Interleukin-22 Inhibits Apoptosis of Gingival Epithelial Cells Through TGF-β Signaling Pathway During Periodontitis

Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues. The gingival epithelium is the first barrier of periodontal tissue against oral pathogens and harmful substances. The structure and function of epithelial lining are essential for maintainin...

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Veröffentlicht in:	Inflammation 2023-10, Vol.46 (5), p.1871-1886
Hauptverfasser:	Huang, Yina, Zhang, Lu, Tan, Lingping, Zhang, Chi, Li, Xiting, Wang, Panpan, Gao, Li, Zhao, Chuanjiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bcl-x protein Biomedical and Life Sciences Biomedicine Cytokines Epithelial cells Epithelial Cells - metabolism Epithelium Gingiva Gingiva - metabolism Gum disease Homeostasis Humans Immunology Inflammatory diseases Interleukin 22 Internal Medicine Keratinocytes Mice Pathology Periodontitis Periodontitis - metabolism Pharmacology/Toxicology Phosphorylation Porphyromonas gingivalis Porphyromonas gingivalis - metabolism Rheumatology Signal Transduction Smad2 protein Structure-function relationships Transforming Growth Factor beta - metabolism Transforming growth factor-b
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