Statin therapy reduces dementia risk in atrial fibrillation patients receiving oral anticoagulants
Abstract Aims Atrial fibrillation (AF) is linked to an increased risk of dementia, even in stroke-free patients. The impact of statin therapy on dementia risk is unclear in AF patients receiving oral anticoagulant (OAC) (vitamin K antagonist and direct-acting OAC). We sought to investigate the impac...
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| Veröffentlicht in: | European heart journal. Cardiovascular pharmacotherapy 2023-08, Vol.9 (5), p.421-426 |
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| container_title | European heart journal. Cardiovascular pharmacotherapy |
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| creator | Kim, Moo Hyun Yuan, Song Lin Lee, Kwang Min Jin, Xuan Song, Zhao Yan Park, Jong-Sung Cho, Young-Rak Lim, Kyunghee Yun, Sung-Cheol Lee, Michael S Choi, Sun Young |
| description | Abstract
Aims
Atrial fibrillation (AF) is linked to an increased risk of dementia, even in stroke-free patients. The impact of statin therapy on dementia risk is unclear in AF patients receiving oral anticoagulant (OAC) (vitamin K antagonist and direct-acting OAC). We sought to investigate the impact of statin therapy on dementia risk in AF patients receiving OAC.
Methods and results
Using the Korean National Health Insurance Service database, 91 018 non-valvular AF (NVAF) patients from January 2013 to December 2017 were included in the analysis. Of the total, 17 700 patients (19.4%) were in the statin therapy group, and 73 318 patients (80.6%) were in the non-statin therapy group. The primary endpoint was the occurrence of dementia. The median duration of follow-up was 2.1 years. Statin therapy was associated with a significantly lower dementia risk than non-statin therapy for CHA2DS2-VASc scores ≥2 (hazard ratio = 0.77, 95% confidence interval 0.64–0.90, P = 0.026) in NVAF patients receiving OAC. The statin therapy group had a significantly lower dementia risk in a dose-dependent relationship compared with the non-statin therapy group (P for trend |
| doi_str_mv | 10.1093/ehjcvp/pvad039 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2824686231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A775957513</galeid><oup_id>10.1093/ehjcvp/pvad039</oup_id><sourcerecordid>A775957513</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-3e521f559e5672fb1edcdc1141a78be017b097505f96fa713b6c59be4189904c3</originalsourceid><addsrcrecordid>eNqFkc1rGzEQxUVpaYKba45loZfmYEcfq9XqaEzzAYEe2pyFVjty5KxXG2nX4P--Y-ykUAJFhxnE7w2P9wi5ZHTBqBbX8LRxu-F62NmWCv2BnHMq5byqS_nxbRfqjFzkvKGUsqqueC0-kzOhuGaK8nPS_BrtGPpifIJkh32RoJ0c5KKFLfRjsEUK-blAwI4p2K7woUmh61AT-2LAgVRGlYOwC_26iAkhi0oX7XrqcMtfyCdvuwwXpzkjjzc_fq_u5g8_b-9Xy4e5E0qPcwGSMy-lBlkp7hsGrWsdYyWzqm6AMtVQrSSVXlfeKiaaykndQMlqrWnpxIx8P94dUnyZII9mG7IDNNtDnLLhNS8PCQiG6Ld_0E2cUo_ujKCSVpSruvpLrW0HJvQ-jsm6w1GzVEpqqSQTSC3eofBhhJhCDz7g_3sCl2LOCbwZUtjatDeMmkOv5tirOfWKgq8nt1OzhfYNf20RgasjEKfhf8f-AHb9rdg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3050602786</pqid></control><display><type>article</type><title>Statin therapy reduces dementia risk in atrial fibrillation patients receiving oral anticoagulants</title><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Kim, Moo Hyun ; Yuan, Song Lin ; Lee, Kwang Min ; Jin, Xuan ; Song, Zhao Yan ; Park, Jong-Sung ; Cho, Young-Rak ; Lim, Kyunghee ; Yun, Sung-Cheol ; Lee, Michael S ; Choi, Sun Young</creator><creatorcontrib>Kim, Moo Hyun ; Yuan, Song Lin ; Lee, Kwang Min ; Jin, Xuan ; Song, Zhao Yan ; Park, Jong-Sung ; Cho, Young-Rak ; Lim, Kyunghee ; Yun, Sung-Cheol ; Lee, Michael S ; Choi, Sun Young</creatorcontrib><description>Abstract
Aims
Atrial fibrillation (AF) is linked to an increased risk of dementia, even in stroke-free patients. The impact of statin therapy on dementia risk is unclear in AF patients receiving oral anticoagulant (OAC) (vitamin K antagonist and direct-acting OAC). We sought to investigate the impact of statin therapy on dementia risk in AF patients receiving OAC.
