Is cribriform pattern in prostate biopsy a risk factor for metastatic disease on 68Ga-PSMA-11 PET/CT?
Introduction Cribriform growth pattern (CP) in prostate cancer (PCa) has been associated with different unfavourable oncological outcomes. This study addresses if CP in prostate biopsies is an independent risk factor for metastatic disease on PSMA PET/CT. Methods Treatment-naive patients with ISUP G...
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| Veröffentlicht in: | World journal of urology 2023-08, Vol.41 (8), p.2165-2171 |
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| creator | Heetman, J. G. Versteeg, R. Wever, L. Paulino Pereira, L. J. Soeterik, T. F. W. Lavalaye, J. de Bruin, P. C. van den Bergh, R. C. N. van Melick, H. H. E. |
| description | Introduction
Cribriform growth pattern (CP) in prostate cancer (PCa) has been associated with different unfavourable oncological outcomes. This study addresses if CP in prostate biopsies is an independent risk factor for metastatic disease on PSMA PET/CT.
Methods
Treatment-naive patients with ISUP GG ≥ 2 staged with
68
Ga-PSMA-11 PET/CT diagnosed from 2020 to 2021 were retrospectively enrolled. To test if CP in biopsies was an independent risk factor for metastatic disease on
68
Ga-PSMA PET/CT, regression analyses were performed. Secondary analyses were performed in different subgroups.
Results
A total of 401 patients were included. CP was reported in 252 (63%) patients. CP in biopsies was not an independent risk factor for metastatic disease on the
68
Ga-PSMA PET/CT (
p
= 0.14). ISUP grade group (GG) 4 (
p
= 0.006), GG 5 (
p
= 0.003), higher PSA level groups per 10 ng/ml until > 50 (
p
-value between 0.02 and > 0.001) and clinical EPE (
p
> 0.001) were all independent risk factors. In the subgroups with GG 2 (
n
= 99), GG 3 (
n
= 110), intermediate-risk group (
n
= 129) or the high-risk group (
n
= 272), CP in biopsies was also not an independent risk factor for metastatic disease on
68
Ga-PSMA PET/CT. If the EAU guideline recommendation for performing metastatic screening was applied as threshold for PSMA PET/CT imaging, in 9(2%) patients, metastatic disease was missed, and 18% fewer PSMA PET/CT would have been performed.
Conclusion
This retrospective study found that CP in biopsies was not an independent risk factor for metastatic disease on 68Ga-PSMA PET/CT. |
| doi_str_mv | 10.1007/s00345-023-04467-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2827257242</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2848589966</sourcerecordid><originalsourceid>FETCH-LOGICAL-c233t-fe23fe69d1bb3f604d53455a391d91ff1b4143dc525b88c4be1d0b1ecdec052c3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhhdRsFb_gKeAFy-x-dyPk5RSa6FiwXoO2exEUru7Ndke2l9v6gqKB08zh-d9mXmS5JqSO0pINgqEcCExYRwTIdIMH06SARWc4zxj6emv_Ty5CGFNCM1SIgcJzAMy3pXe2dbXaKu7DnyDXIO2vg2d7gCVrt2GPdLIu_COrDZd61GkUQ2dPiLOoMoF0AFQ26A0n2m8fHkaY0rRcroaTVb3l8mZ1ZsAV99zmLw-TFeTR7x4ns0n4wU2jPMOW2DcQlpUtCy5TYmoZPxKal7QqqDW0lLEPyojmSzz3IgSaEVKCqYCQyQzfJjc9r3x-I8dhE7VLhjYbHQD7S4olrOMyYwJFtGbP-i63fkmXhcpkcu8KNI0UqynTLQRPFi19a7Wfq8oUUfzqjevonn1ZV4dYoj3oRDh5g38T_U_qU-8jYWN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2848589966</pqid></control><display><type>article</type><title>Is cribriform pattern in prostate biopsy a risk factor for metastatic disease on 68Ga-PSMA-11 PET/CT?</title><source>SpringerLink Journals</source><creator>Heetman, J. G. ; Versteeg, R. ; Wever, L. ; Paulino Pereira, L. J. ; Soeterik, T. F. W. ; Lavalaye, J. ; de Bruin, P. C. ; van den Bergh, R. C. N. ; van Melick, H. H. E.</creator><creatorcontrib>Heetman, J. G. ; Versteeg, R. ; Wever, L. ; Paulino Pereira, L. J. ; Soeterik, T. F. W. ; Lavalaye, J. ; de Bruin, P. C. ; van den Bergh, R. C. N. ; van Melick, H. H. E.</creatorcontrib><description>Introduction
Cribriform growth pattern (CP) in prostate cancer (PCa) has been associated with different unfavourable oncological outcomes. This study addresses if CP in prostate biopsies is an independent risk factor for metastatic disease on PSMA PET/CT.
Methods
Treatment-naive patients with ISUP GG ≥ 2 staged with
68
Ga-PSMA-11 PET/CT diagnosed from 2020 to 2021 were retrospectively enrolled. To test if CP in biopsies was an independent risk factor for metastatic disease on
68
Ga-PSMA PET/CT, regression analyses were performed. Secondary analyses were performed in different subgroups.
