Bronchial thermoplasty improves cough hypersensitivity and cough in severe asthmatics
Cough is a troublesome symptom of asthma because it is associated with disease severity and poor asthma control. Bronchial thermoplasty (BT) may be effective in improving cough severity and cough-related quality of life in severe uncontrolled asthma. To evaluate the efficacy of BT for cough in sever...
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| Veröffentlicht in: | Respiratory medicine 2023-09, Vol.216, p.107303-107303, Article 107303 |
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| creator | Nishiyama, Hirono Kanemitsu, Yoshihiro Hara, Johsuke Fukumitsu, Kensuke Takeda, Norihisa Kurokawa, Ryota Ito, Keima Tajiri, Tomoko Fukuda, Satoshi Uemura, Takehiro Ohkubo, Hirotsugu Maeno, Ken Ito, Yutaka Oguri, Tetsuya Takemura, Masaya Niimi, Akio |
| description | Cough is a troublesome symptom of asthma because it is associated with disease severity and poor asthma control. Bronchial thermoplasty (BT) may be effective in improving cough severity and cough-related quality of life in severe uncontrolled asthma.
To evaluate the efficacy of BT for cough in severe uncontrolled asthma.
Twelve patients with severe uncontrolled asthma were enrolled in this study between 2018 May and March 2021 and arbitrarily divided into cough-predominant [cough severity Visual Analog Scale (VAS) ≥ 40 mm, n = 8] and typical asthma (cough VAS |
| doi_str_mv | 10.1016/j.rmed.2023.107303 |
| format | Article |
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To evaluate the efficacy of BT for cough in severe uncontrolled asthma.
Twelve patients with severe uncontrolled asthma were enrolled in this study between 2018 May and March 2021 and arbitrarily divided into cough-predominant [cough severity Visual Analog Scale (VAS) ≥ 40 mm, n = 8] and typical asthma (cough VAS <40 mm, n = 4) groups. Clinical parameters, such as capsaicin cough sensitivity [C-CS: the concentrations to inhaled capsaicin required to induce at least two (C2) and five (C5) coughs], lung function, and type-2–related biomarkers (fractional nitric oxides and absolute eosinophil counts) and cough-related indices [cough severity VAS and the Leicester Cough Questionnaire (LCQ)] were evaluated before and 3 months after performing BT.
BT significantly improved both cough-related indices and C-CS in the cough-predominant group. Changes in C-CS were significantly correlated with changes in the LCQ scores (C5: r = 0.65, p = 0.02 for all patients, and r = 0.81, p = 0.01 for the cough-predominant group).
BT may be effective for cough in severe uncontrolled asthma by improving C-CS. However, further larger cohort studies are necessary to confirm the effect of BT for cough in asthma.
This study was registered in the UMIN Clinical Trials Registry (Registry ID UMIN: 000031982).
•Cough is an important symptom in the management of severe asthma.•Cough reflex hypersensitivity, airway hyperresponsiveness (AHR) and airway inflammation are associated with cough in asthma.•Bronchial thermoplasty improved cough in patients with severe asthma by improving capsaicin cough sensitivity (C-CS).•Heightened C-CS may be a therapeutic target for cough in severe asthma, along with AHR and airway inflammation.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2023.107303</identifier><identifier>PMID: 37307903</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Asthma ; Asthma - drug therapy ; Bronchial Thermoplasty ; Capsaicin ; Capsaicin cough sensitivity ; Cough ; Cough - etiology ; Cough - surgery ; Humans ; Quality of Life</subject><ispartof>Respiratory medicine, 2023-09, Vol.216, p.107303-107303, Article 107303</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c373t-8a681aa66040cebbf43856c8a1b65a78c8b42d88c907c9d5fdc99c6ff53789003</cites><orcidid>0000-0003-0115-2615 ; 0000-0002-1529-9477</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2023.107303$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37307903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishiyama, Hirono</creatorcontrib><creatorcontrib>Kanemitsu, Yoshihiro</creatorcontrib><creatorcontrib>Hara, Johsuke</creatorcontrib><creatorcontrib>Fukumitsu, Kensuke</creatorcontrib><creatorcontrib>Takeda, Norihisa</creatorcontrib><creatorcontrib>Kurokawa, Ryota</creatorcontrib><creatorcontrib>Ito, Keima</creatorcontrib><creatorcontrib>Tajiri, Tomoko</creatorcontrib><creatorcontrib>Fukuda, Satoshi</creatorcontrib><creatorcontrib>Uemura, Takehiro</creatorcontrib><creatorcontrib>Ohkubo, Hirotsugu</creatorcontrib><creatorcontrib>Maeno, Ken</creatorcontrib><creatorcontrib>Ito, Yutaka</creatorcontrib><creatorcontrib>Oguri, Tetsuya</creatorcontrib><creatorcontrib>Takemura, Masaya</creatorcontrib><creatorcontrib>Niimi, Akio</creatorcontrib><title>Bronchial thermoplasty improves cough hypersensitivity and cough in severe asthmatics</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Cough is a troublesome symptom of asthma because it is associated with disease severity and poor asthma control. Bronchial thermoplasty (BT) may be effective in improving cough severity and cough-related quality of life in severe uncontrolled asthma.
