CCL20 inhibition for treating inflammation in ankylosing spondylitis

Abstract Objectives Th17 cells are known to play a significant role in AS. C-C motif chemokine ligand 20 (CCL20) binds to C-C chemokine receptor 6 (CCR6) on Th17 cells, promoting their migration to inflammation sites. The aim of this research is to examine the effectiveness of CCL20 inhibition in tr...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2023-12, Vol.62 (12), p.4000-4005
Hauptverfasser:	Won, Eun Jeong, Kim, Hui-Ju, Lee, Yu Jeong, Kim, Moon-Ju, Lee, Hae-In, Jang, Hyun Hee, Kim, Seong Hoon, Kang, Ji-Hyoun, Park, Ki-Jeong, Shim, Seung Cheol, Jo, Sungsin, Kim, Tae-Hwan, Kim, Tae-Jong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemokine CCL20 - metabolism Disease Models, Animal Humans Inflammation - drug therapy Inflammation - metabolism Leukocytes, Mononuclear - metabolism Ligands Mice Receptors, CCR6 - metabolism Spondylitis, Ankylosing - metabolism Th17 Cells - metabolism
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