Mutagenic potentials of dental cements as detected by the Salmonella/microsome test
The potential mutagenicity of a zinc phosphate (Poscal ®), a polycarboxylate (Aqualox ®) and glass ionomer cements with (Argion ®) and without (Meron ®) silver reinforcement were characterized by employing the Ames Salmonella/microsome test. The materials were eluted in dimethyl sulphoxide or physio...
Gespeichert in:
| Veröffentlicht in: | Biomaterials 2004-08, Vol.25 (18), p.4019-4027 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4027 |
|---|---|
| container_issue | 18 |
| container_start_page | 4019 |
| container_title | Biomaterials |
| container_volume | 25 |
| creator | Kaplan, Çiǧdem Diril, Nuran Şahin, Saime Cehreli, Murat Cavit |
| description | The potential mutagenicity of a zinc phosphate (Poscal
®), a polycarboxylate (Aqualox
®) and glass ionomer cements with (Argion
®) and without (Meron
®) silver reinforcement were characterized by employing the Ames
Salmonella/microsome test. The materials were eluted in dimethyl sulphoxide or physiologic saline and the aliquots were used either immediately or after an incubation period of 24
h at 37°C. Mutagenic effects of the materials were tested on
Salmonella typhimurium strains TA 98, TA 100, TA 102 and TA 1535 using the standard plate incorporation assay, and in the presence or absence of S9 fraction from rat liver. Poscal
® and Aqualox
® elicited mutagenic effects on
S. typhimurium TA 98 and TA 1535, whereas Meron
® exhibited mutagenic effects on
S. typhimurium TA 98. No mutagenic effects were detected for Argion
®. The type of solvent, dose of the material and incubation as well as the interactions between these factors exhibited varying degrees of influences on the mutagenic activities of the cements (
P |
| doi_str_mv | 10.1016/j.biomaterials.2003.10.101 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_28268973</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0142961203010482</els_id><sourcerecordid>28268973</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-397627316248b08f983c845115c7afc64766b70546419e617246881f8654b05c3</originalsourceid><addsrcrecordid>eNqNkE1PxCAQhonR6PrxFwzx4K0rUArUm_E7WeNBPRNKp8qmLWuhJvvvpdlN9KYnhpl33pl5EDqjZE4JFRfLeeV8ZyIMzrRhzgjJ55vaDppRJVVWlKTYRTNCOctKQdkBOgxhSdKfcLaPDmhBuFAlm6GXpzGad-idxSsfoY-TJfYNrlNsWmyhS0HAJqRMBBuhxtUaxw_AL6btfA9tay46ZwcffAc4QojHaK9JLnCyfY_Q293t6_VDtni-f7y-WmSW5ypmeSkFkzkVjKuKqKZUuVW8oLSw0jRWcClEJUnBBaclCCpZ2lnRRomCV6Sw-RE63_iuBv85psG6c8FOC_Xgx6CZYulImf8ppFLRUnCVhJcb4XROGKDRq8F1ZlhrSvTEXi_1b_Z6Yr-tpebT7ZSx6qD-ad3CToKbjQASlC8Hgw7WQW-hdkMiq2vv_jPnG7V9mtY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17819648</pqid></control><display><type>article</type><title>Mutagenic potentials of dental cements as detected by the Salmonella/microsome test</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kaplan, Çiǧdem ; Diril, Nuran ; Şahin, Saime ; Cehreli, Murat Cavit</creator><creatorcontrib>Kaplan, Çiǧdem ; Diril, Nuran ; Şahin, Saime ; Cehreli, Murat Cavit</creatorcontrib><description>The potential mutagenicity of a zinc phosphate (Poscal
®), a polycarboxylate (Aqualox
®) and glass ionomer cements with (Argion
®) and without (Meron
®) silver reinforcement were characterized by employing the Ames
Salmonella/microsome test. The materials were eluted in dimethyl sulphoxide or physiologic saline and the aliquots were used either immediately or after an incubation period of 24
h at 37°C. Mutagenic effects of the materials were tested on
Salmonella typhimurium strains TA 98, TA 100, TA 102 and TA 1535 using the standard plate incorporation assay, and in the presence or absence of S9 fraction from rat liver. Poscal
® and Aqualox
® elicited mutagenic effects on
S. typhimurium TA 98 and TA 1535, whereas Meron
® exhibited mutagenic effects on
S. typhimurium TA 98. No mutagenic effects were detected for Argion
®. The type of solvent, dose of the material and incubation as well as the interactions between these factors exhibited varying degrees of influences on the mutagenic activities of the cements (
P<0.05 and
