Prevalence and grade of malignancy differences with respect to the area of involvement in multiparametric resonance imaging of the prostate in the diagnosis of prostate cancer using the PI-RADS version 2 classification
Purpose The peripheral zone is histologically different from the transitional zone. The aim of this study is to analyze the differences between the prevalence and grade of malignancy of mpMRI-targeted biopsies that involve the TZ with respect to the PZ. Methods A cross-sectional study of 597 men eva...
Gespeichert in:
| Veröffentlicht in: | World journal of urology 2023-08, Vol.41 (8), p.2155-2163 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2163 |
|---|---|
| container_issue | 8 |
| container_start_page | 2155 |
| container_title | World journal of urology |
| container_volume | 41 |
| creator | Rodríguez-Cabello, Miguel Angel Méndez-Rubio, Santiago Sanz-Miguelañez, Juan Luis Moraga-Sanz, Alvaro Aulló-González, Carolina Platas-Sancho, Arturo |
| description | Purpose
The peripheral zone is histologically different from the transitional zone. The aim of this study is to analyze the differences between the prevalence and grade of malignancy of mpMRI-targeted biopsies that involve the TZ with respect to the PZ.
Methods
A cross-sectional study of 597 men evaluated for PC screening between February 2016 and October 2022 was conducted. Exclusion criteria were prior BPH surgery, radiotherapy, 5-alpha-reductase inhibitors treatment, UTI, mixed involvement of PZ–TZ or doubts, and central-zone involvement. Hypothesis contrast test was used to study differences proportions of malignancy (ISUP > 0) and significant (ISUP > 1) and high-grade tumor (ISUP > 3) in PI-RADSv2 > 2-targeted biopsies in PZ with respect to TZ, and logistic regression and hypothesis contrast tests were used to study the influence of the area of exposure as an effect-modifying factor in the diagnosis of malignancy with respect to the PI-RADSv2 classification.
Results
473 patients were selected and 573 lesions biopsied (127 PI-RADS3, 346 PI-RADS4 and 100 PI-RADS5). A significant increase was described in the proportion of malignancy and significant and high-grade tumor in PZ compared to TZ (22.6%, 21.3%, and 8.7%, respectively). Significant increase in proportions and malignancy were described in cores targeted to PZ with respect to TZ, highlight the differences between PZ and TZ for ST (37.3%vs23.7% for PI-RADS4, 69.2%vs27.3% for PI-RADS5, respectively). Statistically significant linear trend was described increasing for malignancy, significant and high-grade tumors with respect to the PI-RADSv2 scores (change > 10%).
Conclusion
Although the prevalence and grade of malignancy in the TZ is lower than in the PZ, PI-RADS4 and 5-targeted biopsies should not be omitted in this location, but PI-RADS3 could be. |
| doi_str_mv | 10.1007/s00345-023-04466-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2827255595</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2827255595</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-595a8a40dfa8a89cb721b2270d0f6666983ae8527bb5f079ab299a3587441d383</originalsourceid><addsrcrecordid>eNp9kctu1TAURSMEoqXwAwyQJSZMAo4fsTOsWh6VKlHxGFsnzknqKnEutnNRf5WvweaWghiQie14rW0nu6qeN_R1Q6l6EynlQtaU8ZoK0bY1fVAdN4LzWivWPvxrflQ9ifGG0ka1VD6ujrjirG2lOK5-XAXcw4zeIgE_kCnAgGQdyQKzmzx4e0sGN44YChLJd5euScC4Q5tIWkm6zl5AKIrz-3Xe44I-5TlZtjm5HQRYMAVni7WWQCRugcn5qTjF34U1JkhYpLIeHEx-jS4W4H7TFjWQLRazYFcX9afT889kjyG61RNG7AwxutFZSPnF0-rRCHPEZ3fjSfX13dsvZx_qy4_vL85OL2vLlUy17CRoEHQY86A72yvW9IwpOtCxzU-nOaCWTPW9HKnqoGddB1xqJUQzcM1PqleH3HzVbxvGZBYXLc4zeFy3aJhmikmZz8noy3_Qm3ULPt8uU0JL3ammBLIDZfO3x4Cj2YX8y8KtaagpzZtD8yY3b341b2iWXtxFb_2Cw73yu-oM8AMQ85afMPw5-z-xPwGUL7zb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2848589718</pqid></control><display><type>article</type><title>Prevalence and grade of malignancy differences with respect to the area of involvement in multiparametric resonance imaging of the prostate in the diagnosis of prostate cancer using the PI-RADS version 2 classification</title><source>SpringerLink Journals - AutoHoldings</source><creator>Rodríguez-Cabello, Miguel Angel ; Méndez-Rubio, Santiago ; Sanz-Miguelañez, Juan Luis ; Moraga-Sanz, Alvaro ; Aulló-González, Carolina ; Platas-Sancho, Arturo</creator><creatorcontrib>Rodríguez-Cabello, Miguel Angel ; Méndez-Rubio, Santiago ; Sanz-Miguelañez, Juan Luis ; Moraga-Sanz, Alvaro ; Aulló-González, Carolina ; Platas-Sancho, Arturo</creatorcontrib><description>Purpose
The peripheral zone is histologically different from the transitional zone. The aim of this study is to analyze the differences between the prevalence and grade of malignancy of mpMRI-targeted biopsies that involve the TZ with respect to the PZ.
