Red cell distribution width-to-albumin ratio is a predictor of survival in hepatitis B virus–associated decompensated cirrhosis
Abstract Objective The aim of this study was to ascertain whether red cell distribution width-to-albumin ratio (RAR) is associated with survival in hepatitis B virus (HBV)–associated decompensated cirrhosis (DC) patients. Methods A cohort of 167 patients with confirmed HBV-DC was enrolled in our stu...
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| Veröffentlicht in: | Laboratory medicine 2024-03, Vol.55 (2), p.127-131 |
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| container_title | Laboratory medicine |
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| creator | Mao, WeiLin Yuan, ManChun He, Xia Zhang, Qiu |
| description | Abstract
Objective
The aim of this study was to ascertain whether red cell distribution width-to-albumin ratio (RAR) is associated with survival in hepatitis B virus (HBV)–associated decompensated cirrhosis (DC) patients.
Methods
A cohort of 167 patients with confirmed HBV-DC was enrolled in our study. Demographic characteristics and laboratory data were obtained. The main endpoint was mortality at 30 days. The receiver operating characteristic curve and multivariable regression analysis were used to assess the power of RAR for predicting prognosis.
Results
Mortality at 30 days was 11.4% (19/167). The RAR levels were higher in the nonsurvivors than the survivors, and elevated RAR levels were clearly associated with poor prognosis. Moreover, the predictive powers of RAR and Model for End-Stage Liver Disease score were not obviously different.
Conclusion
Our data indicate that RAR is a novel potential prognostic biomarker of mortality in HBV-DC. |
| doi_str_mv | 10.1093/labmed/lmad048 |
| format | Article |
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Objective
The aim of this study was to ascertain whether red cell distribution width-to-albumin ratio (RAR) is associated with survival in hepatitis B virus (HBV)–associated decompensated cirrhosis (DC) patients.
Methods
A cohort of 167 patients with confirmed HBV-DC was enrolled in our study. Demographic characteristics and laboratory data were obtained. The main endpoint was mortality at 30 days. The receiver operating characteristic curve and multivariable regression analysis were used to assess the power of RAR for predicting prognosis.
Results
Mortality at 30 days was 11.4% (19/167). The RAR levels were higher in the nonsurvivors than the survivors, and elevated RAR levels were clearly associated with poor prognosis. Moreover, the predictive powers of RAR and Model for End-Stage Liver Disease score were not obviously different.
Conclusion
Our data indicate that RAR is a novel potential prognostic biomarker of mortality in HBV-DC.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1093/labmed/lmad048</identifier><identifier>PMID: 37289932</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Albumins ; Biomarkers ; End Stage Liver Disease - complications ; Erythrocyte Indices ; Hepatitis B virus ; Hepatitis B, Chronic - complications ; Humans ; Liver Cirrhosis - complications ; Liver Cirrhosis - diagnosis ; Prognosis ; Retrospective Studies ; Severity of Illness Index</subject><ispartof>Laboratory medicine, 2024-03, Vol.55 (2), p.127-131</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-4686d2fae4c23bebb3cdf127571aeb61ff18e1d824b7d4a7756e5af17bc1881b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37289932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mao, WeiLin</creatorcontrib><creatorcontrib>Yuan, ManChun</creatorcontrib><creatorcontrib>He, Xia</creatorcontrib><creatorcontrib>Zhang, Qiu</creatorcontrib><title>Red cell distribution width-to-albumin ratio is a predictor of survival in hepatitis B virus–associated decompensated cirrhosis</title><title>Laboratory medicine</title><addtitle>Lab Med</addtitle><description>Abstract
Objective
The aim of this study was to ascertain whether red cell distribution width-to-albumin ratio (RAR) is associated with survival in hepatitis B virus (HBV)–associated decompensated cirrhosis (DC) patients.
Methods
A cohort of 167 patients with confirmed HBV-DC was enrolled in our study. Demographic characteristics and laboratory data were obtained. The main endpoint was mortality at 30 days. The receiver operating characteristic curve and multivariable regression analysis were used to assess the power of RAR for predicting prognosis.
Results
Mortality at 30 days was 11.4% (19/167). The RAR levels were higher in the nonsurvivors than the survivors, and elevated RAR levels were clearly associated with poor prognosis. Moreover, the predictive powers of RAR and Model for End-Stage Liver Disease score were not obviously different.