Results
A total of 401 patients were included. CP was reported in 252 (63%) patients. CP in biopsies was not an independent risk factor for metastatic disease on the
68
Ga-PSMA PET/CT (
p
= 0.14). ISUP grade group (GG) 4 (
p
= 0.006), GG 5 (
p
= 0.003), higher PSA level groups per 10 ng/ml until > 50 (
p
-value between 0.02 and > 0.001) and clinical EPE (
p
> 0.001) were all independent risk factors. In the subgroups with GG 2 (
n
= 99), GG 3 (
n
= 110), intermediate-risk group (
n
= 129) or the high-risk group (
n
= 272), CP in biopsies was also not an independent risk factor for metastatic disease on
68
Ga-PSMA PET/CT. If the EAU guideline recommendation for performing metastatic screening was applied as threshold for PSMA PET/CT imaging, in 9(2%) patients, metastatic disease was missed, and 18% fewer PSMA PET/CT would have been performed.
Conclusion
This retrospective study found that CP in biopsies was not an independent risk factor for metastatic disease on 68Ga-PSMA PET/CT.</description><identifier>ISSN: 1433-8726</identifier><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-023-04467-z</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biopsy ; Computed tomography ; Growth patterns ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Nephrology ; Oncology ; Original Article ; Patients ; Positron emission tomography ; Prostate cancer ; Risk factors ; Risk groups ; Urology</subject><ispartof>World journal of urology, 2023-08, Vol.41 (8), p.2165-2171</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c233t-fe23fe69d1bb3f604d53455a391d91ff1b4143dc525b88c4be1d0b1ecdec052c3</cites><orcidid>0000-0002-9560-7387</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-023-04467-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-023-04467-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Heetman, J. G.</creatorcontrib><creatorcontrib>Versteeg, R.</creatorcontrib><creatorcontrib>Wever, L.</creatorcontrib><creatorcontrib>Paulino Pereira, L. J.</creatorcontrib><creatorcontrib>Soeterik, T. F. W.</creatorcontrib><creatorcontrib>Lavalaye, J.</creatorcontrib><creatorcontrib>de Bruin, P. C.</creatorcontrib><creatorcontrib>van den Bergh, R. C. N.</creatorcontrib><creatorcontrib>van Melick, H. H. E.</creatorcontrib><title>Is cribriform pattern in prostate biopsy a risk factor for metastatic disease on 68Ga-PSMA-11 PET/CT?</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><description>Introduction
Cribriform growth pattern (CP) in prostate cancer (PCa) has been associated with different unfavourable oncological outcomes. This study addresses if CP in prostate biopsies is an independent risk factor for metastatic disease on PSMA PET/CT.
Methods
Treatment-naive patients with ISUP GG ≥ 2 staged with
68
Ga-PSMA-11 PET/CT diagnosed from 2020 to 2021 were retrospectively enrolled. To test if CP in biopsies was an independent risk factor for metastatic disease on
68
Ga-PSMA PET/CT, regression analyses were performed. Secondary analyses were performed in different subgroups.
Results
A total of 401 patients were included. CP was reported in 252 (63%) patients. CP in biopsies was not an independent risk factor for metastatic disease on the
68
Ga-PSMA PET/CT (
p
= 0.14). ISUP grade group (GG) 4 (
p
= 0.006), GG 5 (
p
= 0.003), higher PSA level groups per 10 ng/ml until > 50 (
p
-value between 0.02 and > 0.001) and clinical EPE (
p
> 0.001) were all independent risk factors. In the subgroups with GG 2 (
n
= 99), GG 3 (
n
= 110), intermediate-risk group (
n
= 129) or the high-risk group (
n
= 272), CP in biopsies was also not an independent risk factor for metastatic disease on
68
Ga-PSMA PET/CT. If the EAU guideline recommendation for performing metastatic screening was applied as threshold for PSMA PET/CT imaging, in 9(2%) patients, metastatic disease was missed, and 18% fewer PSMA PET/CT would have been performed.
