Serotypes and antimicrobial resistance of Streptococcus pneumoniae in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay
remains a major cause of mortality and morbidity worldwide in children
Gespeichert in:
| Veröffentlicht in: | Journal of medical microbiology 2023-06, Vol.72 (6) |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | |
| container_title | Journal of medical microbiology |
| container_volume | 72 |
| creator | León, María Eugenia Samudio, Margarita Kawabata, Aníbal Nagai, Minako Rojas, Liliana Zárate, Noemí Irala, Juan Leguizamón, Myrian Gómez, Gloria Ortellado, Juana Blasco, Raquel Franco, Rossana Chamorro, Gustavo |
| description | remains a major cause of mortality and morbidity worldwide in children |
| doi_str_mv | 10.1099/jmm.0.001700 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2823989209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2823989209</sourcerecordid><originalsourceid>FETCH-LOGICAL-c248t-41620645209638d77f1cbc429341d57225ee0ca63ce26ad95c3afb7dd096a2fc3</originalsourceid><addsrcrecordid>eNo9kcuO1DAQRS0EYnoGdqyRlyxI41ceXqIRj5FGAmlgHVWXK41biR1sB6k_ib8koQcWpdqce0qqy9grKfZSWPvuNE17sRdCtkI8YTtpWl3VjTFP2U4IpSrVyPqKXed82hit7XN2pVvVWdPpHfv9QCmW80yZQ3DrFD95TPHgYeSJss8FAhKPA38oieYSMSIumc-BlikGD8R94PjDjy5R4EtwlHjNzwQpbyk4Ep8TVX_1c8yluiQ3zXoCYzgtRyjEfwGiD5utpOgWLD6GTf0VEhwXOL9gzwYYM7183Dfs-8cP324_V_dfPt3dvr-vUJmuVEY2SjSmVsI2unNtO0g8oFFWG-nqVqmaSCA0Gkk14GyNGoZD69zKgxpQ37A3F--c4s-Fcuknn5HGEQLFJfeqU9p2dvWv6NsLuj4s50RDPyc_QTr3UvRbOf1aTi_6Szkr_vrRvBwmcv_hf23oP2mpjqw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2823989209</pqid></control><display><type>article</type><title>Serotypes and antimicrobial resistance of Streptococcus pneumoniae in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay</title><source>MEDLINE</source><source>Microbiology Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>León, María Eugenia ; Samudio, Margarita ; Kawabata, Aníbal ; Nagai, Minako ; Rojas, Liliana ; Zárate, Noemí ; Irala, Juan ; Leguizamón, Myrian ; Gómez, Gloria ; Ortellado, Juana ; Blasco, Raquel ; Franco, Rossana ; Chamorro, Gustavo</creator><creatorcontrib>León, María Eugenia ; Samudio, Margarita ; Kawabata, Aníbal ; Nagai, Minako ; Rojas, Liliana ; Zárate, Noemí ; Irala, Juan ; Leguizamón, Myrian ; Gómez, Gloria ; Ortellado, Juana ; Blasco, Raquel ; Franco, Rossana ; Chamorro, Gustavo</creatorcontrib><description>remains a major cause of mortality and morbidity worldwide in children <5 years of age, even with advances in vaccination programmes.
Reviewing and reporting trends in the distribution of pneumococcal serotypes and antimicrobial resistance in Paraguay will be useful for decision-making in public health.
. This study analysed the serotype distribution and antimicrobial resistance of
and the characteristics of pneumococcal disease in children <5 years old before and after the introduction of pneumococcal conjugate vaccines (PCVs).
A total of 885 isolates and 278
PCR-positive clinical specimens were referred to the Central Laboratory of Public Health (LCSP) within the meningitis and pneumonia laboratory based-surveillance network in the period 2006-2020. Conventional and molecular microbiological techniques were used for confirmation and characterization.
We identified 563 cases of pneumococcal disease in the pre-vaccination period, 325 cases in the post-PCV10 period and 275 cases in the post-PCV13 period. The serotypes covered by PCV10 decreased from 78.6-6.5 %. However, additional serotypes covered by PCV13 increased from 6.6-57.5% and non-PCV13 serotypes increased from 14.8-36.0 % (
<0.001) in the post-PCV13 period. In cases of meningitis, the rate of resistance to penicillin decreased after the introduction of conjugate vaccines. No resistance to ceftriaxone was found in any period. In cases without meningitis, the rate of resistance to penicillin and ceftriaxone decreased slightly. However, the rate of resistance to erythromycin and tetracycline increased and that to trimethoprim-sulfamethoxazole (SXT) decreased in the post-PCV13 period compared to the pre-PCV period. The multidrug resistance rate was 8.5 %.
