Prognostic impact of a reduction in the fibrosis-4 index among patients hospitalized with acute heart failure
Although the fibrosis-4 index (FIB-4) is associated with right atrial pressure or prognosis in acute heart failure (AHF), the prognostic impact of its reduction during hospitalization remains uncertain. We included 877 patients (age, 74.9 ± 12.0 years; 58% male) hospitalized with AHF. The reduction...
Gespeichert in:
| Veröffentlicht in: | Heart and vessels 2023-10, Vol.38 (10), p.1235-1243 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1243 |
|---|---|
| container_issue | 10 |
| container_start_page | 1235 |
| container_title | Heart and vessels |
| container_volume | 38 |
| creator | Maeda, Daichi Kanzaki, Yumiko Sakane, Kazushi Tsuda, Kosuke Akamatsu, Kanako Hourai, Ryoto Okuno, Takahiro Tokura, Daisuke Hasegawa, Hitomi T. Morita, Hideaki Ito, Takahide Hoshiga, Masaaki |
| description | Although the fibrosis-4 index (FIB-4) is associated with right atrial pressure or prognosis in acute heart failure (AHF), the prognostic impact of its reduction during hospitalization remains uncertain. We included 877 patients (age, 74.9 ± 12.0 years; 58% male) hospitalized with AHF. The reduction in FIB-4 was defined as: (FIB-4 on admission–FIB-4 at discharge)/FIB-4 on admission × 100. Patients were divided into low ( 27.4%, n = 292) FIB-4 reduction groups. The primary outcome was a composite of all-cause death or heart failure rehospitalization within 180 days. The median FIB-4 reduction was 14.7% (interquartile range − 7.8–34.9%). The primary outcome was observed in 79 (27.0%), 63 (21.6%), and 41 (14.0%) patients in the low, middle, and high FIB-4 reduction groups, respectively (P = 0.001). Adjusted Cox proportional-hazards analysis revealed that the middle and low FIB-4 reduction groups were associated with the primary outcome, independent of the pre-existing risk model including baseline FIB-4 ([high vs. middle] hazard ratio [HR]: 1.70, 95% confidence interval [CI]: 1.10–2,63, P = 0.017; [high vs. low] HR: 2.16, 95% CI 1.41–3.32, P |
| doi_str_mv | 10.1007/s00380-023-02273-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2823040162</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2823040162</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-d86f317ccea8a84beb516c876e2afd649c5f68035bec7cce1dd84c4b8477ef93</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhi1UBFvgD3BAlrj0kuKPxHaOFaIfEhIc9m45znjXqyQOtqPS_nq8LLRSDz2MRpp55p3RvAhdUvKZEiJvEiFckYowXoJJXokjtKKCNhVrJP-AVqSlpFKcyVP0MaUdIbRpaXuCTrlkUjZCrdD4GMNmCil7i_04G5txcNjgCP1isw8T9hPOW8DOdzEkn6q6VHp4xmYM0wbPJnuYcsLbkGafzeB_Q49_-rzFxi4Z8BZMzNgZPywRztGxM0OCi7d8htZf79a336v7h28_br_cV5a3ba56JRyn0lowyqi6g66hwiopgBnXi7q1jROK8KYDu6do36va1p2qpQTX8jP06SA7x_C0QMp69MnCMJgJwpI0U4yTmlDBCnr9D7oLS5zKcYVqlBCSClEodqBs-UGK4PQc_WjiL02J3nuhD17o4oV-9ULvh67epJduhP7PyPvzC8APQCqtaQPx7-7_yL4AHQOV_Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2858667166</pqid></control><display><type>article</type><title>Prognostic impact of a reduction in the fibrosis-4 index among patients hospitalized with acute heart failure</title><source>Springer Nature - Complete Springer Journals</source><creator>Maeda, Daichi ; Kanzaki, Yumiko ; Sakane, Kazushi ; Tsuda, Kosuke ; Akamatsu, Kanako ; Hourai, Ryoto ; Okuno, Takahiro ; Tokura, Daisuke ; Hasegawa, Hitomi T. ; Morita, Hideaki ; Ito, Takahide ; Hoshiga, Masaaki</creator><creatorcontrib>Maeda, Daichi ; Kanzaki, Yumiko ; Sakane, Kazushi ; Tsuda, Kosuke ; Akamatsu, Kanako ; Hourai, Ryoto ; Okuno, Takahiro ; Tokura, Daisuke ; Hasegawa, Hitomi T. ; Morita, Hideaki ; Ito, Takahide ; Hoshiga, Masaaki</creatorcontrib><description>Although the fibrosis-4 index (FIB-4) is associated with right atrial pressure or prognosis in acute heart failure (AHF), the prognostic impact of its reduction during hospitalization remains uncertain. We included 877 patients (age, 74.9 ± 12.0 years; 58% male) hospitalized with AHF. The reduction in FIB-4 was defined as: (FIB-4 on