The protective effect of 7-hydroxycoumarin against cisplatin-induced liver injury is mediated via attenuation of oxidative stress and inflammation and upregulation of Nrf2/HO-1 pathway

Cisplatin (CIS) is an effective chemotherapy against different solid cancers. However, the adverse effects, including hepatotoxicity, limit its clinical use. 7-hydroxycoumarin (7-HC) possesses antioxidant and hepatoprotective activities, but its protective effect against CIS hepatotoxicity has not b...

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Veröffentlicht in:	Environmental science and pollution research international 2023-07, Vol.30 (33), p.80181-80191
Hauptverfasser:	Sami, Demiana H., Soliman, Ayman S., Khowailed, Akef A., Alruhaimi, Reem S., Hassanein, Emad H. M., Kamel, Emadeldin M., Mahmoud, Ayman M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Animals Antioxidants Antioxidants - metabolism Apoptosis Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bcl-2 protein Bilirubin Caspase-3 Chemical and Drug Induced Liver Injury, Chronic - drug therapy Chemotherapy Cisplatin Cisplatin - toxicity Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Heme oxygenase (decyclizing) Hepatotoxicity Inflammation Inflammation - metabolism Inflammatory response Injury prevention Liver NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Nitric oxide Nitric-oxide synthase Oxidative Stress Rats Reactive oxygen species Research Article Umbelliferones - pharmacology Up-Regulation Waste Water Technology Water Management Water Pollution Control
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