Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia

[Display omitted] •A series of indolone derivatives were designed, synthesized, and evaluated as novel FLT3 inhibitors.•Compound LC-3 exhibited potent antiproliferative activity against FLT3-ITD positive AML cells.•Compound LC-3 significantly suppressed the tumor growth in MV-4-11 xenograft models....

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Veröffentlicht in:	Bioorganic chemistry 2023-09, Vol.138, p.106645-106645, Article 106645
Hauptverfasser:	Jin, Jiaming, Cui, Zhenzhen, Lv, Cheng, Peng, Xuemei, Yan, Zhiqi, Song, Yi, Cao, Yu, Zhou, Wenyi, Wang, Enpeng, Chen, Xufan, Kang, Di, Hu, Lihong, Wang, Junwei
Format:	Artikel
Sprache:	eng
Schlagworte:	AML Apoptosis Cell Line, Tumor Cell Proliferation Drug Discovery FLT3 inhibitors FLT3-ITD fms-Like Tyrosine Kinase 3 - metabolism Humans Indolone derivatives Leukemia, Myeloid, Acute - pathology Mutation Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Signal Transduction
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