Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage

Background Brain perivascular macrophages (PVMs) are potential treatment targets for subarachnoid hemorrhage (SAH), and previous studies revealed that their depletion by clodronate (CLD) improved outcomes after experimental SAH. However, the underlying mechanisms are not well understood. Therefore,...

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Veröffentlicht in:	Neurocritical care 2023-08, Vol.39 (1), p.207-217
Hauptverfasser:	Uchikawa, Hiroki, Kameno, Koki, Kai, Keitaro, Kajiwara, Sosho, Fujimori, Kana, Uekawa, Ken, Fujiwara, Yukio, Mukasa, Akitake, Kim-Mitsuyama, Shokei, Hasegawa, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood pressure Critical Care Medicine Cytotoxicity Experiments Hemorrhage Intensive Internal Medicine Medicine Medicine & Public Health Neurology Neurosurgery Original Work Polymerase chain reaction Traumatic brain injury
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