P<0.1). We conclude that zinc phosphate, polycarboxylate, and glass ionomer cements may have possible mutagenic activities.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2003.10.101</identifier><identifier>PMID: 15046892</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Ames test ; Animals ; Dental cements ; Dental Cements - toxicity ; Dose-Response Relationship, Drug ; Male ; Materials Testing - methods ; Microsomes, Liver - drug effects ; Microsomes, Liver - microbiology ; Mutagenicity ; Mutagenicity Tests - methods ; Rats ; Rats, Sprague-Dawley ; Salmonella typhimurium ; Salmonella typhimurium - cytology ; Salmonella typhimurium - drug effects ; Salmonella typhimurium - genetics ; Silver - toxicity</subject><ispartof>Biomaterials, 2004-08, Vol.25 (18), p.4019-4027</ispartof><rights>2003 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-397627316248b08f983c845115c7afc64766b70546419e617246881f8654b05c3</citedby><cites>FETCH-LOGICAL-c438t-397627316248b08f983c845115c7afc64766b70546419e617246881f8654b05c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961203010482$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15046892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaplan, Çiǧdem</creatorcontrib><creatorcontrib>Diril, Nuran</creatorcontrib><creatorcontrib>Şahin, Saime</creatorcontrib><creatorcontrib>Cehreli, Murat Cavit</creatorcontrib><title>Mutagenic potentials of dental cements as detected by the Salmonella/microsome test</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>The potential mutagenicity of a zinc phosphate (Poscal
®), a polycarboxylate (Aqualox
®) and glass ionomer cements with (Argion
®) and without (Meron
®) silver reinforcement were characterized by employing the Ames
Salmonella/microsome test. The materials were eluted in dimethyl sulphoxide or physiologic saline and the aliquots were used either immediately or after an incubation period of 24
h at 37°C. Mutagenic effects of the materials were tested on
Salmonella typhimurium strains TA 98, TA 100, TA 102 and TA 1535 using the standard plate incorporation assay, and in the presence or absence of S9 fraction from rat liver. Poscal
® and Aqualox
® elicited mutagenic effects on
S. typhimurium TA 98 and TA 1535, whereas Meron
® exhibited mutagenic effects on
S. typhimurium TA 98. No mutagenic effects were detected for Argion
®. The type of solvent, dose of the material and incubation as well as the interactions between these factors exhibited varying degrees of influences on the mutagenic activities of the cements (
P<0.05 and
P<0.1). We conclude that zinc phosphate, polycarboxylate, and glass ionomer cements may have possible mutagenic activities.</description><subject>Ames test</subject><subject>Animals</subject><subject>Dental cements</subject><subject>Dental Cements - toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Male</subject><subject>Materials Testing - methods</subject><subject>Microsomes, Liver - drug effects</subject><subject>Microsomes, Liver - microbiology</subject><subject>Mutagenicity</subject><subject>Mutagenicity Tests - methods</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - cytology</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Salmonella typhimurium - genetics</subject><subject>Silver - toxicity</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PxCAQhonR6PrxFwzx4K0rUArUm_E7WeNBPRNKp8qmLWuhJvvvpdlN9KYnhpl33pl5EDqjZE4JFRfLeeV8ZyIMzrRhzgjJ55vaDppRJVVWlKTYRTNCOctKQdkBOgxhSdKfcLaPDmhBuFAlm6GXpzGad-idxSsfoY-TJfYNrlNsWmyhS0HAJqRMBBuhxtUaxw_AL6btfA9tay46ZwcffAc4QojHaK9JLnCyfY_Q293t6_VDtni-f7y-WmSW5ypmeSkFkzkVjKuKqKZUuVW8oLSw0jRWcClEJUnBBaclCCpZ2lnRRomCV6Sw-RE63_iuBv85psG6c8FOC_Xgx6CZYulImf8ppFLRUnCVhJcb4XROGKDRq8F1ZlhrSvTEXi_1b_Z6Yr-tpebT7ZSx6qD-ad3CToKbjQASlC8Hgw7WQW-hdkMiq2vv_jPnG7V9mtY</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Kaplan, Çiǧdem</creator><creator>Diril, Nuran</creator><creator>Şahin, Saime</creator><creator>Cehreli, Murat Cavit</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>JG9</scope></search><sort><creationdate>20040801</creationdate><title>Mutagenic potentials of dental cements as detected by the Salmonella/microsome