e2300568-e2300568 |
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| subjects | Adenine Antibacterial agents Antimicrobial agents Antimicrobial resistance Bacteria Biofilms Dehydrogenases Drug resistance Effectiveness Graphene I.R. radiation Inflammation Light irradiation Methicillin NAD NADH NADH dehydrogenase Near infrared radiation Nicotinamide Nicotinamide adenine dinucleotide Nitric oxide Quantum dots Ruthenium Staphylococcus aureus Staphylococcus infections Wound healing Wound infection |
| title | A Multifunctional Nanozyme with NADH Dehydrogenase-Like Activity and Nitric Oxide Release under Near-Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing |
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