Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition

This study aimed to assess the efficacy of ethanolic extract of Solanum torvum L. fruit (EESTF) containing solasodine in treating chronic constriction injury (CCI)–induced neuropathic pain in rats. Three-dimensional (3D) simulation studies of solasodine binding were conducted on the TRPV1 receptor,...

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Veröffentlicht in:	Molecular neurobiology 2023-09, Vol.60 (9), p.5378-5394
Hauptverfasser:	Jain, Vivek, Sinha, Saurabh K., Rustage, Kajol, Pareek, Ashutosh, Srivastava, Manish, Meena, Mukesh K., Shakya, Anshul, Gupta, Madan Mohan, Rai, Nitish, Pareek, Aaushi, Ratan, Yashumati, Chen, Min Hua, Prasad, Satyendra Kumar, Ashraf, Ghulam Md
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analgesics Antioxidants Biomedical and Life Sciences Biomedicine Capsaicin Capsaicin receptors Cell Biology Cytokines Experiments Fever Fruits Glutathione Hyperalgesia Inflammation Interleukin 6 Kidney stones Medical research Narcotics Neuralgia Neurobiology Neurology Neurosciences Pain Pain perception Pharmaceutical sciences Pharmacy Sodium Solanum torvum Tumor necrosis factor-α
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