Comparison of caregiver burden between dementia with Lewy bodies and Alzheimer's disease
Background Caring for patients with dementia with Lewy bodies (DLB) would be more stressful for their caregivers than those with Alzheimer's disease (AD). In this study, we compared levels of caregiver burden and the possible influential factors on the caregiver burden between DLB and AD. Metho...
Gespeichert in:
| Veröffentlicht in: | Psychogeriatrics 2023-07, Vol.23 (4), p.682-689 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 689 |
|---|---|
| container_issue | 4 |
| container_start_page | 682 |
| container_title | Psychogeriatrics |
| container_volume | 23 |
| creator | Yuuki, Seiji Hashimoto, Mamoru Koyama, Asuka Matsushita, Masateru Ishikawa, Tomohisa Fukuhara, Ryuji Honda, Kazuki Miyagawa, Yusuke Ikeda, Manabu Takebayashi, Minoru |
| description | Background
Caring for patients with dementia with Lewy bodies (DLB) would be more stressful for their caregivers than those with Alzheimer's disease (AD). In this study, we compared levels of caregiver burden and the possible influential factors on the caregiver burden between DLB and AD.
Methods
Ninety‐three DLB patients and 500 AD patients were selected from the Kumamoto University Dementia Registry. Caregiver burden, neuropsychiatric symptoms, basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were assessed by the Japanese version of the Zarit Caregiver Burden Interview (J‐ZBI), the Neuropsychiatric Inventory (NPI), the Physical Self‐Maintenance Scale (PSMS), and the Lawton IADL scale, respectively.
Results
Despite the comparable Mini‐Mental State Examination score, the J‐ZBI score was significantly higher in the DLB group than the AD group (P = 0.012). A stepwise multiple regression analysis revealed that IADL score (β = −0.23, P = 0.049), PSMS score (β = −0.31, P = 0.010), disinhibition (β = 0.22, P = 0.008), and anxiety (β = 0.19, P = 0.027) were significantly associated with J‐ZBI score in DLB. In AD, caregiver's relationship with patient (child) (β = 0.104, P = 0.005), caregiver's gender (female) (β = 0.106, P = 0.004), IADL score (β = −0.237, P |
| doi_str_mv | 10.1111/psyg.12978 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2822709251</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2822709251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3818-143182efff2b0c399166e7777d812114083883f6117bd477dc4e2720a7d1d2983</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMovjf-AAm4UISpucl0klmW4gsKCiroashM7rSRedSkY6m_3tRRFy68m3O5fJx7OIQcARtAmIu5X00HwFOpNsguxDKNlGCwGXYRJ5EYMrZD9rx_ZYzHQyG2yY6QXAKHdJc8j9t6rp31bUPbkhba4dS-o6N55ww2NMfFEoMarLFZWE2XdjGjE1yuaN4ai57qxtBR9TFDW6M79dRYj9rjAdkqdeXx8Fv3ydPV5eP4JprcXd-OR5OoEApUBLEAxbEsS56zQqQpJAnKMEaFgBAzJZQSZQIgcxOHcxEjl5xpacDwVIl9ctb7zl371qFfZLX1BVaVbrDtfMYV55KlfAgBPfmDvrada0K6QAke_skv6rynCtd677DM5s7W2q0yYNm672zdd_bVd4CPvy27vEbzi_4UHADogaWtcPWPVXb_8HLdm34C3eKJLw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2832121751</pqid></control><display><type>article</type><title>Comparison of caregiver burden between dementia with Lewy bodies and Alzheimer's disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yuuki, Seiji ; Hashimoto, Mamoru ; Koyama, Asuka ; Matsushita, Masateru ; Ishikawa, Tomohisa ; Fukuhara, Ryuji ; Honda, Kazuki ; Miyagawa, Yusuke ; Ikeda, Manabu ; Takebayashi, Minoru</creator><creatorcontrib>Yuuki, Seiji ; Hashimoto, Mamoru ; Koyama, Asuka ; Matsushita, Masateru ; Ishikawa, Tomohisa ; Fukuhara, Ryuji ; Honda, Kazuki ; Miyagawa, Yusuke ; Ikeda, Manabu ; Takebayashi, Minoru</creatorcontrib><description>Background
Caring for patients with dementia with Lewy bodies (DLB) would be more stressful for their caregivers than those with Alzheimer's disease (AD). In this study, we compared levels of caregiver burden and the possible influential factors on the caregiver burden between DLB and AD.
