A posterior probability based Bayesian method for single-cell RNA-seq data imputation

•We propose BayesImpute, a novel statistical algorithm to impute scRNA-seq data. BayesImpute first identifies likely dropouts, and then only imputes these values, which preserves the true biological signal and reduces the introduction of unwanted bias during imputation.•Unlike other statistical impu...

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Veröffentlicht in:	Methods (San Diego, Calif.) Calif.), 2023-08, Vol.216, p.21-38
Hauptverfasser:	Chen, Siqi, Zheng, Ruiqing, Tian, Luyi, Wu, Fang-Xiang, Li, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayesian model Dropouts Imputation Single-cell RNA-seq
Online-Zugang:	Volltext
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