Alginate/chitosan hydrogels as perspective transport systems for cefotaxime
This work reports synthesis of pH-responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefot...
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| Veröffentlicht in: | Biopolymers 2023-10, Vol.114 (10), p.e23555-e23555 |
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| creator | Shilova, Svetlana V Mirgaleev, Grigory M Romanova, Ksenia A Galyametdinov, Yury G |
| description | This work reports synthesis of pH-responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefotaxime from the spheres in the media that simulate human biological fluids in peroral delivery conditions was found to be a pH-dependent process. The analysis of cefotaxime release kinetics by the Korsmeyer-Peppas model revealed a non-Fickian mechanism of its diffusion, which may be related to intermolecular interactions occurring between the antibiotic and chitosan. Conductometry, UV spectroscopy, and IR spectroscopy were used to study complexation of chitosan with cefotaxime in aqueous media with varied pH, characterize the composition of the complexes, and calculate their stability constants. The composition of the cefotaxime-chitosan complexes was found to correspond to the 1.0:4.0 and 1.0:2.0 molar ratios of the components at pH 2.0 and 5.6, respectively. Quantum chemical modeling was used to evaluate energy characteristics of chitosan-cefotaxime complexation considering the influence of a solvent. |
| doi_str_mv | 10.1002/bip.23555 |
| format | Article |
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The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefotaxime from the spheres in the media that simulate human biological fluids in peroral delivery conditions was found to be a pH-dependent process. The analysis of cefotaxime release kinetics by the Korsmeyer-Peppas model revealed a non-Fickian mechanism of its diffusion, which may be related to intermolecular interactions occurring between the antibiotic and chitosan. Conductometry, UV spectroscopy, and IR spectroscopy were used to study complexation of chitosan with cefotaxime in aqueous media with varied pH, characterize the composition of the complexes, and calculate their stability constants. The composition of the cefotaxime-chitosan complexes was found to correspond to the 1.0:4.0 and 1.0:2.0 molar ratios of the components at pH 2.0 and 5.6, respectively. Quantum chemical modeling was used to evaluate energy characteristics of chitosan-cefotaxime complexation considering the influence of a solvent.</description><identifier>ISSN: 0006-3525</identifier><identifier>EISSN: 1097-0282</identifier><identifier>DOI: 10.1002/bip.23555</identifier><identifier>PMID: 37318946</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Alginates ; Alginic acid ; Antibiotics ; Aqueous solutions ; Cefotaxime ; Chitosan ; Complexation ; Composition ; Hydrogels ; Infrared spectroscopy ; pH effects ; Quantum chemistry ; Spectrum analysis ; Stability constants ; Transportation systems</subject><ispartof>Biopolymers, 2023-10, Vol.114 (10), p.e23555-e23555</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c273t-80d59d9f7e1991f7751db9ff4a94f969e8262ea91eb344647b3f8424d68288223</cites><orcidid>0000-0002-0887-8251</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37318946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shilova, Svetlana V</creatorcontrib><creatorcontrib>Mirgaleev, Grigory M</creatorcontrib><creatorcontrib>Romanova, Ksenia A</creatorcontrib><creatorcontrib>Galyametdinov, Yury G</creatorcontrib><title>Alginate/chitosan hydrogels as perspective transport systems for cefotaxime</title><title>Biopolymers</title><addtitle>Biopolymers</addtitle><description>This work reports synthesis of pH-responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. 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Quantum chemical modeling was used to evaluate energy characteristics of chitosan-cefotaxime complexation considering the influence of a solvent.