Presumptive identification of nitrite by Griess reagent test strips—Case reports of fatal poisoning with sodium nitrite
Abstract The intentional ingestion of sodium nitrite causes toxicity by inducing methemoglobinemia, which can lead to cyanosis, hypotension and death. The number of reported suicide cases has significantly increased in the past 10 years as sodium nitrite is readily available online. The traditional...
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| Veröffentlicht in: | Journal of analytical toxicology 2023-11, Vol.47 (8), p.746-749 |
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| container_issue | 8 |
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| container_title | Journal of analytical toxicology |
| container_volume | 47 |
| creator | Zhang, Man Truver, Michael T Hoyer, Jennifer L Chronister, Chris W Goldberger, Bruce A |
| description | Abstract
The intentional ingestion of sodium nitrite causes toxicity by inducing methemoglobinemia, which can lead to cyanosis, hypotension and death. The number of reported suicide cases has significantly increased in the past 10 years as sodium nitrite is readily available online. The traditional tests for nitrite and nitrate require specialized detection methods which are not typically available in a postmortem toxicology laboratory. This rise in sodium nitrite overdose cases indicates the need for a simple, quick test for suspected nitrite toxicity. In this study, a common Griess reagent color test (MQuant™ Nitrite Test Strips) was used as a presumptive method in cases where the ingestion of sodium nitrite was suspected. The test results were consistent between specimens in all cases, and vitreous humor was identified as a reliable matrix to be used in the cases of suspected sodium nitrite poisonings. Case reports of five patients who died of suicide by sodium nitrite in a 6-month span are presented. |
| doi_str_mv | 10.1093/jat/bkad038 |
| format | Article |
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The intentional ingestion of sodium nitrite causes toxicity by inducing methemoglobinemia, which can lead to cyanosis, hypotension and death. The number of reported suicide cases has significantly increased in the past 10 years as sodium nitrite is readily available online. The traditional tests for nitrite and nitrate require specialized detection methods which are not typically available in a postmortem toxicology laboratory. This rise in sodium nitrite overdose cases indicates the need for a simple, quick test for suspected nitrite toxicity. In this study, a common Griess reagent color test (MQuant™ Nitrite Test Strips) was used as a presumptive method in cases where the ingestion of sodium nitrite was suspected. The test results were consistent between specimens in all cases, and vitreous humor was identified as a reliable matrix to be used in the cases of suspected sodium nitrite poisonings. Case reports of five patients who died of suicide by sodium nitrite in a 6-month span are presented.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/bkad038</identifier><identifier>PMID: 37329300</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><ispartof>Journal of analytical toxicology, 2023-11, Vol.47 (8), p.746-749</ispartof><rights>Published by Oxford University Press 2023. This work is written by (a) US Government employee(s) and is in the public domain in the US. 2023</rights><rights>Published by Oxford University Press 2023. This work is written by (a) US Government employee(s) and is in the public domain in the US.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-e29e9858620d964830682c1d3a3864b0fb424c34cc874ec2eee21ab84a553e193</citedby><cites>FETCH-LOGICAL-c357t-e29e9858620d964830682c1d3a3864b0fb424c34cc874ec2eee21ab84a553e193</cites><orcidid>0000-0002-5799-1787 ; 0000-0003-3747-5379</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37329300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Man</creatorcontrib><creatorcontrib>Truver, Michael T</creatorcontrib><creatorcontrib>Hoyer, Jennifer L</creatorcontrib><creatorcontrib>Chronister, Chris W</creatorcontrib><creatorcontrib>Goldberger, Bruce A</creatorcontrib><title>Presumptive identification of nitrite by Griess reagent test strips—Case reports of fatal poisoning with sodium nitrite</title><title>Journal of analytical toxicology</title><addtitle>J Anal Toxicol</addtitle><description>Abstract
