Association between sarcopenia and exercise capacity in patients with pulmonary hypertension without left heart disease
Pulmonary hypertension (PH) has recently been described as a complex clinical syndrome affecting multiple organ systems, including the heart, lungs, and skeletal muscle, each of which plays an important role in exercise capacity. However, the relationship between exercise capacity and skeletal muscl...
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| Veröffentlicht in: | International journal of cardiology 2023-09, Vol.387, p.131115, Article 131115 |
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| creator | Nakayama, Mina Konishi, Masaaki Sugano, Teruyasu Okamura, Masatsugu Gohbara, Masaomi Iwata, Kiwamu Nakayama, Naoki Akiyama, Eiichi Komura, Naohiro Nitta, Manabu Kawaura, Noriyuki Ishigami, Tomoaki Hibi, Kiyoshi Ishikawa, Toshiyuki Nakamura, Takeshi Tamura, Kouichi Kimura, Kazuo |
| description | Pulmonary hypertension (PH) has recently been described as a complex clinical syndrome affecting multiple organ systems, including the heart, lungs, and skeletal muscle, each of which plays an important role in exercise capacity. However, the relationship between exercise capacity and skeletal muscle abnormalities in patients with PH has not been fully elucidated.
We retrospectively analysed the exercise capacity and measures of skeletal muscle of 107 patients with PH without left heart disease (mean age 63 ± 15 years, 32.7% males, n = 30/6/66/5 in the clinical classification Group 1/3/4/5).
Sarcopenia, low appendicular skeletal muscle mass index, low grip strength, and slow gait speed, determined by international criteria, were found in 15 (14.0%), 16 (15.0%), 62 (57.9%), and 41 (38.3%) patients, respectively. The mean 6-min walk distance of all patients was 436 ± 134 m and was independently associated with sarcopenia (standardised β = −0.292, p |
| doi_str_mv | 10.1016/j.ijcard.2023.06.006 |
| format | Article |
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We retrospectively analysed the exercise capacity and measures of skeletal muscle of 107 patients with PH without left heart disease (mean age 63 ± 15 years, 32.7% males, n = 30/6/66/5 in the clinical classification Group 1/3/4/5).
Sarcopenia, low appendicular skeletal muscle mass index, low grip strength, and slow gait speed, determined by international criteria, were found in 15 (14.0%), 16 (15.0%), 62 (57.9%), and 41 (38.3%) patients, respectively. The mean 6-min walk distance of all patients was 436 ± 134 m and was independently associated with sarcopenia (standardised β = −0.292, p < 0.001). All patients with sarcopenia showed reduced exercise capacity defined as 6-min walk distance < 440 m. Multivariable logistic regression analysis showed that each of the components of sarcopenia was associated with reduced exercise capacity (adjusted odds ratio and 95% confidence interval of appendicular skeletal muscle mass index: 0.39 [0.24–0.63] per 1 kg/m2, p = 0.006, grip strength: 0.83 [0.74–0.94] per 1 kg, p = 0.003, and gait speed: 0.31 [0.18–0.51] per 0.1 m/s, p < 0.001).
Sarcopenia and its components are associated with reduced exercise capacity in patients with PH. A multifaceted evaluation may be important in the management of reduced exercise capacity in patients with PH.
•The influence of skeletal muscle function on exercise tolerance in PH is unclear.•Patients with PH are likely to have disease-related sarcopenia.•Sarcopenia and its components are associated with 6MWD.</description><identifier>ISSN: 0167-5273</identifier><identifier>ISSN: 1874-1754</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2023.06.006</identifier><identifier>PMID: 37302419</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Exercise capacity ; Pulmonary hypertension ; Sarcopenia ; Skeletal muscle</subject><ispartof>International journal of cardiology, 2023-09, Vol.387, p.131115, Article 131115</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-9efb8893df0a59ab42d0db8a1bb67aff58ea658a78ae894faa3d06d4a1dffd6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167527323008835$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37302419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakayama, Mina</creatorcontrib><creatorcontrib>Konishi, Masaaki</creatorcontrib><creatorcontrib>Sugano, Teruyasu</creatorcontrib><creatorcontrib>Okamura, Masatsugu</creatorcontrib><creatorcontrib>Gohbara, Masaomi</creatorcontrib><creatorcontrib>Iwata, Kiwamu</creatorcontrib><creatorcontrib>Nakayama, Naoki</creatorcontrib><creatorcontrib>Akiyama, Eiichi</creatorcontrib><creatorcontrib>Komura, Naohiro</creatorcontrib><creatorcontrib>Nitta, Manabu</creatorcontrib><creatorcontrib>Kawaura, Noriyuki</creatorcontrib><creatorcontrib>Ishigami, Tomoaki</creatorcontrib><creatorcontrib>Hibi, Kiyoshi</creatorcontrib><creatorcontrib>Ishikawa, Toshiyuki</creatorcontrib><creatorcontrib>Nakamura, Takeshi</creatorcontrib><creatorcontrib>Tamura, Kouichi</creatorcontrib><creatorcontrib>Kimura, Kazuo</creatorcontrib><title>Association between sarcopenia and exercise capacity in patients with pulmonary hypertension without left heart disease</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Pulmonary hypertension (PH) has recently been described as a complex clinical syndrome affecting multiple organ systems, including the heart, lungs, and skeletal muscle, each of which plays an important role in exercise capacity. However, the relationship between exercise capacity and skeletal muscle abnormalities in patients with PH has not been fully elucidated.
