Design of novel water-soluble isoxazole-based antimicrobial agents and evaluation of their cytotoxicity and acute toxicity

[Display omitted] •Design and synthesis of novel water-soluble isoxazole-bearing antimicrobial agents.•Screening of substituents at positions 3 and 5 of the isoxazole ring.•Isoxazolyl amino acids show promising bacteriostatic activity (best MIC 0.06–2.5 µg/mL).•((3-Arylisoxazol-5-yl)methyl)-l-prolin...

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