Specific Developmental Defects in Molluscs after Treatment with Retinoic Acid during Gastrulation
All‐trans retinoic acid is known as a teratogen in vertebrate development. To study whether molluscan morphogenesis is sensitive to retinoic acid, the development of Lymnaea stagnalis, Physa fontinalis and Bithynia tentaculata was examined after treatment with retinoic acid. Low concentrations retin...
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| Veröffentlicht in: | Development, growth & differentiation growth & differentiation, 1993-06, Vol.35 (3), p.357-364 |
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| creator | Créton, Robbert Zwaan, Gideon Dohmen, René |
| description | All‐trans retinoic acid is known as a teratogen in vertebrate development. To study whether molluscan morphogenesis is sensitive to retinoic acid, the development of Lymnaea stagnalis, Physa fontinalis and Bithynia tentaculata was examined after treatment with retinoic acid. Low concentrations retinoic acid (10–7M) specifically affected eye formation in each of these species. In Lymnaea, it was shown that 10–6M retinoic acid resulted in a wider spectrum of deficiencies, including eye defects, arrested development and shell deformations. Pulse treatments revealed that embryos were most sensitive during gastrulation. Soon after gastrulation the embryos had lost their sensitivity to retinoic acid, which indicates that the observed defects do not result from a general non‐specific toxic effect on cells. Even though molluscan development differs in numerous respects from vertebrate development, the present results suggest that molluscs share common features with vertebrates in morphogenetic processes that operate in early development. |
| doi_str_mv | 10.1111/j.1440-169X.1993.00357.x |
| format | Article |
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To study whether molluscan morphogenesis is sensitive to retinoic acid, the development of Lymnaea stagnalis, Physa fontinalis and Bithynia tentaculata was examined after treatment with retinoic acid. Low concentrations retinoic acid (10–7M) specifically affected eye formation in each of these species. In Lymnaea, it was shown that 10–6M retinoic acid resulted in a wider spectrum of deficiencies, including eye defects, arrested development and shell deformations. Pulse treatments revealed that embryos were most sensitive during gastrulation. Soon after gastrulation the embryos had lost their sensitivity to retinoic acid, which indicates that the observed defects do not result from a general non‐specific toxic effect on cells. Even though molluscan development differs in numerous respects from vertebrate development, the present results suggest that molluscs share common features with vertebrates in morphogenetic processes that operate in early development.</description><identifier>ISSN: 0012-1592</identifier><identifier>EISSN: 1440-169X</identifier><identifier>DOI: 10.1111/j.1440-169X.1993.00357.x</identifier><identifier>PMID: 37281632</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Bithynia tentaculata ; Fundamental and applied biological sciences. Psychology ; Invertebrates ; Life cycle. Embryology. Development ; Lymnaea stagnalis ; Marine ; Mollusca ; Physa fontinalis ; Physiology. 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To study whether molluscan morphogenesis is sensitive to retinoic acid, the development of Lymnaea stagnalis, Physa fontinalis and Bithynia tentaculata was examined after treatment with retinoic acid. Low concentrations retinoic acid (10–7M) specifically affected eye formation in each of these species. In Lymnaea, it was shown that 10–6M retinoic acid resulted in a wider spectrum of deficiencies, including eye defects, arrested development and shell deformations. Pulse treatments revealed that embryos were most sensitive during gastrulation. Soon after gastrulation the embryos had lost their sensitivity to retinoic acid, which indicates that the observed defects do not result from a general non‐specific toxic effect on cells. Even though molluscan development differs in numerous respects from vertebrate development, the present results suggest that molluscs share common features with vertebrates in morphogenetic processes that operate in early development.