test</title><author>Kaplan, Çiǧdem ; Diril, Nuran ; Şahin, Saime ; Cehreli, Murat Cavit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-397627316248b08f983c845115c7afc64766b70546419e617246881f8654b05c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Ames test</topic><topic>Animals</topic><topic>Dental cements</topic><topic>Dental Cements - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Male</topic><topic>Materials Testing - methods</topic><topic>Microsomes, Liver - drug effects</topic><topic>Microsomes, Liver - microbiology</topic><topic>Mutagenicity</topic><topic>Mutagenicity Tests - methods</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium - cytology</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Salmonella typhimurium - genetics</topic><topic>Silver - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaplan, Çiǧdem</creatorcontrib><creatorcontrib>Diril, Nuran</creatorcontrib><creatorcontrib>Şahin, Saime</creatorcontrib><creatorcontrib>Cehreli, Murat Cavit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Materials Research Database</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaplan, Çiǧdem</au><au>Diril, Nuran</au><au>Şahin, Saime</au><au>Cehreli, Murat Cavit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutagenic potentials of dental cements as detected by the Salmonella/microsome test</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>25</volume><issue>18</issue><spage>4019</spage><epage>4027</epage><pages>4019-4027</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>The potential mutagenicity of a zinc phosphate (Poscal
®), a polycarboxylate (Aqualox
®) and glass ionomer cements with (Argion
®) and without (Meron
®) silver reinforcement were characterized by employing the Ames
Salmonella/microsome test. The materials were eluted in dimethyl sulphoxide or physiologic saline and the aliquots were used either immediately or after an incubation period of 24
h at 37°C. Mutagenic effects of the materials were tested on
Salmonella typhimurium strains TA 98, TA 100, TA 102 and TA 1535 using the standard plate incorporation assay, and in the presence or absence of S9 fraction from rat liver. Poscal
® and Aqualox
® elicited mutagenic effects on
S. typhimurium TA 98 and TA 1535, whereas Meron
® exhibited mutagenic effects on
S. typhimurium TA 98. No mutagenic effects were detected for Argion
®. The type of solvent, dose of the material and incubation as well as the interactions between these factors exhibited varying degrees of influences on the mutagenic activities of the cements (
P<0.05 and
P<0.1). We conclude that zinc phosphate, polycarboxylate, and glass ionomer cements may have possible mutagenic activities.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>15046892</pmid><doi>10.1016/j.biomaterials.2003.10.101</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2004-08, Vol.25 (18), p.4019-4027 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_28268973 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Ames test Animals Dental cements Dental Cements - toxicity Dose-Response Relationship, Drug Male Materials Testing - methods Microsomes, Liver - drug effects Microsomes, Liver - microbiology Mutagenicity Mutagenicity Tests - methods Rats Rats, Sprague-Dawley Salmonella typhimurium Salmonella typhimurium - cytology Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Silver - toxicity |
| title | Mutagenic potentials of dental cements as detected by the Salmonella/microsome test |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T06%3A43%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mutagenic%20potentials%20of%20dental%20cements%20as%20detected%20by%20the%20Salmonella/microsome%20test&rft.jtitle=Biomaterials&rft.au=Kaplan,%20%C3%87i%C7%A7dem&rft.date=2004-08-01&rft.volume=25&rft.issue=18&rft.spage=4019&rft.epage=4027&rft.pages=4019-4027&rft.issn=0142-9612&rft.eissn=1878-5905&rft_id=info:doi/10.1016/j.biomaterials.2003.10.101&rft_dat=%3Cproquest_cross%3E28268973%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17819648&rft_id=info:pmid/15046892&rft_els_id=S0142961203010482&rfr_iscdi=true |