What animal model should I use to study necrotizing enterocolitis?
Unfortunately, we are all too familiar with the statement: “Necrotizing enterocolitis remains the leading cause of gastrointestinal surgical emergency in preterm neonates”. It's been five decades since the first animal models of necrotizing enterocolitis (NEC) were described. There remains much...
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| Veröffentlicht in: | Seminars in pediatric surgery 2023-06, Vol.32 (3), p.151313-151313, Article 151313 |
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| container_title | Seminars in pediatric surgery |
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| creator | Won, Mitchell M. Mladenov, Georgi D. Raymond, Steven L. Khan, Faraz A. Radulescu, Andrei |
| description | Unfortunately, we are all too familiar with the statement: “Necrotizing enterocolitis remains the leading cause of gastrointestinal surgical emergency in preterm neonates”.
It's been five decades since the first animal models of necrotizing enterocolitis (NEC) were described. There remains much investigative work to be done on identifying various aspects of NEC, ranging from the underlying mechanisms to treatment modalities. Experimental NEC is mainly focused on a rat, mouse, and piglet models. Our aim is to not only highlight the pros and cons of these three main models, but to also present some of the less-used animal models that have contributed to the body of knowledge about NEC.
Choosing an appropriate model is essential to conducting effective research and answering the questions asked. As such, this paper reviews some of the variations that come with each model. |
| doi_str_mv | 10.1016/j.sempedsurg.2023.151313 |
| format | Article |
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It's been five decades since the first animal models of necrotizing enterocolitis (NEC) were described. There remains much investigative work to be done on identifying various aspects of NEC, ranging from the underlying mechanisms to treatment modalities. Experimental NEC is mainly focused on a rat, mouse, and piglet models. Our aim is to not only highlight the pros and cons of these three main models, but to also present some of the less-used animal models that have contributed to the body of knowledge about NEC.
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It's been five decades since the first animal models of necrotizing enterocolitis (NEC) were described. There remains much investigative work to be done on identifying various aspects of NEC, ranging from the underlying mechanisms to treatment modalities. Experimental NEC is mainly focused on a rat, mouse, and piglet models. Our aim is to not only highlight the pros and cons of these three main models, but to also present some of the less-used animal models that have contributed to the body of knowledge about NEC.
Choosing an appropriate model is essential to conducting effective research and answering the questions asked. As such, this paper reviews some of the variations that come with each model.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37276781</pmid><doi>10.1016/j.sempedsurg.2023.151313</doi><tpages>1</tpages></addata></record> |
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| ispartof | Seminars in pediatric surgery, 2023-06, Vol.32 (3), p.151313-151313, Article 151313 |
| issn | 1055-8586 1532-9453 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animal models Animals Disease Models, Animal Enterocolitis, Necrotizing - diagnosis Enterocolitis, Necrotizing - etiology Enterocolitis, Necrotizing - therapy Mice Mouse Necrotizing enterocolitis Rat Rats Swine |
| title | What animal model should I use to study necrotizing enterocolitis? |
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