Polymeric micelles amplify tumor oxidative stresses through combining PDT and glutathione depletion for synergistic cancer chemotherapy

•A star-shape polymer based on the Passerini three-component reaction was synthesized.•The ‘‘ROS threshold concept’’ was proposed by combining PDT with GSH depletion.•Triple combination of ROS generation, GSH elimination and chemotherapy was designed. Cancer has been one of the major healthcare burd...

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Veröffentlicht in:	Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2021-05, Vol.411, p.128561, Article 128561
Hauptverfasser:	Su, Ting, Cheng, Furong, Pu, Yuji, Cao, Jun, Lin, Shuibin, Zhu, Guizhi, He, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Arylboronic esters Combination cancer therapy GSH depletion Photodynamic therapy Polymeric micelle
Online-Zugang:	Volltext
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