admission–FIB-4 at discharge)/FIB-4 on admission × 100. Patients were divided into low (< 1.0%, n = 293), middle (1.0–27.4%, n = 292), and high (> 27.4%, n = 292) FIB-4 reduction groups. The primary outcome was a composite of all-cause death or heart failure rehospitalization within 180 days. The median FIB-4 reduction was 14.7% (interquartile range − 7.8–34.9%). The primary outcome was observed in 79 (27.0%), 63 (21.6%), and 41 (14.0%) patients in the low, middle, and high FIB-4 reduction groups, respectively (P = 0.001). Adjusted Cox proportional-hazards analysis revealed that the middle and low FIB-4 reduction groups were associated with the primary outcome, independent of the pre-existing risk model including baseline FIB-4 ([high vs. middle] hazard ratio [HR]: 1.70, 95% confidence interval [CI]: 1.10–2,63, P = 0.017; [high vs. low] HR: 2.16, 95% CI 1.41–3.32, P < 0.001). FIB-4 reduction provided additional prognostic value to the baseline model, including well-known prognostic factors ([continuous net reclassification improvement] 0.304; 95% CI 0.139–0.464; P < 0.001; [integrated discrimination improvement] 0.011; 95% CI 0.004–0.017; P = 0.001). Additionally, the combination of the reduction in FIB-4 and brain natriuretic peptide was useful for risk stratification. In conclusion, among patients hospitalized with AHF, a greater FIB-4 reduction during hospitalization was associated with better prognoses.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-023-02273-6</identifier><identifier>PMID: 37277568</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Biomedical Engineering and Bioengineering ; Brain natriuretic peptide ; Cardiac Surgery ; Cardiology ; Confidence intervals ; Congestive heart failure ; Fibrosis ; Heart failure ; Hospitalization ; Medical prognosis ; Medicine ; Medicine & Public Health ; Original Article ; Prognosis ; Reclassification ; Reduction ; Vascular Surgery</subject><ispartof>Heart and vessels, 2023-10, Vol.38 (10), p.1235-1243</ispartof><rights>Springer Nature Japan KK, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Springer Nature Japan KK, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-d86f317ccea8a84beb516c876e2afd649c5f68035bec7cce1dd84c4b8477ef93</citedby><cites>FETCH-LOGICAL-c399t-d86f317ccea8a84beb516c876e2afd649c5f68035bec7cce1dd84c4b8477ef93</cites><orcidid>0000-0001-5438-3500</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-023-02273-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-023-02273-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37277568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maeda, Daichi</creatorcontrib><creatorcontrib>Kanzaki, Yumiko</creatorcontrib><creatorcontrib>Sakane, Kazushi</creatorcontrib><creatorcontrib>Tsuda, Kosuke</creatorcontrib><creatorcontrib>Akamatsu, Kanako</creatorcontrib><creatorcontrib>Hourai, Ryoto</creatorcontrib><creatorcontrib>Okuno, Takahiro</creatorcontrib><creatorcontrib>Tokura, Daisuke</creatorcontrib><creatorcontrib>Hasegawa, Hitomi T.</creatorcontrib><creatorcontrib>Morita, Hideaki</creatorcontrib><creatorcontrib>Ito, Takahide</creatorcontrib><creatorcontrib>Hoshiga, Masaaki</creatorcontrib><title>Prognostic impact of a reduction in the fibrosis-4 index among patients hospitalized with acute heart failure</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>Although the fibrosis-4 index (FIB-4) is associated with right atrial pressure or prognosis in acute heart failure (AHF), the prognostic impact of its reduction during hospitalization remains uncertain. We included 877 patients (age, 74.9 ± 12.0 years; 58% male) hospitalized with AHF. The reduction in FIB-4 was defined as: (FIB-4 on admission–FIB-4 at discharge)/FIB-4 on admission × 100. Patients were divided into low (< 1.0%, n = 293), middle (1.0–27.4%, n = 292), and high (> 27.4%, n = 292) FIB-4 reduction groups. The primary outcome was a composite of all-cause death or heart failure rehospitalization within 180 days. The median FIB-4 reduction was 