Methods
A cross-sectional study of 597 men evaluated for PC screening between February 2016 and October 2022 was conducted. Exclusion criteria were prior BPH surgery, radiotherapy, 5-alpha-reductase inhibitors treatment, UTI, mixed involvement of PZ–TZ or doubts, and central-zone involvement. Hypothesis contrast test was used to study differences proportions of malignancy (ISUP > 0) and significant (ISUP > 1) and high-grade tumor (ISUP > 3) in PI-RADSv2 > 2-targeted biopsies in PZ with respect to TZ, and logistic regression and hypothesis contrast tests were used to study the influence of the area of exposure as an effect-modifying factor in the diagnosis of malignancy with respect to the PI-RADSv2 classification.
Results
473 patients were selected and 573 lesions biopsied (127 PI-RADS3, 346 PI-RADS4 and 100 PI-RADS5). A significant increase was described in the proportion of malignancy and significant and high-grade tumor in PZ compared to TZ (22.6%, 21.3%, and 8.7%, respectively). Significant increase in proportions and malignancy were described in cores targeted to PZ with respect to TZ, highlight the differences between PZ and TZ for ST (37.3%vs23.7% for PI-RADS4, 69.2%vs27.3% for PI-RADS5, respectively). Statistically significant linear trend was described increasing for malignancy, significant and high-grade tumors with respect to the PI-RADSv2 scores (change > 10%).
Conclusion
Although the prevalence and grade of malignancy in the TZ is lower than in the PZ, PI-RADS4 and 5-targeted biopsies should not be omitted in this location, but PI-RADS3 could be.</description><identifier>ISSN: 1433-8726</identifier><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-023-04466-0</identifier><identifier>PMID: 37326654</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biopsy ; Classification ; Diagnosis ; Hypotheses ; Malignancy ; Medicine ; Medicine & Public Health ; Nephrology ; Oncology ; Original Article ; Prostate ; Prostate cancer ; Radiation therapy ; Statistical analysis ; Tumors ; Urology</subject><ispartof>World journal of urology, 2023-08, Vol.41 (8), p.2155-2163</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-595a8a40dfa8a89cb721b2270d0f6666983ae8527bb5f079ab299a3587441d383</citedby><cites>FETCH-LOGICAL-c375t-595a8a40dfa8a89cb721b2270d0f6666983ae8527bb5f079ab299a3587441d383</cites><orcidid>0000-0003-3716-7093</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-023-04466-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-023-04466-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37326654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez-Cabello, Miguel Angel</creatorcontrib><creatorcontrib>Méndez-Rubio, Santiago</creatorcontrib><creatorcontrib>Sanz-Miguelañez, Juan Luis</creatorcontrib><creatorcontrib>Moraga-Sanz, Alvaro</creatorcontrib><creatorcontrib>Aulló-González, Carolina</creatorcontrib><creatorcontrib>Platas-Sancho, Arturo</creatorcontrib><title>Prevalence and grade of malignancy differences with respect to the area of involvement in multiparametric resonance imaging of the prostate in the diagnosis of prostate cancer using the PI-RADS version 2 classification</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose
The peripheral zone is histologically different from the transitional zone. The aim of this study is to analyze the differences between the prevalence and grade of malignancy of mpMRI-targeted biopsies that involve the TZ with respect to the PZ.