</description><subject>Alginates</subject><subject>Alginic acid</subject><subject>Antibiotics</subject><subject>Aqueous solutions</subject><subject>Cefotaxime</subject><subject>Chitosan</subject><subject>Complexation</subject><subject>Composition</subject><subject>Hydrogels</subject><subject>Infrared spectroscopy</subject><subject>pH effects</subject><subject>Quantum chemistry</subject><subject>Spectrum analysis</subject><subject>Stability constants</subject><subject>Transportation systems</subject><issn>0006-3525</issn><issn>1097-0282</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpd0D1PwzAQgGELgWgpDPwBFIkFhrT-jO2xqvgSlVhgjpzk3KZK4mC7iP57Ai0MTLc8Ot29CF0SPCUY01lR91PKhBBHaEywlimmih6jMcY4S5mgYoTOQthgzDkj-BSNmGREaZ6N0fO8WdWdiTAr13V0wXTJeld5t4ImJCYkPfjQQxnrD0iiN13onY9J2IUIbUis80kJ1kXzWbdwjk6saQJcHOYEvd3fvS4e0-XLw9NivkxLKllMFa6ErrSVQLQmVkpBqkJby43mVmcaFM0oGE2gYJxnXBbMKk55lSmqFKVsgm72e3vv3rcQYt7WoYSmMR24bciH5yUVmWRqoNf_6MZtfTdcNyhJhOBasEHd7lXpXQgebN77ujV-lxOcfxfOh8L5T-HBXh02bosWqj_5m5R9AQ3ldbU</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Shilova, Svetlana V</creator><creator>Mirgaleev, Grigory M</creator><creator>Romanova, Ksenia A</creator><creator>Galyametdinov, Yury G</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0887-8251</orcidid></search><sort><creationdate>20231001</creationdate><title>Alginate/chitosan hydrogels as perspective transport systems for cefotaxime</title><author>Shilova, Svetlana V ; Mirgaleev, Grigory M ; Romanova, Ksenia A ; Galyametdinov, Yury G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-80d59d9f7e1991f7751db9ff4a94f969e8262ea91eb344647b3f8424d68288223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alginates</topic><topic>Alginic acid</topic><topic>Antibiotics</topic><topic>Aqueous solutions</topic><topic>Cefotaxime</topic><topic>Chitosan</topic><topic>Complexation</topic><topic>Composition</topic><topic>Hydrogels</topic><topic>Infrared spectroscopy</topic><topic>pH effects</topic><topic>Quantum chemistry</topic><topic>Spectrum analysis</topic><topic>Stability constants</topic><topic>Transportation systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shilova, Svetlana V</creatorcontrib><creatorcontrib>Mirgaleev, Grigory M</creatorcontrib><creatorcontrib>Romanova, Ksenia A</creatorcontrib><creatorcontrib>Galyametdinov, Yury G</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biopolymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shilova, Svetlana V</au><au>Mirgaleev, Grigory M</au><au>Romanova, Ksenia A</au><au>Galyametdinov, Yury G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alginate/chitosan hydrogels as perspective transport systems for cefotaxime</atitle><jtitle>Biopolymers</jtitle><addtitle>Biopolymers</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>114</volume><issue>10</issue><spage>e23555</spage><epage>e23555</epage><pages>e23555-e23555</pages><issn>0006-3525</issn><eissn>1097-0282</eissn><abstract>This work reports synthesis of pH-responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefotaxime from the spheres in the media that simulate human biological fluids in peroral delivery conditions was found to be a pH-dependent process. The analysis of cefotaxime release kinetics by the Korsmeyer-Peppas model revealed a non-Fickian mechanism of its diffusion, which may be related to intermolecular interactions occurring between the antibiotic and chitosan. Conductometry, UV spectroscopy, and IR spectroscopy were used to study complexation of chitosan with cefotaxime in aqueous media with varied pH, characterize the composition of the complexes, and calculate their stability constants. The composition of the cefotaxime-chitosan complexes was found to correspond to the 1.0:4.0 and 1.0:2.0 molar ratios of the components at pH 2.0 and 5.6, respectively. 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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Alginates Alginic acid Antibiotics Aqueous solutions Cefotaxime Chitosan Complexation Composition Hydrogels Infrared spectroscopy pH effects Quantum chemistry Spectrum analysis Stability constants Transportation systems |
| title | Alginate/chitosan hydrogels as perspective transport systems for cefotaxime |
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