The pyrimidinosome is cancer’s Achilles’ heel
A new study shows that the enzymes involved in de novo pyrimidine synthesis and ferroptosis form a complex called the pyrimidinosome, which is controlled by AMPK. Cancer cells low in AMPK expression rely on the pyrimidinosome, suggesting that co-inhibition of AMPK and the pyrimidinosome represents a...
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| Veröffentlicht in: | Nature cell biology 2023-06, Vol.25 (6), p.798-799 |
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| container_title | Nature cell biology |
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| creator | Dodson, Matthew Zhang, Donna D. |
| description | A new study shows that the enzymes involved in de novo pyrimidine synthesis and ferroptosis form a complex called the pyrimidinosome, which is controlled by AMPK. Cancer cells low in AMPK expression rely on the pyrimidinosome, suggesting that co-inhibition of AMPK and the pyrimidinosome represents a potential cancer treatment strategy. |
| doi_str_mv | 10.1038/s41556-023-01159-z |
| format | Article |
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| subjects | 631/67/2327 631/80/82 631/80/83 Apoptosis Biology Biomedical and Life Sciences Cancer Cancer Research Cancer therapies Cell Biology Cell growth Chemical reactions Developmental Biology Enzymes Ferroptosis Humans Life Sciences Neoplasms - genetics News & Views news-and-views Pharmacy Proteins Stem Cells |
| title | The pyrimidinosome is cancer’s Achilles’ heel |
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