Methods
Ninety‐three DLB patients and 500 AD patients were selected from the Kumamoto University Dementia Registry. Caregiver burden, neuropsychiatric symptoms, basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were assessed by the Japanese version of the Zarit Caregiver Burden Interview (J‐ZBI), the Neuropsychiatric Inventory (NPI), the Physical Self‐Maintenance Scale (PSMS), and the Lawton IADL scale, respectively.
Results
Despite the comparable Mini‐Mental State Examination score, the J‐ZBI score was significantly higher in the DLB group than the AD group (P = 0.012). A stepwise multiple regression analysis revealed that IADL score (β = −0.23, P = 0.049), PSMS score (β = −0.31, P = 0.010), disinhibition (β = 0.22, P = 0.008), and anxiety (β = 0.19, P = 0.027) were significantly associated with J‐ZBI score in DLB. In AD, caregiver's relationship with patient (child) (β = 0.104, P = 0.005), caregiver's gender (female) (β = 0.106, P = 0.004), IADL score (β = −0.237, P < 0.001), irritability (β = 0.183, P < 0.001), apathy (β = 0.132, P = 0.001), agitation (β = 0.118, P = 0.007), and aberrant motor behaviour (β = 0.107, P = 0.010) were associated with caregiver burden.
Conclusions
Caring for DLB patients caused a higher degree of caregiver burden than AD patients in the same level of cognitive decline. The factors responsible for the caregiver's burden were different between DLB and AD. The caregiver burden for DLB patients was associated with the disability of basic ADL, IADL impairment, anxiety and disinhibition.</description><identifier>ISSN: 1346-3500</identifier><identifier>EISSN: 1479-8301</identifier><identifier>DOI: 10.1111/psyg.12978</identifier><identifier>PMID: 37271219</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Activities of Daily Living ; ADL ; age care ; Alzheimer Disease - psychology ; Alzheimer's disease ; Anxiety ; Caregiver Burden ; Caregivers ; Caregivers - psychology ; Cognitive ability ; Dementia ; Dementia disorders ; dementia with Lewy bodies ; Emotional behavior ; Female ; Humans ; Lewy bodies ; Lewy Body Disease - psychology ; Multiple regression analysis ; Neurodegenerative diseases</subject><ispartof>Psychogeriatrics, 2023-07, Vol.23 (4), p.682-689</ispartof><rights>2023 Japanese Psychogeriatric Society.</rights><rights>Psychogeriatrics © 2023 Japanese Psychogeriatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3818-143182efff2b0c399166e7777d812114083883f6117bd477dc4e2720a7d1d2983</citedby><cites>FETCH-LOGICAL-c3818-143182efff2b0c399166e7777d812114083883f6117bd477dc4e2720a7d1d2983</cites><orcidid>0000-0003-0925-7964</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpsyg.12978$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpsyg.12978$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37271219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuuki, Seiji</creatorcontrib><creatorcontrib>Hashimoto, Mamoru</creatorcontrib><creatorcontrib>Koyama, Asuka</creatorcontrib><creatorcontrib>Matsushita, Masateru</creatorcontrib><creatorcontrib>Ishikawa, Tomohisa</creatorcontrib><creatorcontrib>Fukuhara, Ryuji</creatorcontrib><creatorcontrib>Honda, Kazuki</creatorcontrib><creatorcontrib>Miyagawa, Yusuke</creatorcontrib><creatorcontrib>Ikeda, Manabu</creatorcontrib><creatorcontrib>Takebayashi, Minoru</creatorcontrib><title>Comparison of caregiver burden between dementia with Lewy bodies and Alzheimer's disease</title><title>Psychogeriatrics</title><addtitle>Psychogeriatrics</addtitle><description>Background
Caring for patients with dementia with Lewy bodies (DLB) would be more stressful for their caregivers than those with Alzheimer's disease (AD). In this study, we compared levels of caregiver burden and the possible influential factors on the caregiver burden between DLB and AD.
Methods
Ninety‐three DLB patients and 500 AD patients were selected from the Kumamoto University Dementia Registry. Caregiver burden, neuropsychiatric symptoms, basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were assessed by the Japanese version of the Zarit Caregiver Burden Interview (J‐ZBI), the Neuropsychiatric Inventory (NPI), the Physical Self‐Maintenance Scale (PSMS), and the Lawton IADL scale, respectively.