14.7% (interquartile range − 7.8–34.9%). The primary outcome was observed in 79 (27.0%), 63 (21.6%), and 41 (14.0%) patients in the low, middle, and high FIB-4 reduction groups, respectively (P = 0.001). Adjusted Cox proportional-hazards analysis revealed that the middle and low FIB-4 reduction groups were associated with the primary outcome, independent of the pre-existing risk model including baseline FIB-4 ([high vs. middle] hazard ratio [HR]: 1.70, 95% confidence interval [CI]: 1.10–2,63, P = 0.017; [high vs. low] HR: 2.16, 95% CI 1.41–3.32, P < 0.001). FIB-4 reduction provided additional prognostic value to the baseline model, including well-known prognostic factors ([continuous net reclassification improvement] 0.304; 95% CI 0.139–0.464; P < 0.001; [integrated discrimination improvement] 0.011; 95% CI 0.004–0.017; P = 0.001). Additionally, the combination of the reduction in FIB-4 and brain natriuretic peptide was useful for risk stratification. In conclusion, among patients hospitalized with AHF, a greater FIB-4 reduction during hospitalization was associated with better prognoses.</description><subject>Biomedical Engineering and Bioengineering</subject><subject>Brain natriuretic peptide</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Confidence intervals</subject><subject>Congestive heart failure</subject><subject>Fibrosis</subject><subject>Heart failure</subject><subject>Hospitalization</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Reclassification</subject><subject>Reduction</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kU1P3DAQhi1UBFvgD3BAlrj0kuKPxHaOFaIfEhIc9m45znjXqyQOtqPS_nq8LLRSDz2MRpp55p3RvAhdUvKZEiJvEiFckYowXoJJXokjtKKCNhVrJP-AVqSlpFKcyVP0MaUdIbRpaXuCTrlkUjZCrdD4GMNmCil7i_04G5txcNjgCP1isw8T9hPOW8DOdzEkn6q6VHp4xmYM0wbPJnuYcsLbkGafzeB_Q49_-rzFxi4Z8BZMzNgZPywRztGxM0OCi7d8htZf79a336v7h28_br_cV5a3ba56JRyn0lowyqi6g66hwiopgBnXi7q1jROK8KYDu6do36va1p2qpQTX8jP06SA7x_C0QMp69MnCMJgJwpI0U4yTmlDBCnr9D7oLS5zKcYVqlBCSClEodqBs-UGK4PQc_WjiL02J3nuhD17o4oV-9ULvh67epJduhP7PyPvzC8APQCqtaQPx7-7_yL4AHQOV_Q</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Maeda, Daichi</creator><creator>Kanzaki, Yumiko</creator><creator>Sakane, Kazushi</creator><creator>Tsuda, Kosuke</creator><creator>Akamatsu, Kanako</creator><creator>Hourai, Ryoto</creator><creator>Okuno, Takahiro</creator><creator>Tokura, Daisuke</creator><creator>Hasegawa, Hitomi T.</creator><creator>Morita, Hideaki</creator><creator>Ito, Takahide</creator><creator>Hoshiga, Masaaki</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5438-3500</orcidid></search><sort><creationdate>20231001</creationdate><title>Prognostic impact of a reduction in the fibrosis-4 index among patients hospitalized with acute heart failure</title><author>Maeda, Daichi ; Kanzaki, Yumiko ; Sakane, Kazushi ; Tsuda, Kosuke ; Akamatsu, Kanako ; Hourai, Ryoto ; Okuno, Takahiro ; Tokura, Daisuke ; Hasegawa, Hitomi T. ; Morita, Hideaki ; Ito, Takahide ; Hoshiga, Masaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-d86f317ccea8a84beb516c876e2afd649c5f68035bec7cce1dd84c4b8477ef93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomedical Engineering and Bioengineering</topic><topic>Brain natriuretic peptide</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Confidence intervals</topic><topic>Congestive heart failure</topic><topic>Fibrosis</topic><topic>Heart failure</topic><topic>Hospitalization</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Reclassification</topic><topic>Reduction</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maeda, Daichi</creatorcontrib><creatorcontrib>Kanzaki, Yumiko</creatorcontrib><creatorcontrib>Sakane, Kazushi</creatorcontrib><creatorcontrib>Tsuda, Kosuke</creatorcontrib><creatorcontrib>Akamatsu, Kanako</creatorcontrib><creatorcontrib>Hourai, Ryoto</creatorcontrib><creatorcontrib>Okuno, Takahiro</creatorcontrib><creatorcontrib>Tokura, Daisuke</creatorcontrib><creatorcontrib>Hasegawa, Hitomi T.