Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition
This study aimed to assess the efficacy of ethanolic extract of Solanum torvum L. fruit (EESTF) containing solasodine in treating chronic constriction injury (CCI)–induced neuropathic pain in rats. Three-dimensional (3D) simulation studies of solasodine binding were conducted on the TRPV1 receptor,...
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| Veröffentlicht in: | Molecular neurobiology 2023-09, Vol.60 (9), p.5378-5394 |
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| creator | Jain, Vivek Sinha, Saurabh K. Rustage, Kajol Pareek, Ashutosh Srivastava, Manish Meena, Mukesh K. Shakya, Anshul Gupta, Madan Mohan Rai, Nitish Pareek, Aaushi Ratan, Yashumati Chen, Min Hua Prasad, Satyendra Kumar Ashraf, Ghulam Md |
| description | This study aimed to assess the efficacy of ethanolic extract of
Solanum torvum
L. fruit (EESTF) containing solasodine in treating chronic constriction injury (CCI)–induced neuropathic pain in rats. Three-dimensional (3D) simulation studies of solasodine binding were conducted on the TRPV1 receptor, IL-6, and TNF-α structures. For in vivo justification, an assessment of behavioral, biochemical, and histological changes was designed after a CCI-induced neuropathic pain model in rats. On days 7, 14, and 21, CCI significantly increased mechanical, thermal, and cold allodynia while producing a functional deficit. IL-6, TNF-α, TBARS, and MPO levels also increased. SOD levels of catalase and reduced glutathione levels also decreased. Administration of pregabalin (30 mg/kg, oral), solasodine (25 mg/kg, oral), and EESTF (100 and 300 mg/kg, oral) significantly reduced CCI-induced behavioral and biochemical changes (
P
< 0.05). The protective nature of EESTF was also confirmed by histological analysis. Capsaicin, a TRPV1 receptor agonist, abolished the antinociceptive effects of EESTF when used previously. From the observations of the docking studies, solasodine acted as an antagonist at TRPV1, whereas the docking scores of solasodine against TNF-α and IL-6 were reported to be −11.2 and −6.04 kcal/mol, respectively. The attenuating effect of EESTF might be related to its antagonistic effects on TRPV1, suppression of cytokines, and anti-inflammatory and antioxidant properties. |
| doi_str_mv | 10.1007/s12035-023-03412-w |
| format | Article |
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Solanum torvum
L. fruit (EESTF) containing solasodine in treating chronic constriction injury (CCI)–induced neuropathic pain in rats. Three-dimensional (3D) simulation studies of solasodine binding were conducted on the TRPV1 receptor, IL-6, and TNF-α structures. For in vivo justification, an assessment of behavioral, biochemical, and histological changes was designed after a CCI-induced neuropathic pain model in rats. On days 7, 14, and 21, CCI significantly increased mechanical, thermal, and cold allodynia while producing a functional deficit. IL-6, TNF-α, TBARS, and MPO levels also increased. SOD levels of catalase and reduced glutathione levels also decreased. Administration of pregabalin (30 mg/kg, oral), solasodine (25 mg/kg, oral), and EESTF (100 and 300 mg/kg, oral) significantly reduced CCI-induced behavioral and biochemical changes (
P
< 0.05). The protective nature of EESTF was also confirmed by histological analysis. Capsaicin, a TRPV1 receptor agonist, abolished the antinociceptive effects of EESTF when used previously. From the observations of the docking studies, solasodine acted as an antagonist at TRPV1, whereas the docking scores of solasodine against TNF-α and IL-6 were reported to be −11.2 and −6.04 kcal/mol, respectively. The attenuating effect of EESTF might be related to its antagonistic effects on TRPV1, suppression of cytokines, and anti-inflammatory and antioxidant properties.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-023-03412-w</identifier><identifier>PMID: 37314657</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acids ; Analgesics ; Antioxidants ; Biomedical and Life Sciences ; Biomedicine ; Capsaicin ; Capsaicin receptors ; Cell Biology ; Cytokines ; Experiments ; Fever ; Fruits ; Glutathione ; Hyperalgesia ; Inflammation ; Interleukin 6 ; Kidney stones ; Medical research ; Narcotics ; Neuralgia ; Neurobiology ; Neurology ; Neurosciences ; Pain ; Pain perception ; Pharmaceutical sciences ; Pharmacy ; Sodium ; Solanum torvum ; Tumor necrosis factor-α</subject><ispartof>Molecular neurobiology, 2023-09, Vol.60 (9), p.5378-5394</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-d35890b4f0c3a409e5a1669e72da71646238d6b9147a3e324b175d693b90e9813</cites><orcidid>0000-0002-4781-4867</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-023-03412-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-023-03412-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37314657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jain, Vivek</creatorcontrib><creatorcontrib>Sinha, Saurabh K.