In acromegalic patients the serum levels of interleukin-33 and Resolvin D1 influence skin perfusion of hands: A pilot study
Acromegaly is a rare chronic disease, caused by the over-secretion of growth hormone (GH), that creates a pro-inflammatory state, but the exact mechanisms by which GH or insulin-like growth factor 1 (IGF-I) act on inflammatory cells are not fully understood. Aim of the study was to evaluate Interleu...
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| Veröffentlicht in: | Microvascular research 2023-09, Vol.149, p.104571-104571, Article 104571 |
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| creator | Costa, Denise Pellicano, Chiara Mercuri, Valeria Arnone, Jacopo Maria Rizzo, Flavio Leodori, Giorgia Gargiulo, Patrizia Rosato, Edoardo |
| description | Acromegaly is a rare chronic disease, caused by the over-secretion of growth hormone (GH), that creates a pro-inflammatory state, but the exact mechanisms by which GH or insulin-like growth factor 1 (IGF-I) act on inflammatory cells are not fully understood. Aim of the study was to evaluate Interleukin-33 (IL33) and D-series resolvins 1 (RvD1) and the skin perfusion of hands in patients with acromegaly (AP) and healthy controls (HC).
IL33 and RvD1 have been assessed in 20 AP and 20 HC. Nailfold videocapillaroscopy (NVC) was performed and skin perfusion of hands was assessed by laser speckle contrast analysis (LASCA) in both populations.
IL33 was significantly higher in AP compared to HC [73.08 pg/ml (IQR 47.11–100.80 pg/ml) vs 41.5 4 pg/ml (IQR 20.16–55.49 pg/ml), p |
| doi_str_mv | 10.1016/j.mvr.2023.104571 |
| format | Article |
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IL33 and RvD1 have been assessed in 20 AP and 20 HC. Nailfold videocapillaroscopy (NVC) was performed and skin perfusion of hands was assessed by laser speckle contrast analysis (LASCA) in both populations.
IL33 was significantly higher in AP compared to HC [73.08 pg/ml (IQR 47.11–100.80 pg/ml) vs 41.5 4 pg/ml (IQR 20.16–55.49 pg/ml), p < 0.05] and RvD1 was significantly lower in AP than HC [36.1 pg/ml (IQR 27.88–66.21 pg/ml) vs 60.01 pg/ml (IQR 46.88–74.69 pg/ml), p < 0.05]. At LASCA, peripheral blood perfusion (PBP) was significantly lower in AP compared to HC [56.66 pU (IQR 46.29–65.44 pU) vs 87 pU (IQR 80–98 pU), p < 0.001]. The median values of ROI1 and ROI3 were significantly lower in AP compared to HC [112.81 pU (IQR 83.36–121.69 pU) vs 131 pU (IQR 108–135 pU), p < 0.05] and [59.78 pU (IQR 46.84–79.75 pU) vs 85 pU (IQR 78–98 pU), p < 0.05], respectively. The proximal-distal gradient (PDG) was observed in 8 of 20 (40 %) AP.
Serum IL33 is higher in AP compared to HC; conversely, RvD1 is lower in AP compared to HC. Reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction.
•Acromegalic patients had higher serum level of IL33 than HC.•Acromegalic patients had lower serum level of RvD1 than HC.•Reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction.</description><identifier>ISSN: 0026-2862</identifier><identifier>EISSN: 1095-9319</identifier><identifier>DOI: 10.1016/j.mvr.2023.104571</identifier><identifier>PMID: 37321455</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acromegaly ; Acromegaly - diagnosis ; Acromegaly - metabolism ; Chronic inflammation ; D-series resolvins 1 ; Endothelial dysfunction ; Human Growth Hormone ; Humans ; Interleukin-33 ; LASCA ; NVC ; Perfusion ; Pilot Projects</subject><ispartof>Microvascular research, 2023-09, Vol.149, p.104571-104571, Article 104571</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-677193c4c282652534b027a62d96e12d09faac6254bd8d7126c2c49939d8dc7d3</citedby><cites>FETCH-LOGICAL-c396t-677193c4c282652534b027a62d96e12d09faac6254bd8d7126c2c49939d8dc7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026286223000973$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37321455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costa, Denise</creatorcontrib><creatorcontrib>Pellicano, Chiara</creatorcontrib><creatorcontrib>Mercuri, Valeria</creatorcontrib><creatorcontrib>Arnone, Jacopo Maria</creatorcontrib><creatorcontrib>Rizzo, Flavio</creatorcontrib><creatorcontrib>Leodori, Giorgia</creatorcontrib><creatorcontrib>Gargiulo, Patrizia</creatorcontrib><creatorcontrib>Rosato, Edoardo</creatorcontrib><title>In acromegalic patients the serum levels of interleukin-33 and Resolvin D1 influence skin perfusion of hands: A pilot study</title><title>Microvascular research</title><addtitle>Microvasc Res</addtitle><description>Acromegaly is a rare chronic disease, caused by the over-secretion of growth hormone (GH), that creates a pro-inflammatory state, but the exact mechanisms by which GH or insulin-like growth factor 1 (IGF-I) act on inflammatory cells are not fully understood. Aim of the study was to evaluate Interleukin-33 (IL33) and D-series resolvins 1 (RvD1) and the skin perfusion of hands in patients with acromegaly (AP) and healthy controls (HC).