We retrospectively analysed the exercise capacity and measures of skeletal muscle of 107 patients with PH without left heart disease (mean age 63 ± 15 years, 32.7% males, n = 30/6/66/5 in the clinical classification Group 1/3/4/5).
Sarcopenia, low appendicular skeletal muscle mass index, low grip strength, and slow gait speed, determined by international criteria, were found in 15 (14.0%), 16 (15.0%), 62 (57.9%), and 41 (38.3%) patients, respectively. The mean 6-min walk distance of all patients was 436 ± 134 m and was independently associated with sarcopenia (standardised β = −0.292, p < 0.001). All patients with sarcopenia showed reduced exercise capacity defined as 6-min walk distance < 440 m. Multivariable logistic regression analysis showed that each of the components of sarcopenia was associated with reduced exercise capacity (adjusted odds ratio and 95% confidence interval of appendicular skeletal muscle mass index: 0.39 [0.24–0.63] per 1 kg/m2, p = 0.006, grip strength: 0.83 [0.74–0.94] per 1 kg, p = 0.003, and gait speed: 0.31 [0.18–0.51] per 0.1 m/s, p < 0.001).
Sarcopenia and its components are associated with reduced exercise capacity in patients with PH. A multifaceted evaluation may be important in the management of reduced exercise capacity in patients with PH.
•The influence of skeletal muscle function on exercise tolerance in PH is unclear.•Patients with PH are likely to have disease-related sarcopenia.•Sarcopenia and its components are associated with 6MWD.</description><subject>Exercise capacity</subject><subject>Pulmonary hypertension</subject><subject>Sarcopenia</subject><subject>Skeletal muscle</subject><issn>0167-5273</issn><issn>1874-1754</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kMFu1DAQhi0EokvhDarKRy4JduIkzqVSVRWKVIkLPVsTe6z1KmuntsOyb1-vtvTIaQ7z_f9oPkKuOKs54_23Xe12GqKpG9a0Netrxvp3ZMPlICo-dOI92RRsqLpmaC_Ip5R2jDExjvIjuWiHljWCjxtyuE0paAfZBU8nzAdETxNEHRb0Dih4Q_EvRu0SUg0LaJeP1Hm6lAj6nOjB5S1d1nkfPMQj3R4XjBl9OhWedmHNdEab6RYhZmpKEST8TD5YmBN-eZ2X5On7_e-7h-rx14-fd7ePlW45z9WIdpJybI1l0I0wicYwM0ng09QPYG0nEfpOwiAB5SgsQGtYbwRwY63pob0kX8-9SwzPK6as9i5pnGfwGNakGtl0vBu5kAUVZ1THkFJEq5bo9uUnxZk6KVc7dVauTsoV61VRXmLXrxfWaY_mLfTPcQFuzgCWP_84jCrpok6jcRF1Via4_194Ad2qmMY</recordid><startdate>20230915</startdate><enddate>20230915</enddate><creator>Nakayama, Mina</creator><creator>Konishi, Masaaki</creator><creator>Sugano, Teruyasu</creator><creator>Okamura, Masatsugu</creator><creator>Gohbara, Masaomi</creator><creator>Iwata, Kiwamu</creator><creator>Nakayama, Naoki</creator><creator>Akiyama, Eiichi</creator><creator>Komura, Naohiro</creator><creator>Nitta, Manabu</creator><creator>Kawaura, Noriyuki</creator><creator>Ishigami, Tomoaki</creator><creator>Hibi, Kiyoshi</creator><creator>Ishikawa, Toshiyuki</creator><creator>Nakamura, Takeshi</creator><creator>Tamura, Kouichi</creator><creator>Kimura, Kazuo</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230915</creationdate><title>Association between sarcopenia and exercise capacity in patients with pulmonary hypertension without left heart disease</title><author>Nakayama, Mina ; Konishi, Masaaki ; Sugano, Teruyasu ; Okamura, Masatsugu ; Gohbara, Masaomi ; Iwata, Kiwamu ; Nakayama, Naoki ; Akiyama, Eiichi ; Komura, Naohiro ; Nitta, Manabu ; Kawaura, Noriyuki ; Ishigami, Tomoaki ; Hibi, Kiyoshi ; Ishikawa, Toshiyuki ; Nakamura, Takeshi ; Tamura, Kouichi ; Kimura, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-9efb8893df0a59ab42d0db8a1bb67aff58ea658a78ae894faa3d06d4a1dffd6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Exercise capacity</topic><topic>Pulmonary