Methods
A cross-sectional study of 597 men evaluated for PC screening between February 2016 and October 2022 was conducted. Exclusion criteria were prior BPH surgery, radiotherapy, 5-alpha-reductase inhibitors treatment, UTI, mixed involvement of PZ–TZ or doubts, and central-zone involvement. Hypothesis contrast test was used to study differences proportions of malignancy (ISUP > 0) and significant (ISUP > 1) and high-grade tumor (ISUP > 3) in PI-RADSv2 > 2-targeted biopsies in PZ with respect to TZ, and logistic regression and hypothesis contrast tests were used to study the influence of the area of exposure as an effect-modifying factor in the diagnosis of malignancy with respect to the PI-RADSv2 classification.
Results
473 patients were selected and 573 lesions biopsied (127 PI-RADS3, 346 PI-RADS4 and 100 PI-RADS5). A significant increase was described in the proportion of malignancy and significant and high-grade tumor in PZ compared to TZ (22.6%, 21.3%, and 8.7%, respectively). Significant increase in proportions and malignancy were described in cores targeted to PZ with respect to TZ, highlight the differences between PZ and TZ for ST (37.3%vs23.7% for PI-RADS4, 69.2%vs27.3% for PI-RADS5, respectively). Statistically significant linear trend was described increasing for malignancy, significant and high-grade tumors with respect to the PI-RADSv2 scores (change > 10%).
Conclusion
Although the prevalence and grade of malignancy in the TZ is lower than in the PZ, PI-RADS4 and 5-targeted biopsies should not be omitted in this location, but PI-RADS3 could be.</description><subject>Biopsy</subject><subject>Classification</subject><subject>Diagnosis</subject><subject>Hypotheses</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Radiation therapy</subject><subject>Statistical analysis</subject><subject>Tumors</subject><subject>Urology</subject><issn>1433-8726</issn><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctu1TAURSMEoqXwAwyQJSZMAo4fsTOsWh6VKlHxGFsnzknqKnEutnNRf5WvweaWghiQie14rW0nu6qeN_R1Q6l6EynlQtaU8ZoK0bY1fVAdN4LzWivWPvxrflQ9ifGG0ka1VD6ujrjirG2lOK5-XAXcw4zeIgE_kCnAgGQdyQKzmzx4e0sGN44YChLJd5euScC4Q5tIWkm6zl5AKIrz-3Xe44I-5TlZtjm5HQRYMAVni7WWQCRugcn5qTjF34U1JkhYpLIeHEx-jS4W4H7TFjWQLRazYFcX9afT889kjyG61RNG7AwxutFZSPnF0-rRCHPEZ3fjSfX13dsvZx_qy4_vL85OL2vLlUy17CRoEHQY86A72yvW9IwpOtCxzU-nOaCWTPW9HKnqoGddB1xqJUQzcM1PqleH3HzVbxvGZBYXLc4zeFy3aJhmikmZz8noy3_Qm3ULPt8uU0JL3ammBLIDZfO3x4Cj2YX8y8KtaagpzZtD8yY3b341b2iWXtxFb_2Cw73yu-oM8AMQ85afMPw5-z-xPwGUL7zb</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Rodríguez-Cabello, Miguel Angel</creator><creator>Méndez-Rubio, Santiago</creator><creator>Sanz-Miguelañez, Juan Luis</creator><creator>Moraga-Sanz, Alvaro</creator><creator>Aulló-González, Carolina</creator><creator>Platas-Sancho, Arturo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3716-7093</orcidid></search><sort><creationdate>20230801</creationdate><title>Prevalence and grade of malignancy differences with respect to the area of involvement in multiparametric resonance imaging of the prostate in the diagnosis of prostate cancer using the PI-RADS version 2 classification</title><author>Rodríguez-Cabello, Miguel Angel ; Méndez-Rubio, Santiago ; Sanz-Miguelañez, Juan Luis ; Moraga-Sanz, Alvaro ; Aulló-González, Carolina ; Platas-Sancho, Arturo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-595a8a40dfa8a89cb721b2270d0f6666983ae8527bb5f079ab299a3587441d383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biopsy</topic><topic>Classification</topic><topic>Diagnosis</topic><topic>Hypotheses</topic><topic>Malignancy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Radiation therapy</topic><topic>Statistical analysis</topic><topic>Tumors</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez-Cabello, Miguel Angel</creatorcontrib><creatorcontrib>Méndez-Rubio, Santiago</creatorcontrib><creatorcontrib>Sanz-Miguelañez, Juan Luis</creatorcontrib><creatorcontrib>Moraga-Sanz, Alvaro</creatorcontrib><creatorcontrib>Aulló-González, Carolina</creatorcontrib><creatorcontrib>Platas-Sancho, Arturo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez-Cabello, Miguel Angel</au><au>Méndez-Rubio, Santiago</au><au>Sanz-Miguelañez, Juan Luis</au><au>Moraga-Sanz, Alvaro</au><au>Aulló-González, Carolina</au><au>Platas-Sancho, Arturo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and grade of malignancy differences with respect to the area of involvement in multiparametric resonance imaging of the prostate in the diagnosis of prostate cancer using the PI-RADS version 2 classification</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>41</volume><issue>8</issue><spage>2155</spage><epage>2163</epage><pages>2155-2163</pages><issn>1433-8726</issn><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Purpose
The peripheral zone is histologically different from the transitional zone. The aim of this study is to analyze the differences between the prevalence and grade of malignancy of mpMRI-targeted biopsies that involve the TZ with respect to the PZ.