IL33 and RvD1 have been assessed in 20 AP and 20 HC. Nailfold videocapillaroscopy (NVC) was performed and skin perfusion of hands was assessed by laser speckle contrast analysis (LASCA) in both populations.
IL33 was significantly higher in AP compared to HC [73.08 pg/ml (IQR 47.11–100.80 pg/ml) vs 41.5 4 pg/ml (IQR 20.16–55.49 pg/ml), p < 0.05] and RvD1 was significantly lower in AP than HC [36.1 pg/ml (IQR 27.88–66.21 pg/ml) vs 60.01 pg/ml (IQR 46.88–74.69 pg/ml), p < 0.05]. At LASCA, peripheral blood perfusion (PBP) was significantly lower in AP compared to HC [56.66 pU (IQR 46.29–65.44 pU) vs 87 pU (IQR 80–98 pU), p < 0.001]. The median values of ROI1 and ROI3 were significantly lower in AP compared to HC [112.81 pU (IQR 83.36–121.69 pU) vs 131 pU (IQR 108–135 pU), p < 0.05] and [59.78 pU (IQR 46.84–79.75 pU) vs 85 pU (IQR 78–98 pU), p < 0.05], respectively. The proximal-distal gradient (PDG) was observed in 8 of 20 (40 %) AP.
Serum IL33 is higher in AP compared to HC; conversely, RvD1 is lower in AP compared to HC. Reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction.
•Acromegalic patients had higher serum level of IL33 than HC.•Acromegalic patients had lower serum level of RvD1 than HC.•Reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction.</description><subject>Acromegaly</subject><subject>Acromegaly - diagnosis</subject><subject>Acromegaly - metabolism</subject><subject>Chronic inflammation</subject><subject>D-series resolvins 1</subject><subject>Endothelial dysfunction</subject><subject>Human Growth Hormone</subject><subject>Humans</subject><subject>Interleukin-33</subject><subject>LASCA</subject><subject>NVC</subject><subject>Perfusion</subject><subject>Pilot Projects</subject><issn>0026-2862</issn><issn>1095-9319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAURS1URIfCB7BBXnaTqf2cOGO6qgq0lSohIVhbHvuFenCcYDsjVfw8Hk3psqunq3fuXRxCPnC25ozLi9163Kc1MBA1t13PX5EVZ6prlODqhKwYA9nARsIpeZvzjjHOOwVvyKnoBfC261bk712kxqZpxF8meEtnUzzGkml5QJoxLSMNuMeQ6TRQHwumgMtvHxshqImOfsc8hb2P9DOv7yEsGG0tVoLOmIYl-ykeqg8Vzp_oFZ19mArNZXGP78jrwYSM75_uGfn59cuP69vm_tvN3fXVfWOFkqWRfc-VsK2FDcgOOtFuGfRGglMSOTimBmOshK7duo3rOUgLtlVKqBpt78QZOT_uzmn6s2AuevTZYggm4rRkXXd7qGLEpqL8iFYlOScc9Jz8aNKj5kwfnOudrs71wbk-Oq-dj0_zy3ZE99z4L7kCl0egasS9x6Sz9QdPzie0RbvJvzD_DyrxkcM</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Costa, Denise</creator><creator>Pellicano, Chiara</creator><creator>Mercuri, Valeria</creator><creator>Arnone, Jacopo Maria</creator><creator>Rizzo, Flavio</creator><creator>Leodori, Giorgia</creator><creator>Gargiulo, Patrizia</creator><creator>Rosato, Edoardo</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202309</creationdate><title>In acromegalic patients the serum levels of interleukin-33 and Resolvin D1 influence skin perfusion of hands: A pilot study</title><author>Costa, Denise ; Pellicano, Chiara ; Mercuri, Valeria ; Arnone, Jacopo Maria ; Rizzo, Flavio ; Leodori, Giorgia ; Gargiulo, Patrizia ; Rosato, Edoardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-677193c4c282652534b027a62d96e12d09faac6254bd8d7126c2c49939d8dc7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acromegaly</topic><topic>Acromegaly - diagnosis</topic><topic>Acromegaly - metabolism</topic><topic>Chronic inflammation</topic><topic>D-series resolvins 1</topic><topic>Endothelial dysfunction</topic><topic>Human Growth Hormone</topic><topic>Humans</topic><topic>Interleukin-33</topic><topic>LASCA</topic><topic>NVC</topic><topic>Perfusion</topic><topic>Pilot