</creatorcontrib><creatorcontrib>Rustage, Kajol</creatorcontrib><creatorcontrib>Pareek, Ashutosh</creatorcontrib><creatorcontrib>Srivastava, Manish</creatorcontrib><creatorcontrib>Meena, Mukesh K.</creatorcontrib><creatorcontrib>Shakya, Anshul</creatorcontrib><creatorcontrib>Gupta, Madan Mohan</creatorcontrib><creatorcontrib>Rai, Nitish</creatorcontrib><creatorcontrib>Pareek, Aaushi</creatorcontrib><creatorcontrib>Ratan, Yashumati</creatorcontrib><creatorcontrib>Chen, Min Hua</creatorcontrib><creatorcontrib>Prasad, Satyendra Kumar</creatorcontrib><creatorcontrib>Ashraf, Ghulam Md</creatorcontrib><title>Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>This study aimed to assess the efficacy of ethanolic extract of
Solanum torvum
L. fruit (EESTF) containing solasodine in treating chronic constriction injury (CCI)–induced neuropathic pain in rats. Three-dimensional (3D) simulation studies of solasodine binding were conducted on the TRPV1 receptor, IL-6, and TNF-α structures. For in vivo justification, an assessment of behavioral, biochemical, and histological changes was designed after a CCI-induced neuropathic pain model in rats. On days 7, 14, and 21, CCI significantly increased mechanical, thermal, and cold allodynia while producing a functional deficit. IL-6, TNF-α, TBARS, and MPO levels also increased. SOD levels of catalase and reduced glutathione levels also decreased. Administration of pregabalin (30 mg/kg, oral), solasodine (25 mg/kg, oral), and EESTF (100 and 300 mg/kg, oral) significantly reduced CCI-induced behavioral and biochemical changes (
P
< 0.05). The protective nature of EESTF was also confirmed by histological analysis. Capsaicin, a TRPV1 receptor agonist, abolished the antinociceptive effects of EESTF when used previously. From the observations of the docking studies, solasodine acted as an antagonist at TRPV1, whereas the docking scores of solasodine against TNF-α and IL-6 were reported to be −11.2 and −6.04 kcal/mol, respectively. The attenuating effect of EESTF might be related to its antagonistic effects on TRPV1, suppression of cytokines, and anti-inflammatory and antioxidant properties.</description><subject>Acids</subject><subject>Analgesics</subject><subject>Antioxidants</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Capsaicin</subject><subject>Capsaicin receptors</subject><subject>Cell Biology</subject><subject>Cytokines</subject><subject>Experiments</subject><subject>Fever</subject><subject>Fruits</subject><subject>Glutathione</subject><subject>Hyperalgesia</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Kidney stones</subject><subject>Medical research</subject><subject>Narcotics</subject><subject>Neuralgia</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacy</subject><subject>Sodium</subject><subject>Solanum torvum</subject><subject>Tumor necrosis factor-α</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc1uEzEUhS0EoqHwAiyQJTZspvhnbI_ZoVEKkSKI0tLtyGM7jUNip7YnJQ_Ie-FpCkgskCxd-fo75175APAaowuMkHifMEGUVYjQCtEak-r-CZhgxmSFcUOegglqJK0Er5sz8CKlDUKEYCSegzMqKK45ExPw8ypsVQrGeQvb4LNy3vlbOHb9sIM5xEMp8wt4GQeX4fRHjkpnuIj2YH1OsF3H4J0etSlHp7MLHs78ZojHaubNoK2BX-wQw17ldeEWZQAsZ6ly-lBAeOW2TgeovBlvN-4Q4PTgjPXawrCC18vFDYZLq-2-7PKAtcccvo_7zvza9W6c-BI8W6ltsq8e6zn4djm9bj9X86-fZu3HeaUp4bkylDUS9fUKaapqJC1TmHNpBTFKYF5zQhvDe4lroailpO6xYIZL2ktkZYPpOXh38t3HcDfYlLudS9puy2fZMKSONIQ1SBI6om__QTdhiL5sV6i64UhwxgpFTpSOIaVoV90-up2Kxw6jbgy5O4XclZC7h5C7-yJ682g99Dtr_kh-p1oAegJSefK3Nv6d_R_bX7JAs6Q</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Jain, Vivek</creator><creator>Sinha, Saurabh K.</creator><creator>Rustage, Kajol</creator><creator>Pareek, Ashutosh</creator><creator>Srivastava, Manish</creator><creator>Meena, Mukesh K.