Methods and results
Using the Korean National Health Insurance Service database, 91 018 non-valvular AF (NVAF) patients from January 2013 to December 2017 were included in the analysis. Of the total, 17 700 patients (19.4%) were in the statin therapy group, and 73 318 patients (80.6%) were in the non-statin therapy group. The primary endpoint was the occurrence of dementia. The median duration of follow-up was 2.1 years. Statin therapy was associated with a significantly lower dementia risk than non-statin therapy for CHA2DS2-VASc scores ≥2 (hazard ratio = 0.77, 95% confidence interval 0.64–0.90, P = 0.026) in NVAF patients receiving OAC. The statin therapy group had a significantly lower dementia risk in a dose-dependent relationship compared with the non-statin therapy group (P for trend <0.001).
Conclusion
In NVAF patients who received OAC, statin therapy lowered the dementia risk compared with no statin therapy. Furthermore, statin therapy is associated with a dose-dependent reduction in dementia risk.</description><identifier>ISSN: 2055-6837</identifier><identifier>EISSN: 2055-6845</identifier><identifier>DOI: 10.1093/ehjcvp/pvad039</identifier><identifier>PMID: 37291702</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Anticoagulants ; Anticoagulants (Medicine) ; Atrial fibrillation ; Cardiac arrhythmia ; Care and treatment ; Dementia ; Forecasts and trends ; National health insurance ; Risk factors ; Statins</subject><ispartof>European heart journal. Cardiovascular pharmacotherapy, 2023-08, Vol.9 (5), p.421-426</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.</rights><rights>COPYRIGHT 2023 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c379t-3e521f559e5672fb1edcdc1141a78be017b097505f96fa713b6c59be4189904c3</cites><orcidid>0000-0003-3468-6453 ; 0000-0002-7262-1848</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37291702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Moo Hyun</creatorcontrib><creatorcontrib>Yuan, Song Lin</creatorcontrib><creatorcontrib>Lee, Kwang Min</creatorcontrib><creatorcontrib>Jin, Xuan</creatorcontrib><creatorcontrib>Song, Zhao Yan</creatorcontrib><creatorcontrib>Park, Jong-Sung</creatorcontrib><creatorcontrib>Cho, Young-Rak</creatorcontrib><creatorcontrib>Lim, Kyunghee</creatorcontrib><creatorcontrib>Yun, Sung-Cheol</creatorcontrib><creatorcontrib>Lee, Michael S</creatorcontrib><creatorcontrib>Choi, Sun Young</creatorcontrib><title>Statin therapy reduces dementia risk in atrial fibrillation patients receiving oral anticoagulants</title><title>European heart journal. Cardiovascular pharmacotherapy</title><addtitle>Eur Heart J Cardiovasc Pharmacother</addtitle><description>Abstract
Aims
Atrial fibrillation (AF) is linked to an increased risk of dementia, even in stroke-free patients. The impact of statin therapy on dementia risk is unclear in AF patients receiving oral anticoagulant (OAC) (vitamin K antagonist and direct-acting OAC). We sought to investigate the impact of statin therapy on dementia risk in AF patients receiving OAC.
