Discovery of SDS-347 as a specific peptide competitive inhibitor of G9a with promising anti-cancer potential

G9a is a histone H3K9 methyltransferase enzyme found highly upregulated in many cancers. H3 binds to the rigid I-SET domain and the cofactor, S-adenosyl methionine, binds to the flexible post-SET domain of G9a. Inhibition of G9a is known to inhibit the growth of cancer cell-lines. Recombinant G9a an...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects 2023-09, Vol.1867 (9), p.130399-130399, Article 130399
Hauptverfasser:	Jan, Suraya, Dar, Mohd I., Shankar, Gauri, Wani, Rubiada, Sandey, Jagjeet, Balgotra, Shilpi, Mudassir, Syed, Dar, Mohd J., Sawant, Sanghapal D., Akhter, Yusuf, Syed, Sajad H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Line G9a Histone methyltransferase Histone Methyltransferases Histone-Lysine N-Methyltransferase - metabolism Humans K562 Neoplasms Nucleosome Peptides
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