A change in the circulating serotypes and antimicrobial resistance to certain antibiotics was observed. Non-vaccine serotype circulation and multidrug resistance may compromise the success of the conjugate vaccines.</description><identifier>ISSN: 0022-2615</identifier><identifier>EISSN: 1473-5644</identifier><identifier>DOI: 10.1099/jmm.0.001700</identifier><identifier>PMID: 37289483</identifier><language>eng</language><publisher>England</publisher><subject>Anti-Bacterial Agents - pharmacology ; Ceftriaxone ; Child ; Child, Preschool ; Drug Resistance, Bacterial ; Humans ; Infant ; Paraguay - epidemiology ; Penicillins ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - microbiology ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines ; Serogroup ; Streptococcus pneumoniae ; Vaccines, Conjugate</subject><ispartof>Journal of medical microbiology, 2023-06, Vol.72 (6)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c248t-41620645209638d77f1cbc429341d57225ee0ca63ce26ad95c3afb7dd096a2fc3</cites><orcidid>0000-0001-7416-249X ; 0000-0001-7244-5410 ; 0000-0003-0352-5681 ; 0000-0002-8188-878X ; 0000-0002-7231-3204 ; 0000-0003-3959-1533 ; 0000-0002-7806-8289 ; 0000-0003-1808-847X ; 0000-0002-9405-0724 ; 0000-0003-2813-218X ; 0000-0002-1825-4194 ; 0000-0002-3960-435X ; 0000-0003-4099-0128</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3746,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37289483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>León, María Eugenia</creatorcontrib><creatorcontrib>Samudio, Margarita</creatorcontrib><creatorcontrib>Kawabata, Aníbal</creatorcontrib><creatorcontrib>Nagai, Minako</creatorcontrib><creatorcontrib>Rojas, Liliana</creatorcontrib><creatorcontrib>Zárate, Noemí</creatorcontrib><creatorcontrib>Irala, Juan</creatorcontrib><creatorcontrib>Leguizamón, Myrian</creatorcontrib><creatorcontrib>Gómez, Gloria</creatorcontrib><creatorcontrib>Ortellado, Juana</creatorcontrib><creatorcontrib>Blasco, Raquel</creatorcontrib><creatorcontrib>Franco, Rossana</creatorcontrib><creatorcontrib>Chamorro, Gustavo</creatorcontrib><title>Serotypes and antimicrobial resistance of Streptococcus pneumoniae in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay</title><title>Journal of medical microbiology</title><addtitle>J Med Microbiol</addtitle><description>remains a major cause of mortality and morbidity worldwide in children <5 years of age, even with advances in vaccination programmes.
Reviewing and reporting trends in the distribution of pneumococcal serotypes and antimicrobial resistance in Paraguay will be useful for decision-making in public health.
. This study analysed the serotype distribution and antimicrobial resistance of
and the characteristics of pneumococcal disease in children <5 years old before and after the introduction of pneumococcal conjugate vaccines (PCVs).
A total of 885 isolates and 278
PCR-positive clinical specimens were referred to the Central Laboratory of Public Health (LCSP) within the meningitis and pneumonia laboratory based-surveillance network in the period 2006-2020. Conventional and molecular microbiological techniques were used for confirmation and characterization.
We identified 563 cases of pneumococcal disease in the pre-vaccination period, 325 cases in the post-PCV10 period and 275 cases in the post-PCV13 period. The serotypes covered by PCV10 decreased from 78.6-6.5 %. However, additional serotypes covered by PCV13 increased from 6.6-57.5% and non-PCV13 serotypes increased from 14.8-36.0 % (
<0.001) in the post-PCV13 period. In cases of meningitis, the rate of resistance to penicillin decreased after the introduction of conjugate vaccines. No resistance to ceftriaxone was found in any period. In cases without meningitis, the rate of resistance to penicillin and ceftriaxone decreased slightly. However, the rate of resistance to erythromycin and tetracycline increased and that to trimethoprim-sulfamethoxazole (SXT) decreased in the post-PCV13 period compared to the pre-PCV period. The multidrug resistance rate was 8.5 %.
