Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?
Growing evidence supports the suggestion that the peripheral immune system plays a role in different pathologies associated with cognitive impairment, such as vascular dementia (VD) or Alzheimer's disease (AD). The aim of this review is to summarize, within the peripheral immune system, the imp...
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| Veröffentlicht in: | British journal of pharmacology 2024-03, Vol.181 (6), p.777-798 |
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| creator | García‐Culebras, Alicia Cuartero, María Isabel Peña‐Martínez, Carolina Moraga, Ana Vázquez‐Reyes, Sandra Castro‐Millán, Francisco Javier Cortes‐Canteli, Marta Lizasoain, Ignacio Moro, María Ángeles |
| description | Growing evidence supports the suggestion that the peripheral immune system plays a role in different pathologies associated with cognitive impairment, such as vascular dementia (VD) or Alzheimer's disease (AD). The aim of this review is to summarize, within the peripheral immune system, the implications of different types of myeloid cells in AD and VD, with a special focus on post‐stroke cognitive impairment and dementia (PSCID). We will review the contributions of the myeloid lineage, from peripheral cells (neutrophils, platelets, monocytes and monocyte‐derived macrophages) to central nervous system (CNS)‐associated cells (perivascular macrophages and microglia). Finally, we will evaluate different potential strategies for pharmacological modulation of pathological processes mediated by myeloid cell subsets, with an emphasis on neutrophils, their interaction with platelets and the process of immunothrombosis that triggers neutrophil‐dependent capillary stall and hypoperfusion, as possible effector mechanisms that may pave the way to novel therapeutic avenues to stop dementia, the epidemic of our time.
LINKED ARTICLES
This article is part of a themed issue From Alzheimer's Disease to Vascular Dementia: Different Roads Leading to Cognitive Decline. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.6/issuetoc |
| doi_str_mv | 10.1111/bph.16159 |
| format | Article |
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LINKED ARTICLES
This article is part of a themed issue From Alzheimer's Disease to Vascular Dementia: Different Roads Leading to Cognitive Decline. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.6/issuetoc</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/bph.16159</identifier><identifier>PMID: 37282844</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Alzheimer's disease ; Central nervous system ; Cognitive ability ; Dementia ; Dementia disorders ; Immune system ; Leukocytes (neutrophilic) ; Macrophages ; Microglia ; Monocytes ; Myeloid cells ; NETs ; Neurodegenerative diseases ; Neutrophils ; Platelets ; PSCID ; Sexually transmitted diseases ; STD ; Stroke ; Therapeutic targets ; Vascular dementia</subject><ispartof>British journal of pharmacology, 2024-03, Vol.181 (6), p.777-798</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.</rights><rights>2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-58a6e8ee047d706fbe2d951a71bddd688035b029860cd7bd03d8d7b6a6844a293</citedby><cites>FETCH-LOGICAL-c3889-58a6e8ee047d706fbe2d951a71bddd688035b029860cd7bd03d8d7b6a6844a293</cites><orcidid>0000-0003-1010-8237 ; 0000-0003-2362-0117 ; 0000-0003-4728-068X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbph.16159$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbph.16159$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37282844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García‐Culebras, Alicia</creatorcontrib><creatorcontrib>Cuartero, María Isabel</creatorcontrib><creatorcontrib>Peña‐Martínez, Carolina</creatorcontrib><creatorcontrib>Moraga, Ana</creatorcontrib><creatorcontrib>Vázquez‐Reyes, Sandra</creatorcontrib><creatorcontrib>Castro‐Millán, Francisco Javier</creatorcontrib><creatorcontrib>Cortes‐Canteli, Marta</creatorcontrib><creatorcontrib>Lizasoain, Ignacio</creatorcontrib><creatorcontrib>Moro, María Ángeles</creatorcontrib><title>Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Growing evidence supports the suggestion that the peripheral immune system plays a role in different pathologies associated with cognitive impairment, such as vascular dementia (VD) or Alzheimer's disease (AD). The aim of this review is to summarize, within the peripheral immune system, the implications of different types of myeloid cells in AD and VD, with a special focus on post‐stroke cognitive impairment and dementia (PSCID). We will review the contributions of the myeloid lineage, from peripheral cells (neutrophils, platelets, monocytes and monocyte‐derived macrophages) to central nervous system (CNS)‐associated cells (perivascular macrophages and microglia). Finally, we will evaluate different potential strategies for pharmacological modulation of pathological processes mediated by myeloid cell subsets, with an emphasis on neutrophils, their interaction with platelets and the process of immunothrombosis that triggers neutrophil‐dependent capillary stall and hypoperfusion, as possible effector mechanisms that may pave the way to novel therapeutic avenues to stop dementia, the epidemic of our time.