Methods and results
Using the Korean National Health Insurance Service database, 91 018 non-valvular AF (NVAF) patients from January 2013 to December 2017 were included in the analysis. Of the total, 17 700 patients (19.4%) were in the statin therapy group, and 73 318 patients (80.6%) were in the non-statin therapy group. The primary endpoint was the occurrence of dementia. The median duration of follow-up was 2.1 years. Statin therapy was associated with a significantly lower dementia risk than non-statin therapy for CHA2DS2-VASc scores ≥2 (hazard ratio = 0.77, 95% confidence interval 0.64–0.90, P = 0.026) in NVAF patients receiving OAC. The statin therapy group had a significantly lower dementia risk in a dose-dependent relationship compared with the non-statin therapy group (P for trend <0.001).
Conclusion
In NVAF patients who received OAC, statin therapy lowered the dementia risk compared with no statin therapy. Furthermore, statin therapy is associated with a dose-dependent reduction in dementia risk.</description><subject>Anticoagulants</subject><subject>Anticoagulants (Medicine)</subject><subject>Atrial fibrillation</subject><subject>Cardiac arrhythmia</subject><subject>Care and treatment</subject><subject>Dementia</subject><subject>Forecasts and trends</subject><subject>National health insurance</subject><subject>Risk factors</subject><subject>Statins</subject><issn>2055-6837</issn><issn>2055-6845</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqFkc1rGzEQxUVpaYKba45loZfmYEcfq9XqaEzzAYEe2pyFVjty5KxXG2nX4P--Y-ykUAJFhxnE7w2P9wi5ZHTBqBbX8LRxu-F62NmWCv2BnHMq5byqS_nxbRfqjFzkvKGUsqqueC0-kzOhuGaK8nPS_BrtGPpifIJkh32RoJ0c5KKFLfRjsEUK-blAwI4p2K7woUmh61AT-2LAgVRGlYOwC_26iAkhi0oX7XrqcMtfyCdvuwwXpzkjjzc_fq_u5g8_b-9Xy4e5E0qPcwGSMy-lBlkp7hsGrWsdYyWzqm6AMtVQrSSVXlfeKiaaykndQMlqrWnpxIx8P94dUnyZII9mG7IDNNtDnLLhNS8PCQiG6Ld_0E2cUo_ujKCSVpSruvpLrW0HJvQ-jsm6w1GzVEpqqSQTSC3eofBhhJhCDz7g_3sCl2LOCbwZUtjatDeMmkOv5tirOfWKgq8nt1OzhfYNf20RgasjEKfhf8f-AHb9rdg</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Kim, Moo Hyun</creator><creator>Yuan, Song Lin</creator><creator>Lee, Kwang Min</creator><creator>Jin, Xuan</creator><creator>Song, Zhao Yan</creator><creator>Park, Jong-Sung</creator><creator>Cho, Young-Rak</creator><creator>Lim, Kyunghee</creator><creator>Yun, Sung-Cheol</creator><creator>Lee, Michael S</creator><creator>Choi, Sun Young</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3468-6453</orcidid><orcidid>https://orcid.org/0000-0002-7262-1848</orcidid></search><sort><creationdate>20230801</creationdate><title>Statin therapy reduces dementia risk in atrial fibrillation patients receiving oral anticoagulants</title><author>Kim, Moo Hyun ; Yuan, Song Lin ; Lee, Kwang Min ; Jin, Xuan ; Song, Zhao Yan ; Park, Jong-Sung ; Cho, Young-Rak ; Lim, Kyunghee ; Yun, Sung-Cheol ; Lee, Michael S ; Choi, Sun Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-3e521f559e5672fb1edcdc1141a78be017b097505f96fa713b6c59be4189904c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anticoagulants</topic><topic>Anticoagulants (Medicine)</topic><topic>Atrial fibrillation</topic><topic>Cardiac arrhythmia</topic><topic>Care and treatment</topic><topic>Dementia</topic><topic>Forecasts and trends</topic><topic>National health insurance</topic><topic>Risk factors</topic><topic>Statins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Moo Hyun</creatorcontrib><creatorcontrib>Yuan, Song Lin</creatorcontrib><creatorcontrib>Lee, Kwang