A change in the circulating serotypes and antimicrobial resistance to certain antibiotics was observed. Non-vaccine serotype circulation and multidrug resistance may compromise the success of the conjugate vaccines.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Ceftriaxone</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Resistance, Bacterial</subject><subject>Humans</subject><subject>Infant</subject><subject>Paraguay - epidemiology</subject><subject>Penicillins</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Infections - microbiology</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal Vaccines</subject><subject>Serogroup</subject><subject>Streptococcus pneumoniae</subject><subject>Vaccines, Conjugate</subject><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kcuO1DAQRS0EYnoGdqyRlyxI41ceXqIRj5FGAmlgHVWXK41biR1sB6k_ib8koQcWpdqce0qqy9grKfZSWPvuNE17sRdCtkI8YTtpWl3VjTFP2U4IpSrVyPqKXed82hit7XN2pVvVWdPpHfv9QCmW80yZQ3DrFD95TPHgYeSJss8FAhKPA38oieYSMSIumc-BlikGD8R94PjDjy5R4EtwlHjNzwQpbyk4Ep8TVX_1c8yluiQ3zXoCYzgtRyjEfwGiD5utpOgWLD6GTf0VEhwXOL9gzwYYM7183Dfs-8cP324_V_dfPt3dvr-vUJmuVEY2SjSmVsI2unNtO0g8oFFWG-nqVqmaSCA0Gkk14GyNGoZD69zKgxpQ37A3F--c4s-Fcuknn5HGEQLFJfeqU9p2dvWv6NsLuj4s50RDPyc_QTr3UvRbOf1aTi_6Szkr_vrRvBwmcv_hf23oP2mpjqw</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>León, María Eugenia</creator><creator>Samudio, Margarita</creator><creator>Kawabata, Aníbal</creator><creator>Nagai, Minako</creator><creator>Rojas, Liliana</creator><creator>Zárate, Noemí</creator><creator>Irala, Juan</creator><creator>Leguizamón, Myrian</creator><creator>Gómez, Gloria</creator><creator>Ortellado, Juana</creator><creator>Blasco, Raquel</creator><creator>Franco, Rossana</creator><creator>Chamorro, Gustavo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7416-249X</orcidid><orcidid>https://orcid.org/0000-0001-7244-5410</orcidid><orcidid>https://orcid.org/0000-0003-0352-5681</orcidid><orcidid>https://orcid.org/0000-0002-8188-878X</orcidid><orcidid>https://orcid.org/0000-0002-7231-3204</orcidid><orcidid>https://orcid.org/0000-0003-3959-1533</orcidid><orcidid>https://orcid.org/0000-0002-7806-8289</orcidid><orcidid>https://orcid.org/0000-0003-1808-847X</orcidid><orcidid>https://orcid.org/0000-0002-9405-0724</orcidid><orcidid>https://orcid.org/0000-0003-2813-218X</orcidid><orcidid>https://orcid.org/0000-0002-1825-4194</orcidid><orcidid>https://orcid.org/0000-0002-3960-435X</orcidid><orcidid>https://orcid.org/0000-0003-4099-0128</orcidid></search><sort><creationdate>202306</creationdate><title>Serotypes and antimicrobial resistance of Streptococcus pneumoniae in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay</title><author>León, María Eugenia ; Samudio, Margarita ; Kawabata, Aníbal ; Nagai, Minako ; Rojas, Liliana ; Zárate, Noemí ; Irala, Juan ; Leguizamón, Myrian ; Gómez, Gloria ; Ortellado, Juana ; Blasco, Raquel ; Franco, Rossana ; Chamorro, Gustavo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c248t-41620645209638d77f1cbc429341d57225ee0ca63ce26ad95c3afb7dd096a2fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Ceftriaxone</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Resistance, Bacterial</topic><topic>Humans</topic><topic>Infant</topic><topic>Paraguay - epidemiology</topic><topic>Penicillins</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Pneumococcal Infections - microbiology</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumococcal Vaccines</topic><topic>Serogroup</topic><topic>Streptococcus pneumoniae</topic><topic>Vaccines, Conjugate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>León, María Eugenia</creatorcontrib><creatorcontrib>Samudio, Margarita</creatorcontrib><creatorcontrib>Kawabata, Aníbal</creatorcontrib><creatorcontrib>Nagai, Minako</creatorcontrib><creatorcontrib>Rojas, Liliana</creatorcontrib><creatorcontrib>Zárate, Noemí</creatorcontrib><creatorcontrib>Irala, Juan</creatorcontrib><creatorcontrib>Leguizamón, Myrian</creatorcontrib><creatorcontrib>Gómez, Gloria</creatorcontrib><creatorcontrib>Ortellado, Juana</creatorcontrib><creatorcontrib>Blasco, Raquel</creatorcontrib><creatorcontrib>Franco, Rossana</creatorcontrib><creatorcontrib>Chamorro, Gustavo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>León, María Eugenia</au><au>Samudio, Margarita</au><au>Kawabata, Aníbal</au><au>Nagai, Minako</au><au>Rojas, Liliana</au><au>Zárate, Noemí</au><au>Irala, Juan</au><au>Leguizamón, Myrian</au><au>Gómez, Gloria</au><au>Ortellado, Juana</au><au>Blasco, Raquel</au><au>Franco, Rossana</au><au>Chamorro, Gustavo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotypes and antimicrobial resistance of Streptococcus pneumoniae in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay</atitle><jtitle>Journal of medical microbiology</jtitle><addtitle>J Med Microbiol</addtitle><date>2023-06</date><risdate>2023</risdate><volume>72</volume><issue>6</issue><issn>0022-2615</issn><eissn>1473-5644</eissn><abstract>remains a major cause of mortality and morbidity worldwide in children <5 years of age, even with advances in vaccination programmes.