Methods
A cross-sectional study of 597 men evaluated for PC screening between February 2016 and October 2022 was conducted. Exclusion criteria were prior BPH surgery, radiotherapy, 5-alpha-reductase inhibitors treatment, UTI, mixed involvement of PZ–TZ or doubts, and central-zone involvement. Hypothesis contrast test was used to study differences proportions of malignancy (ISUP > 0) and significant (ISUP > 1) and high-grade tumor (ISUP > 3) in PI-RADSv2 > 2-targeted biopsies in PZ with respect to TZ, and logistic regression and hypothesis contrast tests were used to study the influence of the area of exposure as an effect-modifying factor in the diagnosis of malignancy with respect to the PI-RADSv2 classification.
Results
473 patients were selected and 573 lesions biopsied (127 PI-RADS3, 346 PI-RADS4 and 100 PI-RADS5). A significant increase was described in the proportion of malignancy and significant and high-grade tumor in PZ compared to TZ (22.6%, 21.3%, and 8.7%, respectively). Significant increase in proportions and malignancy were described in cores targeted to PZ with respect to TZ, highlight the differences between PZ and TZ for ST (37.3%vs23.7% for PI-RADS4, 69.2%vs27.3% for PI-RADS5, respectively). Statistically significant linear trend was described increasing for malignancy, significant and high-grade tumors with respect to the PI-RADSv2 scores (change > 10%).
Conclusion
Although the prevalence and grade of malignancy in the TZ is lower than in the PZ, PI-RADS4 and 5-targeted biopsies should not be omitted in this location, but PI-RADS3 could be.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37326654</pmid><doi>10.1007/s00345-023-04466-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3716-7093</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1433-8726 |
| ispartof | World journal of urology, 2023-08, Vol.41 (8), p.2155-2163 |
| issn | 1433-8726 0724-4983 1433-8726 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2827255595 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Biopsy Classification Diagnosis Hypotheses Malignancy Medicine Medicine & Public Health Nephrology Oncology Original Article Prostate Prostate cancer Radiation therapy Statistical analysis Tumors Urology |
| title | Prevalence and grade of malignancy differences with respect to the area of involvement in multiparametric resonance imaging of the prostate in the diagnosis of prostate cancer using the PI-RADS version 2 classification |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T07%3A04%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20grade%20of%20malignancy%20differences%20with%20respect%20to%20the%20area%20of%20involvement%20in%20multiparametric%20resonance%20imaging%20of%20the%20prostate%20in%20the%20diagnosis%20of%20prostate%20cancer%20using%20the%20PI-RADS%20version%202%20classification&rft.jtitle=World%20journal%20of%20urology&rft.au=Rodr%C3%ADguez-Cabello,%20Miguel%20Angel&rft.date=2023-08-01&rft.volume=41&rft.issue=8&rft.spage=2155&rft.epage=2163&rft.pages=2155-2163&rft.issn=1433-8726&rft.eissn=1433-8726&rft_id=info:doi/10.1007/s00345-023-04466-0&rft_dat=%3Cproquest_cross%3E2827255595%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2848589718&rft_id=info:pmid/37326654&rfr_iscdi=true |