The intentional ingestion of sodium nitrite causes toxicity by inducing methemoglobinemia, which can lead to cyanosis, hypotension and death. The number of reported suicide cases has significantly increased in the past 10 years as sodium nitrite is readily available online. The traditional tests for nitrite and nitrate require specialized detection methods which are not typically available in a postmortem toxicology laboratory. This rise in sodium nitrite overdose cases indicates the need for a simple, quick test for suspected nitrite toxicity. In this study, a common Griess reagent color test (MQuant™ Nitrite Test Strips) was used as a presumptive method in cases where the ingestion of sodium nitrite was suspected. The test results were consistent between specimens in all cases, and vitreous humor was identified as a reliable matrix to be used in the cases of suspected sodium nitrite poisonings. Case reports of five patients who died of suicide by sodium nitrite in a 6-month span are presented.</description><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kM1O3DAQgK2qqCzQE_fKpwoJBfyXxDlWK_6klegBzpHjTBbTTRw8Dghx4SH6ADwLj9Inwe0uPXKaw3zzafQRss_ZEWeVPL418bj5ZVom9Scy45XKM6GY_ExmjKsiU2XBtskO4i1jvNCF_EK2ZSlFJRmbkaefAXDqx-jugboWhug6Z010fqC-e30ZXAwuAm0e6VlwgEgDmGXCaASMFNN2xD_Pv-cGIa1GHyL-O-xMNCs6eod-cMOSPrh4Q9G3burpRrpHtjqzQvi6mbvk-vTkan6eLS7PLuY_FpmVeRkzEBVUOteFYG1VKC1ZoYXlrTRSF6phXaOEslJZq0sFVgCA4KbRyuS5BF7JXXKw9o7B303p7bp3aGG1MgP4CWuhRSmSX-uEHq5RGzxigK4eg-tNeKw5q__WrlPtelM70d824qnpof3PvudNwPc14KfxQ9MbYtWN_w</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Zhang, Man</creator><creator>Truver, Michael T</creator><creator>Hoyer, Jennifer L</creator><creator>Chronister, Chris W</creator><creator>Goldberger, Bruce A</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5799-1787</orcidid><orcidid>https://orcid.org/0000-0003-3747-5379</orcidid></search><sort><creationdate>20231101</creationdate><title>Presumptive identification of nitrite by Griess reagent test strips—Case reports of fatal poisoning with sodium nitrite</title><author>Zhang, Man ; Truver, Michael T ; Hoyer, Jennifer L ; Chronister, Chris W ; Goldberger, Bruce A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-e29e9858620d964830682c1d3a3864b0fb424c34cc874ec2eee21ab84a553e193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Man</creatorcontrib><creatorcontrib>Truver, Michael T</creatorcontrib><creatorcontrib>Hoyer, Jennifer L</creatorcontrib><creatorcontrib>Chronister, Chris W</creatorcontrib><creatorcontrib>Goldberger, Bruce A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Man</au><au>Truver, Michael T</au><au>Hoyer, Jennifer L</au><au>Chronister, Chris W</au><au>Goldberger, Bruce A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presumptive identification of nitrite by Griess reagent test strips—Case reports of fatal poisoning with sodium nitrite</atitle><jtitle>Journal of analytical toxicology</jtitle><addtitle>J Anal Toxicol</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>47</volume><issue>8</issue><spage>746</spage><epage>749</epage><pages>746-749</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><abstract>Abstract
The intentional ingestion of sodium nitrite causes toxicity by inducing methemoglobinemia, which can lead to cyanosis, hypotension and death. The number of reported suicide cases has significantly increased in the past 10 years as sodium nitrite is readily available online. The traditional tests for nitrite and nitrate require specialized detection methods which are not typically available in a postmortem toxicology laboratory. This rise in sodium nitrite overdose cases indicates the need for a simple, quick test for suspected nitrite toxicity. In this study, a common Griess reagent color test (MQuant™ Nitrite Test Strips) was used as a presumptive method in cases where the ingestion of sodium nitrite was suspected. The test results were consistent between specimens in all cases, and vitreous humor was identified as a reliable matrix to be used in the cases of suspected sodium nitrite poisonings. Case reports of five patients who died of suicide by sodium nitrite in a 6-month span are presented.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>37329300</pmid><doi>10.1093/jat/bkad038</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-5799-1787</orcidid><orcidid>https://orcid.org/0000-0003-3747-5379</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of analytical toxicology, 2023-11, Vol.47 (8), p.746-749 |
| issn | 0146-4760 1945-2403 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | Presumptive identification of nitrite by Griess reagent test strips—Case reports of fatal poisoning with sodium nitrite |
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