</description><subject>Biological and medical sciences</subject><subject>Bithynia tentaculata</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Invertebrates</subject><subject>Life cycle. Embryology. Development</subject><subject>Lymnaea stagnalis</subject><subject>Marine</subject><subject>Mollusca</subject><subject>Physa fontinalis</subject><subject>Physiology. Development</subject><issn>0012-1592</issn><issn>1440-169X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNp90U1r3DAQBmBRWppN2r8QdAilF7ujL8uGXEK23RZSCkkKvQmtPE60aO2NJTfJv4_cbENP1UUa5pEQ8xJCGZQsr0-bkkkJBauaXyVrGlECCKXLh1dk8dJ4TRYAjBdMNfyAHMa4AQApGX9LDoTmNasEXxB7tUPnO-_oEn9jGHZb7JMNuerQpUh9T78PIUzRRWq7hCO9HtGmWdF7n27pJSbfD_n-mfMtbafR9zd0ZWMap2CTH_p35E1nQ8T3-_2I_Pzy-fr8a3HxY_Xt_OyicFxLXayr2mkLXDAhQWElsMWqq7pGgLU11lxXUkGrWtD5664VGlG5eu2YlR0qKY7Ix-d3d-NwN2FMZuujwxBsj8MUDa-5kI2Ghmf64b-UVbXQCliGx3s4rbfYmt3ot3Z8NH_nl8HJHtjobOhG2zsf_3GaC1VndvrM7n3Ax5c2AzPHaTZmTs3MqZk5TvMnTvNglqtlPogn5d2S8Q</recordid><startdate>199306</startdate><enddate>199306</enddate><creator>Créton, Robbert</creator><creator>Zwaan, Gideon</creator><creator>Dohmen, René</creator><general>Blackwell Publishing Ltd</general><general>Japanese Society of Developmental Biologists</general><scope>IQODW</scope><scope>NPM</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>199306</creationdate><title>Specific Developmental Defects in Molluscs after Treatment with Retinoic Acid during Gastrulation</title><author>Créton, Robbert ; Zwaan, Gideon ; Dohmen, René</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2747-b68c7a02313405e63ede6f6f930aa8e8276450d5d07816cd37ee5c8bc1a4fe543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>Bithynia tentaculata</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Invertebrates</topic><topic>Life cycle. Embryology. Development</topic><topic>Lymnaea stagnalis</topic><topic>Marine</topic><topic>Mollusca</topic><topic>Physa fontinalis</topic><topic>Physiology. Development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Créton, Robbert</creatorcontrib><creatorcontrib>Zwaan, Gideon</creatorcontrib><creatorcontrib>Dohmen, René</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Development, growth & differentiation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Créton, Robbert</au><au>Zwaan, Gideon</au><au>Dohmen, René</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific Developmental Defects in Molluscs after Treatment with Retinoic Acid during Gastrulation</atitle><jtitle>Development, growth & differentiation</jtitle><addtitle>Dev Growth Differ</addtitle><date>1993-06</date><risdate>1993</risdate><volume>35</volume><issue>3</issue><spage>357</spage><epage>364</epage><pages>357-364</pages><issn>0012-1592</issn><eissn>1440-169X</eissn><abstract>All‐trans retinoic acid is known as a teratogen in vertebrate development. To study whether molluscan morphogenesis is sensitive to retinoic acid, the development of Lymnaea stagnalis, Physa fontinalis and Bithynia tentaculata was examined after treatment with retinoic acid. Low concentrations retinoic acid (10–7M) specifically affected eye formation in each of these species. In Lymnaea, it was shown that 10–6M retinoic acid resulted in a wider spectrum of deficiencies, including eye defects, arrested development and shell deformations. Pulse treatments revealed that embryos were most sensitive during gastrulation. Soon after gastrulation the embryos had lost their sensitivity to retinoic acid, which indicates that the observed defects do not result from a general non‐specific toxic effect on cells. Even though molluscan development differs in numerous respects from vertebrate development, the present results suggest that molluscs share common features with vertebrates in morphogenetic processes that operate in early development.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>37281632</pmid><doi>10.1111/j.1440-169X.1993.00357.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Development, growth & differentiation, 1993-06, Vol.35 (3), p.357-364 |
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| language | eng |
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| source | Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Bithynia tentaculata Fundamental and applied biological sciences. Psychology Invertebrates Life cycle. Embryology. Development Lymnaea stagnalis Marine Mollusca Physa fontinalis Physiology. Development |
| title | Specific Developmental Defects in Molluscs after Treatment with Retinoic Acid during Gastrulation |
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