Synthesis, biological screening and in silico studies of new N-phenyl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine derivatives as potential antifungal and antitubercular agents

A new series of N-aryl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine, (8a-x) have been synthesized by a cyclo-condensation reaction of 2-bromo-1-(1,3-diphenyl-1H-pyrazol-4-yl)ethanone (6a-f) with N-aryl thiourea, (7a-d). The structure of newly synthesized N-aryl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol...

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Veröffentlicht in:	European journal of medicinal chemistry 2023-10, Vol.258, p.115548-115548, Article 115548
Hauptverfasser:	Nandurkar, Yogesh, Bhoye, Manish R., Maliwal, Deepika, Pissurlenkar, Raghuvir R.S., Chavan, Abhijit, Katade, Sushma, Mhaske, Pravin C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial activity Antitubercular activity Molecular docking Molecular dynamics simulations Pyrazole Thiazole
Online-Zugang:	Volltext
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