Min</creatorcontrib><creatorcontrib>Jin, Xuan</creatorcontrib><creatorcontrib>Song, Zhao Yan</creatorcontrib><creatorcontrib>Park, Jong-Sung</creatorcontrib><creatorcontrib>Cho, Young-Rak</creatorcontrib><creatorcontrib>Lim, Kyunghee</creatorcontrib><creatorcontrib>Yun, Sung-Cheol</creatorcontrib><creatorcontrib>Lee, Michael S</creatorcontrib><creatorcontrib>Choi, Sun Young</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal. Cardiovascular pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Moo Hyun</au><au>Yuan, Song Lin</au><au>Lee, Kwang Min</au><au>Jin, Xuan</au><au>Song, Zhao Yan</au><au>Park, Jong-Sung</au><au>Cho, Young-Rak</au><au>Lim, Kyunghee</au><au>Yun, Sung-Cheol</au><au>Lee, Michael S</au><au>Choi, Sun Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statin therapy reduces dementia risk in atrial fibrillation patients receiving oral anticoagulants</atitle><jtitle>European heart journal. Cardiovascular pharmacotherapy</jtitle><addtitle>Eur Heart J Cardiovasc Pharmacother</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>9</volume><issue>5</issue><spage>421</spage><epage>426</epage><pages>421-426</pages><issn>2055-6837</issn><eissn>2055-6845</eissn><abstract>Abstract
Aims
Atrial fibrillation (AF) is linked to an increased risk of dementia, even in stroke-free patients. The impact of statin therapy on dementia risk is unclear in AF patients receiving oral anticoagulant (OAC) (vitamin K antagonist and direct-acting OAC). We sought to investigate the impact of statin therapy on dementia risk in AF patients receiving OAC.
Methods and results
Using the Korean National Health Insurance Service database, 91 018 non-valvular AF (NVAF) patients from January 2013 to December 2017 were included in the analysis. Of the total, 17 700 patients (19.4%) were in the statin therapy group, and 73 318 patients (80.6%) were in the non-statin therapy group. The primary endpoint was the occurrence of dementia. The median duration of follow-up was 2.1 years. Statin therapy was associated with a significantly lower dementia risk than non-statin therapy for CHA2DS2-VASc scores ≥2 (hazard ratio = 0.77, 95% confidence interval 0.64–0.90, P = 0.026) in NVAF patients receiving OAC. The statin therapy group had a significantly lower dementia risk in a dose-dependent relationship compared with the non-statin therapy group (P for trend <0.001).
Conclusion
In NVAF patients who received OAC, statin therapy lowered the dementia risk compared with no statin therapy. Furthermore, statin therapy is associated with a dose-dependent reduction in dementia risk.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>37291702</pmid><doi>10.1093/ehjcvp/pvad039</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3468-6453</orcidid><orcidid>https://orcid.org/0000-0002-7262-1848</orcidid></addata></record> |
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| identifier | ISSN: 2055-6837 |
| ispartof | European heart journal. Cardiovascular pharmacotherapy, 2023-08, Vol.9 (5), p.421-426 |
| issn | 2055-6837 2055-6845 |
| language | eng |
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| source | PubMed Central; Alma/SFX Local Collection |
| subjects | Anticoagulants Anticoagulants (Medicine) Atrial fibrillation Cardiac arrhythmia Care and treatment Dementia Forecasts and trends National health insurance Risk factors Statins |
| title | Statin therapy reduces dementia risk in atrial fibrillation patients receiving oral anticoagulants |
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