hypertension</topic><topic>Sarcopenia</topic><topic>Skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakayama, Mina</creatorcontrib><creatorcontrib>Konishi, Masaaki</creatorcontrib><creatorcontrib>Sugano, Teruyasu</creatorcontrib><creatorcontrib>Okamura, Masatsugu</creatorcontrib><creatorcontrib>Gohbara, Masaomi</creatorcontrib><creatorcontrib>Iwata, Kiwamu</creatorcontrib><creatorcontrib>Nakayama, Naoki</creatorcontrib><creatorcontrib>Akiyama, Eiichi</creatorcontrib><creatorcontrib>Komura, Naohiro</creatorcontrib><creatorcontrib>Nitta, Manabu</creatorcontrib><creatorcontrib>Kawaura, Noriyuki</creatorcontrib><creatorcontrib>Ishigami, Tomoaki</creatorcontrib><creatorcontrib>Hibi, Kiyoshi</creatorcontrib><creatorcontrib>Ishikawa, Toshiyuki</creatorcontrib><creatorcontrib>Nakamura, Takeshi</creatorcontrib><creatorcontrib>Tamura, Kouichi</creatorcontrib><creatorcontrib>Kimura, Kazuo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakayama, Mina</au><au>Konishi, Masaaki</au><au>Sugano, Teruyasu</au><au>Okamura, Masatsugu</au><au>Gohbara, Masaomi</au><au>Iwata, Kiwamu</au><au>Nakayama, Naoki</au><au>Akiyama, Eiichi</au><au>Komura, Naohiro</au><au>Nitta, Manabu</au><au>Kawaura, Noriyuki</au><au>Ishigami, Tomoaki</au><au>Hibi, Kiyoshi</au><au>Ishikawa, Toshiyuki</au><au>Nakamura, Takeshi</au><au>Tamura, Kouichi</au><au>Kimura, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between sarcopenia and exercise capacity in patients with pulmonary hypertension without left heart disease</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2023-09-15</date><risdate>2023</risdate><volume>387</volume><spage>131115</spage><pages>131115-</pages><artnum>131115</artnum><issn>0167-5273</issn><issn>1874-1754</issn><eissn>1874-1754</eissn><abstract>Pulmonary hypertension (PH) has recently been described as a complex clinical syndrome affecting multiple organ systems, including the heart, lungs, and skeletal muscle, each of which plays an important role in exercise capacity. However, the relationship between exercise capacity and skeletal muscle abnormalities in patients with PH has not been fully elucidated.
We retrospectively analysed the exercise capacity and measures of skeletal muscle of 107 patients with PH without left heart disease (mean age 63 ± 15 years, 32.7% males, n = 30/6/66/5 in the clinical classification Group 1/3/4/5).
Sarcopenia, low appendicular skeletal muscle mass index, low grip strength, and slow gait speed, determined by international criteria, were found in 15 (14.0%), 16 (15.0%), 62 (57.9%), and 41 (38.3%) patients, respectively. The mean 6-min walk distance of all patients was 436 ± 134 m and was independently associated with sarcopenia (standardised β = −0.292, p < 0.001). All patients with sarcopenia showed reduced exercise capacity defined as 6-min walk distance < 440 m. Multivariable logistic regression analysis showed that each of the components of sarcopenia was associated with reduced exercise capacity (adjusted odds ratio and 95% confidence interval of appendicular skeletal muscle mass index: 0.39 [0.24–0.63] per 1 kg/m2, p = 0.006, grip strength: 0.83 [0.74–0.94] per 1 kg, p = 0.003, and gait speed: 0.31 [0.18–0.51] per 0.1 m/s, p < 0.001).
Sarcopenia and its components are associated with reduced exercise capacity in patients with PH. A multifaceted evaluation may be important in the management of reduced exercise capacity in patients with PH.
•The influence of skeletal muscle function on exercise tolerance in PH is unclear.•Patients with PH are likely to have disease-related sarcopenia.•Sarcopenia and its components are associated with 6MWD.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37302419</pmid><doi>10.1016/j.ijcard.2023.06.006</doi></addata></record> |
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| subjects | Exercise capacity Pulmonary hypertension Sarcopenia Skeletal muscle |
| title | Association between sarcopenia and exercise capacity in patients with pulmonary hypertension without left heart disease |
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