Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury

Background This study aims to investigate the correlation between Erbin and sepsis, and the role of Erbin on the pyroptosis pathway in acute kidney injury caused by sepsis and NLRP3/caspase-1/Gasdermin D pathway. Methods In the study, lipopolysaccharide (LPS) treatment or cecal ligation and puncture...

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Veröffentlicht in:	Clinical and experimental nephrology 2023-09, Vol.27 (9), p.781-790
Hauptverfasser:	Liu, Yuping, Fang, Qing, Ming, Tingqian, Zuo, Jing, Jing, Guoqing, Song, Xuemin
Format:	Artikel
Sprache:	eng
Schlagworte:	Caspase-1 Cecum Gene expression Inflammasomes Inflammation Kidneys Lipopolysaccharides Medicine Medicine & Public Health Nephrology Original Article Pyroptosis Renal function Sepsis Urology
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