qTPI: A quasi-toxicity probability interval design for phase I trials with multiple-grade toxicities

The common terminology criteria for adverse events by the National Cancer Institute has greatly facilitated the revolution of drug development and an increasing number of Phase I trials have started to collect multiple-grade toxicity endpoints. Appropriate and yet transparent Phase I statistical des...

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Veröffentlicht in:	Statistical methods in medical research 2023-07, Vol.32 (7), p.1389-1402
Hauptverfasser:	Ling, Haodong, Shi, Haolun, Yuan, Nan, Ji, Yuan, Lin, Xiaolei
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayesian analysis Cancer Critical incidents Dosage Drug development Elicitation Probability Reliability Sarcoma Soft tissues Specification Statistical analysis Terminology Toxicity
Online-Zugang:	Volltext
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