To evaluate the efficacy of BT for cough in severe uncontrolled asthma.
Twelve patients with severe uncontrolled asthma were enrolled in this study between 2018 May and March 2021 and arbitrarily divided into cough-predominant [cough severity Visual Analog Scale (VAS) ≥ 40 mm, n = 8] and typical asthma (cough VAS <40 mm, n = 4) groups. Clinical parameters, such as capsaicin cough sensitivity [C-CS: the concentrations to inhaled capsaicin required to induce at least two (C2) and five (C5) coughs], lung function, and type-2–related biomarkers (fractional nitric oxides and absolute eosinophil counts) and cough-related indices [cough severity VAS and the Leicester Cough Questionnaire (LCQ)] were evaluated before and 3 months after performing BT.
BT significantly improved both cough-related indices and C-CS in the cough-predominant group. Changes in C-CS were significantly correlated with changes in the LCQ scores (C5: r = 0.65, p = 0.02 for all patients, and r = 0.81, p = 0.01 for the cough-predominant group).
BT may be effective for cough in severe uncontrolled asthma by improving C-CS. However, further larger cohort studies are necessary to confirm the effect of BT for cough in asthma.
This study was registered in the UMIN Clinical Trials Registry (Registry ID UMIN: 000031982).
•Cough is an important symptom in the management of severe asthma.•Cough reflex hypersensitivity, airway hyperresponsiveness (AHR) and airway inflammation are associated with cough in asthma.•Bronchial thermoplasty improved cough in patients with severe asthma by improving capsaicin cough sensitivity (C-CS).•Heightened C-CS may be a therapeutic target for cough in severe asthma, along with AHR and airway inflammation.</description><subject>Asthma</subject><subject>Asthma - drug therapy</subject><subject>Bronchial Thermoplasty</subject><subject>Capsaicin</subject><subject>Capsaicin cough sensitivity</subject><subject>Cough</subject><subject>Cough - etiology</subject><subject>Cough - surgery</subject><subject>Humans</subject><subject>Quality of Life</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAQxy0EoqXwBRhQRpaUc5w4jsQCFS-pEgudLce5EFd5FDuJ1G-Po5SV6aT7P3T3I-SWwpoC5Q_7tW2wWEcQMb9IGbAzsqQJi0IGPD4nS8iSOOSU0gW5cm4PAFkcwyVZMG9OM2BLsnu2Xasro-qgr9A23aFWrj8GpjnYbkQX6G74roLqeEDrsHWmN6PxumqLk2TawOGIFgMfrBrVG-2uyUWpaoc3p7kiu9eXr817uP18-9g8bUPtL-hDobigSnEOMWjM8zJmIuFaKJrzRKVCizyOCiF0BqnOiqQsdJZpXpYJS0UGwFbkfu71x_4M6HrZGKexrlWL3eBkJKIkARAs8tZotmrbOWexlAdrGmWPkoKccMq9nHDKCaeccfrQ3al_yCftL_LHzxseZwP6L0eDVjptsNVYGIu6l0Vn_uv_BWQih5g</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Nishiyama, Hirono</creator><creator>Kanemitsu, Yoshihiro</creator><creator>Hara, Johsuke</creator><creator>Fukumitsu, Kensuke</creator><creator>Takeda, Norihisa</creator><creator>Kurokawa, Ryota</creator><creator>Ito, Keima</creator><creator>Tajiri, Tomoko</creator><creator>Fukuda, Satoshi</creator><creator>Uemura, Takehiro</creator><creator>Ohkubo, Hirotsugu</creator><creator>Maeno, Ken</creator><creator>Ito, Yutaka</creator><creator>Oguri, Tetsuya</creator><creator>Takemura, Masaya</creator><creator>Niimi, Akio</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0115-2615</orcidid><orcidid>https://orcid.org/0000-0002-1529-9477</orcidid></search><sort><creationdate>202309</creationdate><title>Bronchial thermoplasty improves cough hypersensitivity and cough in severe asthmatics</title><author>Nishiyama, Hirono ; Kanemitsu, Yoshihiro ; Hara, Johsuke ; Fukumitsu, Kensuke ; Takeda, Norihisa ; Kurokawa, Ryota ; Ito, Keima ; Tajiri, Tomoko ; Fukuda, Satoshi ; Uemura, Takehiro ; Ohkubo, Hirotsugu ; Maeno, Ken ; Ito, Yutaka ; Oguri, Tetsuya ; Takemura, Masaya ; Niimi, Akio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-8a681aa66040cebbf43856c8a1b65a78c8b42d88c907c9d5fdc99c6ff53789003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Asthma</topic><topic>Asthma - drug therapy</topic><topic>Bronchial Thermoplasty</topic><topic>Capsaicin</topic><topic>Capsaicin cough sensitivity</topic><topic>Cough</topic><topic>Cough - etiology</topic><topic>Cough - surgery</topic><topic>Humans</topic><topic>Quality of