Conclusion
Our data indicate that RAR is a novel potential prognostic biomarker of mortality in HBV-DC.</description><subject>Albumins</subject><subject>Biomarkers</subject><subject>End Stage Liver Disease - complications</subject><subject>Erythrocyte Indices</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Humans</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><issn>0007-5027</issn><issn>1943-7730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1O3DAUha0KVAbaLUvkJV2E8U8SO0sYtbTSSEioXUf-i8YoGQdfZxC79hn6hjxJPWRm3dXVPfruOboHoUtKbihp-LJXenB22Q_KklJ-QAvalLwQgpMTtCCEiKIiTJyhc4CnvJZNzT6iMy6YbBrOFujPo7PYuL7H1kOKXk_Jhy1-8TZtihQK1etp8FscVdaxB6zwGJ31JoWIQ4dhiju_Uz3OzMaNmUoZusM7Hyd4-_1XAQTjVcop1pkwjG4L75vxMW4CePiETjvVg_t8mBfo17evP1ffi_XD_Y_V7bowTJapKGtZW9YpVxrGtdOaG9tRJipBldM17ToqHbWSlVrYUglR1a5SHRXaUCmp5hfoevYdY3ieHKR28LD_XG1dmKBl-TRnSF5l9GZGTQwA0XXtGP2g4mtLSbuvvZ1rbw-154Org_f0rh_xY88Z-DIDYRr_Z_YPGHSTJg</recordid><startdate>20240307</startdate><enddate>20240307</enddate><creator>Mao, WeiLin</creator><creator>Yuan, ManChun</creator><creator>He, Xia</creator><creator>Zhang, Qiu</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240307</creationdate><title>Red cell distribution width-to-albumin ratio is a predictor of survival in hepatitis B virus–associated decompensated cirrhosis</title><author>Mao, WeiLin ; Yuan, ManChun ; He, Xia ; Zhang, Qiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-4686d2fae4c23bebb3cdf127571aeb61ff18e1d824b7d4a7756e5af17bc1881b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Albumins</topic><topic>Biomarkers</topic><topic>End Stage Liver Disease - complications</topic><topic>Erythrocyte Indices</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Humans</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mao, WeiLin</creatorcontrib><creatorcontrib>Yuan, ManChun</creatorcontrib><creatorcontrib>He, Xia</creatorcontrib><creatorcontrib>Zhang, Qiu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mao, WeiLin</au><au>Yuan, ManChun</au><au>He, Xia</au><au>Zhang, Qiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red cell distribution width-to-albumin ratio is a predictor of survival in hepatitis B virus–associated decompensated cirrhosis</atitle><jtitle>Laboratory medicine</jtitle><addtitle>Lab Med</addtitle><date>2024-03-07</date><risdate>2024</risdate><volume>55</volume><issue>2</issue><spage>127</spage><epage>131</epage><pages>127-131</pages><issn>0007-5027</issn><eissn>1943-7730</eissn><abstract>Abstract
Objective
The aim of this study was to ascertain whether red cell distribution width-to-albumin ratio (RAR) is associated with survival in hepatitis B virus (HBV)–associated decompensated cirrhosis (DC) patients.
Methods
A cohort of 167 patients with confirmed HBV-DC was enrolled in our study. Demographic characteristics and laboratory data were obtained. The main endpoint was mortality at 30 days. The receiver operating characteristic curve and multivariable regression analysis were used to assess the power of RAR for predicting prognosis.
Results
Mortality at 30 days was 11.4% (19/167). The RAR levels were higher in the nonsurvivors than the survivors, and elevated RAR levels were clearly associated with poor prognosis. Moreover, the predictive powers of RAR and Model for End-Stage Liver Disease score were not obviously different.
Conclusion
Our data indicate that RAR is a novel potential prognostic biomarker of mortality in HBV-DC.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>37289932</pmid><doi>10.1093/labmed/lmad048</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-5027 |
| ispartof | Laboratory medicine, 2024-03, Vol.55 (2), p.127-131 |
| issn | 0007-5027 1943-7730 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Albumins Biomarkers End Stage Liver Disease - complications Erythrocyte Indices Hepatitis B virus Hepatitis B, Chronic - complications Humans Liver Cirrhosis - complications Liver Cirrhosis - diagnosis Prognosis Retrospective Studies Severity of Illness Index |
| title | Red cell distribution width-to-albumin ratio is a predictor of survival in hepatitis B virus–associated decompensated cirrhosis |
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