</creator><creator>Shakya, Anshul</creator><creator>Gupta, Madan Mohan</creator><creator>Rai, Nitish</creator><creator>Pareek, Aaushi</creator><creator>Ratan, Yashumati</creator><creator>Chen, Min Hua</creator><creator>Prasad, Satyendra Kumar</creator><creator>Ashraf, Ghulam Md</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4781-4867</orcidid></search><sort><creationdate>20230901</creationdate><title>Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition</title><author>Jain, Vivek ; Sinha, Saurabh K. ; Rustage, Kajol ; Pareek, Ashutosh ; Srivastava, Manish ; Meena, Mukesh K. ; Shakya, Anshul ; Gupta, Madan Mohan ; Rai, Nitish ; Pareek, Aaushi ; Ratan, Yashumati ; Chen, Min Hua ; Prasad, Satyendra Kumar ; Ashraf, Ghulam Md</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-d35890b4f0c3a409e5a1669e72da71646238d6b9147a3e324b175d693b90e9813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acids</topic><topic>Analgesics</topic><topic>Antioxidants</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Capsaicin</topic><topic>Capsaicin receptors</topic><topic>Cell Biology</topic><topic>Cytokines</topic><topic>Experiments</topic><topic>Fever</topic><topic>Fruits</topic><topic>Glutathione</topic><topic>Hyperalgesia</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Kidney stones</topic><topic>Medical research</topic><topic>Narcotics</topic><topic>Neuralgia</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacy</topic><topic>Sodium</topic><topic>Solanum torvum</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jain, Vivek</creatorcontrib><creatorcontrib>Sinha, Saurabh K.</creatorcontrib><creatorcontrib>Rustage, Kajol</creatorcontrib><creatorcontrib>Pareek, Ashutosh</creatorcontrib><creatorcontrib>Srivastava, Manish</creatorcontrib><creatorcontrib>Meena, Mukesh K.</creatorcontrib><creatorcontrib>Shakya, Anshul</creatorcontrib><creatorcontrib>Gupta, Madan Mohan</creatorcontrib><creatorcontrib>Rai, Nitish</creatorcontrib><creatorcontrib>Pareek, Aaushi</creatorcontrib><creatorcontrib>Ratan, Yashumati</creatorcontrib><creatorcontrib>Chen, Min Hua</creatorcontrib><creatorcontrib>Prasad, Satyendra Kumar</creatorcontrib><creatorcontrib>Ashraf, Ghulam Md</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jain, Vivek</au><au>Sinha, Saurabh K.</au><au>Rustage, Kajol</au><au>Pareek, Ashutosh</au><au>Srivastava, Manish</au><au>Meena, Mukesh K.</au><au>Shakya, Anshul</au><au>Gupta, Madan Mohan</au><au>Rai, Nitish</au><au>Pareek, Aaushi</au><au>Ratan, Yashumati</au><au>Chen, Min Hua</au><au>Prasad, Satyendra Kumar</au><au>Ashraf, Ghulam Md</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>60</volume><issue>9</issue><spage>5378</spage><epage>5394</epage><pages>5378-5394</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>This study aimed to assess the efficacy of ethanolic extract of
Solanum torvum
L. fruit (EESTF) containing solasodine in treating chronic constriction injury (CCI)–induced neuropathic pain in rats. Three-dimensional (3D) simulation studies of solasodine binding were conducted on the TRPV1 receptor, IL-6, and TNF-α structures. For in vivo justification, an assessment of behavioral, biochemical, and histological changes was designed after a CCI-induced neuropathic pain model in rats. On days 7, 14, and 21, CCI significantly increased mechanical, thermal, and cold allodynia while producing a functional deficit. IL-6, TNF-α, TBARS, and MPO levels also increased. SOD levels of catalase and reduced glutathione levels also decreased. Administration of pregabalin (30 mg/kg, oral), solasodine (25 mg/kg, oral), and EESTF (100 and 300 mg/kg, oral) significantly reduced CCI-induced behavioral and biochemical changes (
P
< 0.05). The protective nature of EESTF was also confirmed by histological analysis. Capsaicin, a TRPV1 receptor agonist, abolished the antinociceptive effects of EESTF when used previously. From the observations of the docking studies, solasodine acted as an antagonist at TRPV1, whereas the docking scores of solasodine against TNF-α and IL-6 were reported to be −11.2 and −6.04 kcal/mol, respectively. The attenuating effect of EESTF might be related to its antagonistic effects on TRPV1, suppression of cytokines, and anti-inflammatory and antioxidant properties.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37314657</pmid><doi>10.1007/s12035-023-03412-w</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-4781-4867</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Molecular neurobiology, 2023-09, Vol.60 (9), p.5378-5394 |
| issn | 0893-7648 1559-1182 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Acids Analgesics Antioxidants Biomedical and Life Sciences Biomedicine Capsaicin Capsaicin receptors Cell Biology Cytokines Experiments Fever Fruits Glutathione Hyperalgesia Inflammation Interleukin 6 Kidney stones Medical research Narcotics Neuralgia Neurobiology Neurology Neurosciences Pain Pain perception Pharmaceutical sciences Pharmacy Sodium Solanum torvum Tumor necrosis factor-α |
| title | Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition |
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