Life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishiyama, Hirono</creatorcontrib><creatorcontrib>Kanemitsu, Yoshihiro</creatorcontrib><creatorcontrib>Hara, Johsuke</creatorcontrib><creatorcontrib>Fukumitsu, Kensuke</creatorcontrib><creatorcontrib>Takeda, Norihisa</creatorcontrib><creatorcontrib>Kurokawa, Ryota</creatorcontrib><creatorcontrib>Ito, Keima</creatorcontrib><creatorcontrib>Tajiri, Tomoko</creatorcontrib><creatorcontrib>Fukuda, Satoshi</creatorcontrib><creatorcontrib>Uemura, Takehiro</creatorcontrib><creatorcontrib>Ohkubo, Hirotsugu</creatorcontrib><creatorcontrib>Maeno, Ken</creatorcontrib><creatorcontrib>Ito, Yutaka</creatorcontrib><creatorcontrib>Oguri, Tetsuya</creatorcontrib><creatorcontrib>Takemura, Masaya</creatorcontrib><creatorcontrib>Niimi, Akio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishiyama, Hirono</au><au>Kanemitsu, Yoshihiro</au><au>Hara, Johsuke</au><au>Fukumitsu, Kensuke</au><au>Takeda, Norihisa</au><au>Kurokawa, Ryota</au><au>Ito, Keima</au><au>Tajiri, Tomoko</au><au>Fukuda, Satoshi</au><au>Uemura, Takehiro</au><au>Ohkubo, Hirotsugu</au><au>Maeno, Ken</au><au>Ito, Yutaka</au><au>Oguri, Tetsuya</au><au>Takemura, Masaya</au><au>Niimi, Akio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchial thermoplasty improves cough hypersensitivity and cough in severe asthmatics</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2023-09</date><risdate>2023</risdate><volume>216</volume><spage>107303</spage><epage>107303</epage><pages>107303-107303</pages><artnum>107303</artnum><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Cough is a troublesome symptom of asthma because it is associated with disease severity and poor asthma control. Bronchial thermoplasty (BT) may be effective in improving cough severity and cough-related quality of life in severe uncontrolled asthma.
To evaluate the efficacy of BT for cough in severe uncontrolled asthma.
Twelve patients with severe uncontrolled asthma were enrolled in this study between 2018 May and March 2021 and arbitrarily divided into cough-predominant [cough severity Visual Analog Scale (VAS) ≥ 40 mm, n = 8] and typical asthma (cough VAS <40 mm, n = 4) groups. Clinical parameters, such as capsaicin cough sensitivity [C-CS: the concentrations to inhaled capsaicin required to induce at least two (C2) and five (C5) coughs], lung function, and type-2–related biomarkers (fractional nitric oxides and absolute eosinophil counts) and cough-related indices [cough severity VAS and the Leicester Cough Questionnaire (LCQ)] were evaluated before and 3 months after performing BT.
BT significantly improved both cough-related indices and C-CS in the cough-predominant group. Changes in C-CS were significantly correlated with changes in the LCQ scores (C5: r = 0.65, p = 0.02 for all patients, and r = 0.81, p = 0.01 for the cough-predominant group).
BT may be effective for cough in severe uncontrolled asthma by improving C-CS. However, further larger cohort studies are necessary to confirm the effect of BT for cough in asthma.
This study was registered in the UMIN Clinical Trials Registry (Registry ID UMIN: 000031982).
•Cough is an important symptom in the management of severe asthma.•Cough reflex hypersensitivity, airway hyperresponsiveness (AHR) and airway inflammation are associated with cough in asthma.•Bronchial thermoplasty improved cough in patients with severe asthma by improving capsaicin cough sensitivity (C-CS).•Heightened C-CS may be a therapeutic target for cough in severe asthma, along with AHR and airway inflammation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37307903</pmid><doi>10.1016/j.rmed.2023.107303</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0115-2615</orcidid><orcidid>https://orcid.org/0000-0002-1529-9477</orcidid></addata></record> |
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| subjects | Asthma Asthma - drug therapy Bronchial Thermoplasty Capsaicin Capsaicin cough sensitivity Cough Cough - etiology Cough - surgery Humans Quality of Life |
| title | Bronchial thermoplasty improves cough hypersensitivity and cough in severe asthmatics |
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