Results
Despite the comparable Mini‐Mental State Examination score, the J‐ZBI score was significantly higher in the DLB group than the AD group (P = 0.012). A stepwise multiple regression analysis revealed that IADL score (β = −0.23, P = 0.049), PSMS score (β = −0.31, P = 0.010), disinhibition (β = 0.22, P = 0.008), and anxiety (β = 0.19, P = 0.027) were significantly associated with J‐ZBI score in DLB. In AD, caregiver's relationship with patient (child) (β = 0.104, P = 0.005), caregiver's gender (female) (β = 0.106, P = 0.004), IADL score (β = −0.237, P < 0.001), irritability (β = 0.183, P < 0.001), apathy (β = 0.132, P = 0.001), agitation (β = 0.118, P = 0.007), and aberrant motor behaviour (β = 0.107, P = 0.010) were associated with caregiver burden.
Conclusions
Caring for DLB patients caused a higher degree of caregiver burden than AD patients in the same level of cognitive decline. The factors responsible for the caregiver's burden were different between DLB and AD. The caregiver burden for DLB patients was associated with the disability of basic ADL, IADL impairment, anxiety and disinhibition.</description><subject>Activities of Daily Living</subject><subject>ADL</subject><subject>age care</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Anxiety</subject><subject>Caregiver Burden</subject><subject>Caregivers</subject><subject>Caregivers - psychology</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>dementia with Lewy bodies</subject><subject>Emotional behavior</subject><subject>Female</subject><subject>Humans</subject><subject>Lewy bodies</subject><subject>Lewy Body Disease - psychology</subject><subject>Multiple regression analysis</subject><subject>Neurodegenerative diseases</subject><issn>1346-3500</issn><issn>1479-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMovjf-AAm4UISpucl0klmW4gsKCiroashM7rSRedSkY6m_3tRRFy68m3O5fJx7OIQcARtAmIu5X00HwFOpNsguxDKNlGCwGXYRJ5EYMrZD9rx_ZYzHQyG2yY6QXAKHdJc8j9t6rp31bUPbkhba4dS-o6N55ww2NMfFEoMarLFZWE2XdjGjE1yuaN4ai57qxtBR9TFDW6M79dRYj9rjAdkqdeXx8Fv3ydPV5eP4JprcXd-OR5OoEApUBLEAxbEsS56zQqQpJAnKMEaFgBAzJZQSZQIgcxOHcxEjl5xpacDwVIl9ctb7zl371qFfZLX1BVaVbrDtfMYV55KlfAgBPfmDvrada0K6QAke_skv6rynCtd677DM5s7W2q0yYNm672zdd_bVd4CPvy27vEbzi_4UHADogaWtcPWPVXb_8HLdm34C3eKJLw</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Yuuki, Seiji</creator><creator>Hashimoto, Mamoru</creator><creator>Koyama, Asuka</creator><creator>Matsushita, Masateru</creator><creator>Ishikawa, Tomohisa</creator><creator>Fukuhara, Ryuji</creator><creator>Honda, Kazuki</creator><creator>Miyagawa, Yusuke</creator><creator>Ikeda, Manabu</creator><creator>Takebayashi, Minoru</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0925-7964</orcidid></search><sort><creationdate>202307</creationdate><title>Comparison of caregiver burden between dementia with Lewy bodies and Alzheimer's disease</title><author>Yuuki, Seiji ; Hashimoto, Mamoru ; Koyama, Asuka ; Matsushita, Masateru ; Ishikawa, Tomohisa ; Fukuhara, Ryuji ; Honda, Kazuki ; Miyagawa, Yusuke ; Ikeda, Manabu ; Takebayashi, Minoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3818-143182efff2b0c399166e7777d812114083883f6117bd477dc4e2720a7d1d2983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Activities of Daily Living</topic><topic>ADL</topic><topic>age care</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Anxiety</topic><topic>Caregiver Burden</topic><topic>Caregivers</topic><topic>Caregivers - psychology</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>dementia with Lewy bodies</topic><topic>Emotional behavior</topic><topic>Female</topic><topic>Humans</topic><topic>Lewy bodies</topic><topic>Lewy Body Disease - psychology</topic><topic>Multiple regression analysis</topic><topic>Neurodegenerative diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuuki, Seiji</creatorcontrib><creatorcontrib>Hashimoto, Mamoru</creatorcontrib><creatorcontrib>Koyama, Asuka</creatorcontrib><creatorcontrib>Matsushita, Masateru</creatorcontrib><creatorcontrib>Ishikawa, Tomohisa</creatorcontrib><creatorcontrib>Fukuhara, Ryuji</creatorcontrib><creatorcontrib>Honda, Kazuki</creatorcontrib><creatorcontrib>Miyagawa, Yusuke</creatorcontrib><creatorcontrib>Ikeda, Manabu</creatorcontrib><creatorcontrib>Takebayashi, Minoru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Psychogeriatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuuki, Seiji</au><au>Hashimoto, Mamoru</au><au>Koyama, Asuka</au><au>Matsushita, Masateru</au><au>Ishikawa, Tomohisa</au><au>Fukuhara, Ryuji</au><au>Honda, Kazuki</au><au>Miyagawa, Yusuke</au><au>Ikeda, Manabu</au><au>Takebayashi, Minoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of caregiver burden between dementia with Lewy bodies and Alzheimer's disease</atitle><jtitle>Psychogeriatrics</jtitle><addtitle>Psychogeriatrics</addtitle><date>2023-07</date><risdate>2023</risdate><volume>23</volume><issue>4</issue><spage>682</spage><epage>689</epage><pages>682-689</pages><issn>1346-3500</issn><eissn>1479-8301</eissn><abstract>Background
Caring for patients with dementia with Lewy bodies (DLB) would be more stressful for their caregivers than those with Alzheimer's disease (AD). In this study, we compared levels of caregiver burden and the possible influential factors on the caregiver burden between DLB and AD.
Methods
Ninety‐three DLB patients and 500 AD patients were selected from the Kumamoto University Dementia Registry. Caregiver burden, neuropsychiatric symptoms, basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were assessed by the Japanese version of the Zarit Caregiver Burden Interview (J‐ZBI), the Neuropsychiatric Inventory (NPI), the Physical Self‐Maintenance Scale (PSMS), and the Lawton IADL scale, respectively.
Results
Despite the comparable Mini‐Mental State Examination score, the J‐ZBI score was significantly higher in the DLB group than the AD group (P = 0.012). A stepwise multiple regression analysis revealed that IADL score (β = −0.23, P = 0.049), PSMS score (β = −0.31, P = 0.010), disinhibition (β = 0.22, P = 0.008), and anxiety (β = 0.19, P = 0.027) were significantly associated with J‐ZBI score in DLB. In AD, caregiver's relationship with patient (child) (β = 0.104, P = 0.005), caregiver's gender (female) (β = 0.106, P = 0.004), IADL score (β = −0.237, P < 0.001), irritability (β = 0.183, P < 0.001), apathy (β = 0.132, P = 0.001), agitation (β = 0.118, P = 0.007), and aberrant motor behaviour (β = 0.107, P = 0.010) were associated with caregiver burden.
Conclusions
Caring for DLB patients caused a higher degree of caregiver burden than AD patients in the same level of cognitive decline. The factors responsible for the caregiver's burden were different between DLB and AD. The caregiver burden for DLB patients was associated with the disability of basic ADL, IADL impairment, anxiety and disinhibition.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>37271219</pmid><doi>10.1111/psyg.12978</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0925-7964</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1346-3500 |
| ispartof | Psychogeriatrics, 2023-07, Vol.23 (4), p.682-689 |
| issn | 1346-3500 1479-8301 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2822709251 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Activities of Daily Living ADL age care Alzheimer Disease - psychology Alzheimer's disease Anxiety Caregiver Burden Caregivers Caregivers - psychology Cognitive ability Dementia Dementia disorders dementia with Lewy bodies Emotional behavior Female Humans Lewy bodies Lewy Body Disease - psychology Multiple regression analysis Neurodegenerative diseases |
| title | Comparison of caregiver burden between dementia with Lewy bodies and Alzheimer's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T01%3A12%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20caregiver%20burden%20between%20dementia%20with%20Lewy%20bodies%20and%20Alzheimer's%20disease&rft.jtitle=Psychogeriatrics&rft.au=Yuuki,%20Seiji&rft.date=2023-07&rft.volume=23&rft.issue=4&rft.spage=682&rft.epage=689&rft.pages=682-689&rft.issn=1346-3500&rft.eissn=1479-8301&rft_id=info:doi/10.1111/psyg.12978&rft_dat=%3Cproquest_cross%3E2822709251%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2832121751&rft_id=info:pmid/37271219&rfr_iscdi=true |