An antibody-radionuclide conjugate targets fibroblast activation protein for cancer therapy

Purpose Fibroblast activation protein is one of the most attractive targets for tumor diagnosis and therapy. There have been many successful clinical translations with small molecules and peptides, yet only a few anti-FAP antibody diagnostic or therapeutic agents have been reported. Antibodies often...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2023-09, Vol.50 (11), p.3214-3224
Hauptverfasser:	Xu, Mengxin, Chen, Junyi, Zhang, Pu, Cai, Jie, Song, Hanbo, Li, Zhu, Liu, Zhibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Antibodies Biodistribution Cancer Cancer therapies Cardiology Cell Line, Tumor Conjugates Conjugation Fibroblast activation protein Fibroblasts Imaging Immunoconjugates - therapeutic use Lutetium isotopes Medical imaging Medicine Medicine & Public Health Mice Neoplasms - diagnostic imaging Neoplasms - drug therapy Neoplasms - radiotherapy Nuclear Medicine Oncology Original Article Orthopedics Peptides Pharmaceuticals Pharmacokinetics Pharmacology Positron emission Positron-Emission Tomography - methods Proteins Radiation therapy Radioactivity Radiochemistry Radioisotopes Radioisotopes - chemistry Radioisotopes - therapeutic use Radiology Radiopharmaceuticals - pharmacokinetics Radiopharmaceuticals - therapeutic use Side effects Single photon emission computed tomography Tissue Distribution Translations Tumors Zirconium isotopes
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