Reviewing and reporting trends in the distribution of pneumococcal serotypes and antimicrobial resistance in Paraguay will be useful for decision-making in public health.
. This study analysed the serotype distribution and antimicrobial resistance of
and the characteristics of pneumococcal disease in children <5 years old before and after the introduction of pneumococcal conjugate vaccines (PCVs).
A total of 885 isolates and 278
PCR-positive clinical specimens were referred to the Central Laboratory of Public Health (LCSP) within the meningitis and pneumonia laboratory based-surveillance network in the period 2006-2020. Conventional and molecular microbiological techniques were used for confirmation and characterization.
We identified 563 cases of pneumococcal disease in the pre-vaccination period, 325 cases in the post-PCV10 period and 275 cases in the post-PCV13 period. The serotypes covered by PCV10 decreased from 78.6-6.5 %. However, additional serotypes covered by PCV13 increased from 6.6-57.5% and non-PCV13 serotypes increased from 14.8-36.0 % (
<0.001) in the post-PCV13 period. In cases of meningitis, the rate of resistance to penicillin decreased after the introduction of conjugate vaccines. No resistance to ceftriaxone was found in any period. In cases without meningitis, the rate of resistance to penicillin and ceftriaxone decreased slightly. However, the rate of resistance to erythromycin and tetracycline increased and that to trimethoprim-sulfamethoxazole (SXT) decreased in the post-PCV13 period compared to the pre-PCV period. The multidrug resistance rate was 8.5 %.
A change in the circulating serotypes and antimicrobial resistance to certain antibiotics was observed. Non-vaccine serotype circulation and multidrug resistance may compromise the success of the conjugate vaccines.</abstract><cop>England</cop><pmid>37289483</pmid><doi>10.1099/jmm.0.001700</doi><orcidid>https://orcid.org/0000-0001-7416-249X</orcidid><orcidid>https://orcid.org/0000-0001-7244-5410</orcidid><orcidid>https://orcid.org/0000-0003-0352-5681</orcidid><orcidid>https://orcid.org/0000-0002-8188-878X</orcidid><orcidid>https://orcid.org/0000-0002-7231-3204</orcidid><orcidid>https://orcid.org/0000-0003-3959-1533</orcidid><orcidid>https://orcid.org/0000-0002-7806-8289</orcidid><orcidid>https://orcid.org/0000-0003-1808-847X</orcidid><orcidid>https://orcid.org/0000-0002-9405-0724</orcidid><orcidid>https://orcid.org/0000-0003-2813-218X</orcidid><orcidid>https://orcid.org/0000-0002-1825-4194</orcidid><orcidid>https://orcid.org/0000-0002-3960-435X</orcidid><orcidid>https://orcid.org/0000-0003-4099-0128</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2615 |
| ispartof | Journal of medical microbiology, 2023-06, Vol.72 (6) |
| issn | 0022-2615 1473-5644 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2823989209 |
| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - pharmacology Ceftriaxone Child Child, Preschool Drug Resistance, Bacterial Humans Infant Paraguay - epidemiology Penicillins Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines Serogroup Streptococcus pneumoniae Vaccines, Conjugate |
| title | Serotypes and antimicrobial resistance of Streptococcus pneumoniae in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T00%3A40%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serotypes%20and%20antimicrobial%20resistance%20of%20Streptococcus%20pneumoniae%20in%20children%20under%205%20years%20of%20age%20pre-%20and%20post-pneumococcal%20conjugate%20vaccine%20introduction%20in%20Paraguay&rft.jtitle=Journal%20of%20medical%20microbiology&rft.au=Le%C3%B3n,%20Mar%C3%ADa%20Eugenia&rft.date=2023-06&rft.volume=72&rft.issue=6&rft.issn=0022-2615&rft.eissn=1473-5644&rft_id=info:doi/10.1099/jmm.0.001700&rft_dat=%3Cproquest_cross%3E2823989209%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2823989209&rft_id=info:pmid/37289483&rfr_iscdi=true |