Conclusion
This retrospective study found that CP in biopsies was not an independent risk factor for metastatic disease on 68Ga-PSMA PET/CT.</description><subject>Biopsy</subject><subject>Computed tomography</subject><subject>Growth patterns</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Positron emission tomography</subject><subject>Prostate cancer</subject><subject>Risk factors</subject><subject>Risk groups</subject><subject>Urology</subject><issn>1433-8726</issn><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE1LAzEQhhdRsFb_gKeAFy-x-dyPk5RSa6FiwXoO2exEUru7Ndke2l9v6gqKB08zh-d9mXmS5JqSO0pINgqEcCExYRwTIdIMH06SARWc4zxj6emv_Ty5CGFNCM1SIgcJzAMy3pXe2dbXaKu7DnyDXIO2vg2d7gCVrt2GPdLIu_COrDZd61GkUQ2dPiLOoMoF0AFQ26A0n2m8fHkaY0rRcroaTVb3l8mZ1ZsAV99zmLw-TFeTR7x4ns0n4wU2jPMOW2DcQlpUtCy5TYmoZPxKal7QqqDW0lLEPyojmSzz3IgSaEVKCqYCQyQzfJjc9r3x-I8dhE7VLhjYbHQD7S4olrOMyYwJFtGbP-i63fkmXhcpkcu8KNI0UqynTLQRPFi19a7Wfq8oUUfzqjevonn1ZV4dYoj3oRDh5g38T_U_qU-8jYWN</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Heetman, J. G.</creator><creator>Versteeg, R.</creator><creator>Wever, L.</creator><creator>Paulino Pereira, L. J.</creator><creator>Soeterik, T. F. W.</creator><creator>Lavalaye, J.</creator><creator>de Bruin, P. C.</creator><creator>van den Bergh, R. C. N.</creator><creator>van Melick, H. H. E.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9560-7387</orcidid></search><sort><creationdate>20230801</creationdate><title>Is cribriform pattern in prostate biopsy a risk factor for metastatic disease on 68Ga-PSMA-11 PET/CT?</title><author>Heetman, J. G. ; Versteeg, R. ; Wever, L. ; Paulino Pereira, L. J. ; Soeterik, T. F. W. ; Lavalaye, J. ; de Bruin, P. C. ; van den Bergh, R. C. N. ; van Melick, H. H. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c233t-fe23fe69d1bb3f604d53455a391d91ff1b4143dc525b88c4be1d0b1ecdec052c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biopsy</topic><topic>Computed tomography</topic><topic>Growth patterns</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Nephrology</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Positron emission tomography</topic><topic>Prostate cancer</topic><topic>Risk factors</topic><topic>Risk groups</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heetman, J. G.</creatorcontrib><creatorcontrib>Versteeg, R.</creatorcontrib><creatorcontrib>Wever, L.</creatorcontrib><creatorcontrib>Paulino Pereira, L. J.</creatorcontrib><creatorcontrib>Soeterik, T. F. W.</creatorcontrib><creatorcontrib>Lavalaye, J.</creatorcontrib><creatorcontrib>de Bruin, P. C.</creatorcontrib><creatorcontrib>van den Bergh, R. C. N.</creatorcontrib><creatorcontrib>van Melick, H. H. E.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heetman, J. G.</au><au>Versteeg, R.</au><au>Wever, L.</au><au>Paulino Pereira, L. J.</au><au>Soeterik, T. F. W.</au><au>Lavalaye, J.</au><au>de Bruin, P. C.</au><au>van den Bergh, R. C. N.</au><au>van Melick, H. H. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is cribriform pattern in prostate biopsy a risk factor for metastatic disease on 68Ga-PSMA-11 PET/CT?</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><date>2023-08-01</date><risdate>2023</risdate><volume>41</volume><issue>8</issue><spage>2165</spage><epage>2171</epage><pages>2165-2171</pages><issn>1433-8726</issn><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Introduction
Cribriform growth pattern (CP) in prostate cancer (PCa) has been associated with different unfavourable oncological outcomes. This study addresses if CP in prostate biopsies is an independent risk factor for metastatic disease on PSMA PET/CT.
Methods
Treatment-naive patients with ISUP GG ≥ 2 staged with
68
Ga-PSMA-11 PET/CT diagnosed from 2020 to 2021 were retrospectively enrolled. To test if CP in biopsies was an independent risk factor for metastatic disease on
68
Ga-PSMA PET/CT, regression analyses were performed. Secondary analyses were performed in different subgroups.
Results
A total of 401 patients were included. CP was reported in 252 (63%) patients. CP in biopsies was not an independent risk factor for metastatic disease on the
68
Ga-PSMA PET/CT (
p
= 0.14). ISUP grade group (GG) 4 (
p
= 0.006), GG 5 (
p
= 0.003), higher PSA level groups per 10 ng/ml until > 50 (
p
-value between 0.02 and > 0.001) and clinical EPE (
p
> 0.001) were all independent risk factors. In the subgroups with GG 2 (
n
= 99), GG 3 (
n
= 110), intermediate-risk group (
n
= 129) or the high-risk group (
n
= 272), CP in biopsies was also not an independent risk factor for metastatic disease on
68
Ga-PSMA PET/CT. If the EAU guideline recommendation for performing metastatic screening was applied as threshold for PSMA PET/CT imaging, in 9(2%) patients, metastatic disease was missed, and 18% fewer PSMA PET/CT would have been performed.
Conclusion
This retrospective study found that CP in biopsies was not an independent risk factor for metastatic disease on 68Ga-PSMA PET/CT.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00345-023-04467-z</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9560-7387</orcidid></addata></record> |
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| subjects | Biopsy Computed tomography Growth patterns Medicine Medicine & Public Health Metastases Metastasis Nephrology Oncology Original Article Patients Positron emission tomography Prostate cancer Risk factors Risk groups Urology |
| title | Is cribriform pattern in prostate biopsy a risk factor for metastatic disease on 68Ga-PSMA-11 PET/CT? |
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