Projects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costa, Denise</creatorcontrib><creatorcontrib>Pellicano, Chiara</creatorcontrib><creatorcontrib>Mercuri, Valeria</creatorcontrib><creatorcontrib>Arnone, Jacopo Maria</creatorcontrib><creatorcontrib>Rizzo, Flavio</creatorcontrib><creatorcontrib>Leodori, Giorgia</creatorcontrib><creatorcontrib>Gargiulo, Patrizia</creatorcontrib><creatorcontrib>Rosato, Edoardo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microvascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costa, Denise</au><au>Pellicano, Chiara</au><au>Mercuri, Valeria</au><au>Arnone, Jacopo Maria</au><au>Rizzo, Flavio</au><au>Leodori, Giorgia</au><au>Gargiulo, Patrizia</au><au>Rosato, Edoardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In acromegalic patients the serum levels of interleukin-33 and Resolvin D1 influence skin perfusion of hands: A pilot study</atitle><jtitle>Microvascular research</jtitle><addtitle>Microvasc Res</addtitle><date>2023-09</date><risdate>2023</risdate><volume>149</volume><spage>104571</spage><epage>104571</epage><pages>104571-104571</pages><artnum>104571</artnum><issn>0026-2862</issn><eissn>1095-9319</eissn><abstract>Acromegaly is a rare chronic disease, caused by the over-secretion of growth hormone (GH), that creates a pro-inflammatory state, but the exact mechanisms by which GH or insulin-like growth factor 1 (IGF-I) act on inflammatory cells are not fully understood. Aim of the study was to evaluate Interleukin-33 (IL33) and D-series resolvins 1 (RvD1) and the skin perfusion of hands in patients with acromegaly (AP) and healthy controls (HC).
IL33 and RvD1 have been assessed in 20 AP and 20 HC. Nailfold videocapillaroscopy (NVC) was performed and skin perfusion of hands was assessed by laser speckle contrast analysis (LASCA) in both populations.
IL33 was significantly higher in AP compared to HC [73.08 pg/ml (IQR 47.11–100.80 pg/ml) vs 41.5 4 pg/ml (IQR 20.16–55.49 pg/ml), p < 0.05] and RvD1 was significantly lower in AP than HC [36.1 pg/ml (IQR 27.88–66.21 pg/ml) vs 60.01 pg/ml (IQR 46.88–74.69 pg/ml), p < 0.05]. At LASCA, peripheral blood perfusion (PBP) was significantly lower in AP compared to HC [56.66 pU (IQR 46.29–65.44 pU) vs 87 pU (IQR 80–98 pU), p < 0.001]. The median values of ROI1 and ROI3 were significantly lower in AP compared to HC [112.81 pU (IQR 83.36–121.69 pU) vs 131 pU (IQR 108–135 pU), p < 0.05] and [59.78 pU (IQR 46.84–79.75 pU) vs 85 pU (IQR 78–98 pU), p < 0.05], respectively. The proximal-distal gradient (PDG) was observed in 8 of 20 (40 %) AP.
Serum IL33 is higher in AP compared to HC; conversely, RvD1 is lower in AP compared to HC. Reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction.
•Acromegalic patients had higher serum level of IL33 than HC.•Acromegalic patients had lower serum level of RvD1 than HC.•Reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37321455</pmid><doi>10.1016/j.mvr.2023.104571</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acromegaly Acromegaly - diagnosis Acromegaly - metabolism Chronic inflammation D-series resolvins 1 Endothelial dysfunction Human Growth Hormone Humans Interleukin-33 LASCA NVC Perfusion Pilot Projects |
| title | In acromegalic patients the serum levels of interleukin-33 and Resolvin D1 influence skin perfusion of hands: A pilot study |
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