IRAK-M Ablation Promotes Status Epilepticus-Induced Neuroinflammation via Activating M1 Microglia and Impairing Excitatory Synaptic Function

Epilepsy is one of the most common neurological disorders. The pro-epileptic and antiepileptic roles of microglia have recently garnered significant attention. Interleukin-1 receptor-associated kinase (IRAK)-M, an important kinase in the innate immune response, is mainly expressed in microglia and a...

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Veröffentlicht in:	Molecular neurobiology 2023-09, Vol.60 (9), p.5199-5213
Hauptverfasser:	Liang, Xiao-Shan, Qian, Ting-Lin, Xiong, Yi-Fan, Liang, Xiao-Tao, Ding, Yue-Wen, Zhu, Xiao-Yu, Li, Yun-Lv, Zhou, Jie-Li, Tan, Le-Yi, Li, Wei-Peng, Xie, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell activation Cell Biology Epilepsy Excitotoxicity Flow cytometry Gene expression Glial cells Glutamatergic transmission Glutamic acid receptors Hippocampus Immune response Immunofluorescence Inflammation Interleukin 1 Kinases Microglia mRNA N-Methyl-D-aspartic acid receptors Neurobiology Neurological diseases Neurology Neuronal-glial interactions Neurosciences Phenotypes Pilocarpine Polarization Pyramidal cells Seizures Signal transduction Synaptic transmission
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