LINKED ARTICLES
This article is part of a themed issue From Alzheimer's Disease to Vascular Dementia: Different Roads Leading to Cognitive Decline. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.6/issuetoc</description><subject>Alzheimer's disease</subject><subject>Central nervous system</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Immune system</subject><subject>Leukocytes (neutrophilic)</subject><subject>Macrophages</subject><subject>Microglia</subject><subject>Monocytes</subject><subject>Myeloid cells</subject><subject>NETs</subject><subject>Neurodegenerative diseases</subject><subject>Neutrophils</subject><subject>Platelets</subject><subject>PSCID</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Stroke</subject><subject>Therapeutic targets</subject><subject>Vascular dementia</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kD1PwzAQhi0EoqUw8AeQJQZgSGvnw3FYUKmAIhXRAQYmy4mv1FW-sBNQ-fW4pDAgccsN9-jRvS9Cx5QMqZtRWi-HlNEo2UF9GsbMiwJOd1GfEBJ7lHLeQwfWrghxxzjaR70g9rnPw7CPXh7WkFda4Qzy3GJd4ndpszaXBisooGy0xLJUeJx_LkEXYM4sVtqCtHCJ55W1Os0BN0swsoa20RlupHmFxl4dor2FzC0cbfcAPd_ePE2m3uzx7n4ynnlZwHniRVwy4AAkjFVM2CIFXyURlTFNlVKMcxJEKfETzkim4lSRQHG3mWTuf-knwQCdd97aVG8t2EYU2m7SyBKq1gqXNAid0YkG6PQPuqpaU7rvhJ_4gU94QrmjLjoqMy6fgYWojS6kWQtKxKZv4foW33079mRrbNMC1C_5U7ADRh3woXNY_28S1_Npp_wCNZCI_g</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>García‐Culebras, Alicia</creator><creator>Cuartero, María Isabel</creator><creator>Peña‐Martínez, Carolina</creator><creator>Moraga, Ana</creator><creator>Vázquez‐Reyes, Sandra</creator><creator>Castro‐Millán, Francisco Javier</creator><creator>Cortes‐Canteli, Marta</creator><creator>Lizasoain, Ignacio</creator><creator>Moro, María Ángeles</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1010-8237</orcidid><orcidid>https://orcid.org/0000-0003-2362-0117</orcidid><orcidid>https://orcid.org/0000-0003-4728-068X</orcidid></search><sort><creationdate>202403</creationdate><title>Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?</title><author>García‐Culebras, Alicia ; Cuartero, María Isabel ; Peña‐Martínez, Carolina ; Moraga, Ana ; Vázquez‐Reyes, Sandra ; Castro‐Millán, Francisco Javier ; Cortes‐Canteli, Marta ; Lizasoain, Ignacio ; Moro, María Ángeles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-58a6e8ee047d706fbe2d951a71bddd688035b029860cd7bd03d8d7b6a6844a293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alzheimer's disease</topic><topic>Central nervous system</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Immune system</topic><topic>Leukocytes (neutrophilic)</topic><topic>Macrophages</topic><topic>Microglia</topic><topic>Monocytes</topic><topic>Myeloid cells</topic><topic>NETs</topic><topic>Neurodegenerative diseases</topic><topic>Neutrophils</topic><topic>Platelets</topic><topic>PSCID</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Stroke</topic><topic>Therapeutic targets</topic><topic>Vascular dementia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García‐Culebras, Alicia</creatorcontrib><creatorcontrib>Cuartero, María Isabel</creatorcontrib><creatorcontrib>Peña‐Martínez, Carolina</creatorcontrib><creatorcontrib>Moraga, Ana</creatorcontrib><creatorcontrib>Vázquez‐Reyes, Sandra</creatorcontrib><creatorcontrib>Castro‐Millán, Francisco Javier</creatorcontrib><creatorcontrib>Cortes‐Canteli, Marta</creatorcontrib><creatorcontrib>Lizasoain, Ignacio</creatorcontrib><creatorcontrib>Moro, María Ángeles</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García‐Culebras, Alicia</au><au>Cuartero, María Isabel</au><au>Peña‐Martínez, Carolina</au><au>Moraga, Ana</au><au>Vázquez‐Reyes, Sandra</au><au>Castro‐Millán, Francisco Javier</au><au>Cortes‐Canteli, Marta</au><au>Lizasoain, Ignacio</au><au>Moro, María Ángeles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2024-03</date><risdate>2024</risdate><volume>181</volume><issue>6</issue><spage>777</spage><epage>798</epage><pages>777-798</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>Growing evidence supports the suggestion that the peripheral immune system plays a role in different pathologies associated with cognitive impairment, such as vascular dementia (VD) or Alzheimer's disease (AD). The aim of this review is to summarize, within the peripheral immune system, the implications of different types of myeloid cells in AD and VD, with a special focus on post‐stroke cognitive impairment and dementia (PSCID). We will review the contributions of the myeloid lineage, from peripheral cells (neutrophils, platelets, monocytes and monocyte‐derived macrophages) to central nervous system (CNS)‐associated cells (perivascular macrophages and microglia). Finally, we will evaluate different potential strategies for pharmacological modulation of pathological processes mediated by myeloid cell subsets, with an emphasis on neutrophils, their interaction with platelets and the process of immunothrombosis that triggers neutrophil‐dependent capillary stall and hypoperfusion, as possible effector mechanisms that may pave the way to novel therapeutic avenues to stop dementia, the epidemic of our time.
LINKED ARTICLES
This article is part of a themed issue From Alzheimer's Disease to Vascular Dementia: Different Roads Leading to Cognitive Decline. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.6/issuetoc</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>37282844</pmid><doi>10.1111/bph.16159</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0003-1010-8237</orcidid><orcidid>https://orcid.org/0000-0003-2362-0117</orcidid><orcidid>https://orcid.org/0000-0003-4728-068X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Alzheimer's disease Central nervous system Cognitive ability Dementia Dementia disorders Immune system Leukocytes (neutrophilic) Macrophages Microglia Monocytes Myeloid cells NETs Neurodegenerative diseases Neutrophils Platelets PSCID Sexually transmitted diseases STD Stroke Therapeutic targets Vascular dementia |
| title | Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets? |
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