</creatorcontrib><creatorcontrib>Morita, Hideaki</creatorcontrib><creatorcontrib>Ito, Takahide</creatorcontrib><creatorcontrib>Hoshiga, Masaaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maeda, Daichi</au><au>Kanzaki, Yumiko</au><au>Sakane, Kazushi</au><au>Tsuda, Kosuke</au><au>Akamatsu, Kanako</au><au>Hourai, Ryoto</au><au>Okuno, Takahiro</au><au>Tokura, Daisuke</au><au>Hasegawa, Hitomi T.</au><au>Morita, Hideaki</au><au>Ito, Takahide</au><au>Hoshiga, Masaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic impact of a reduction in the fibrosis-4 index among patients hospitalized with acute heart failure</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>38</volume><issue>10</issue><spage>1235</spage><epage>1243</epage><pages>1235-1243</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>Although the fibrosis-4 index (FIB-4) is associated with right atrial pressure or prognosis in acute heart failure (AHF), the prognostic impact of its reduction during hospitalization remains uncertain. We included 877 patients (age, 74.9 ± 12.0 years; 58% male) hospitalized with AHF. The reduction in FIB-4 was defined as: (FIB-4 on admission–FIB-4 at discharge)/FIB-4 on admission × 100. Patients were divided into low (< 1.0%, n = 293), middle (1.0–27.4%, n = 292), and high (> 27.4%, n = 292) FIB-4 reduction groups. The primary outcome was a composite of all-cause death or heart failure rehospitalization within 180 days. The median FIB-4 reduction was 14.7% (interquartile range − 7.8–34.9%). The primary outcome was observed in 79 (27.0%), 63 (21.6%), and 41 (14.0%) patients in the low, middle, and high FIB-4 reduction groups, respectively (P = 0.001). Adjusted Cox proportional-hazards analysis revealed that the middle and low FIB-4 reduction groups were associated with the primary outcome, independent of the pre-existing risk model including baseline FIB-4 ([high vs. middle] hazard ratio [HR]: 1.70, 95% confidence interval [CI]: 1.10–2,63, P = 0.017; [high vs. low] HR: 2.16, 95% CI 1.41–3.32, P < 0.001). FIB-4 reduction provided additional prognostic value to the baseline model, including well-known prognostic factors ([continuous net reclassification improvement] 0.304; 95% CI 0.139–0.464; P < 0.001; [integrated discrimination improvement] 0.011; 95% CI 0.004–0.017; P = 0.001). Additionally, the combination of the reduction in FIB-4 and brain natriuretic peptide was useful for risk stratification. In conclusion, among patients hospitalized with AHF, a greater FIB-4 reduction during hospitalization was associated with better prognoses.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>37277568</pmid><doi>10.1007/s00380-023-02273-6</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5438-3500</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0910-8327 |
| ispartof | Heart and vessels, 2023-10, Vol.38 (10), p.1235-1243 |
| issn | 0910-8327 1615-2573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2823040162 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Biomedical Engineering and Bioengineering Brain natriuretic peptide Cardiac Surgery Cardiology Confidence intervals Congestive heart failure Fibrosis Heart failure Hospitalization Medical prognosis Medicine Medicine & Public Health Original Article Prognosis Reclassification Reduction Vascular Surgery |
| title | Prognostic impact of a reduction in the fibrosis-4 index among patients hospitalized with acute heart failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T04%3A00%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20impact%20of%20a%20reduction%20in%20the%20fibrosis-4%20index%20among%20patients%20hospitalized%20with%20acute%20heart%20failure&rft.jtitle=Heart%20and%20vessels&rft.au=Maeda,%20Daichi&rft.date=2023-10-01&rft.volume=38&rft.issue=10&rft.spage=1235&rft.epage=1243&rft.pages=1235-1243&rft.issn=0910-8327&rft.eissn=1615-2573&rft_id=info:doi/10.1007/s00380-023-02273-6&rft_dat=%3Cproquest_cross%3E2823040162%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2858667166&rft_id=info:pmid/37277568&rfr_iscdi=true |