Preoperative Treatment of Locally Advanced Rectal Cancer
In a trial comparing preoperative chemoradiotherapy and FOLFOX in patients with rectal cancer undergoing sphincter-sparing surgery, 5-year disease-free survival was 80.8% with FOLFOX and 78.6% with chemoradiotherapy.
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| Veröffentlicht in: | The New England journal of medicine 2023-07, Vol.389 (4), p.322-334 |
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| container_title | The New England journal of medicine |
| container_volume | 389 |
| creator | Schrag, Deborah Shi, Qian Weiser, Martin R. Gollub, Marc J. Saltz, Leonard B. Musher, Benjamin L. Goldberg, Joel Al Baghdadi, Tareq Goodman, Karyn A. McWilliams, Robert R. Farma, Jeffrey M. George, Thomas J. Kennecke, Hagen F. Shergill, Ardaman Montemurro, Michael Nelson, Garth D. Colgrove, Brian Gordon, Vallerie Venook, Alan P. O’Reilly, Eileen M. Meyerhardt, Jeffrey A. Dueck, Amylou C. Basch, Ethan Chang, George J. Mamon, Harvey J. |
| description | In a trial comparing preoperative chemoradiotherapy and FOLFOX in patients with rectal cancer undergoing sphincter-sparing surgery, 5-year disease-free survival was 80.8% with FOLFOX and 78.6% with chemoradiotherapy. |
| doi_str_mv | 10.1056/NEJMoa2303269 |
| format | Article |
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All rights reserved.</rights><rights>Copyright © 2023 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-b97cd69e77f7bab9978c0876e02234b86356a8e3e92b1621e182cc14b6653a483</citedby><cites>FETCH-LOGICAL-c390t-b97cd69e77f7bab9978c0876e02234b86356a8e3e92b1621e182cc14b6653a483</cites><orcidid>0000-0002-4334-5717 ; 0000-0003-3813-9318 ; 0000-0002-6249-9180 ; 0000-0002-8076-9199 ; 0000-0002-9912-1085</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2303269$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2303269$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37272534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schrag, Deborah</creatorcontrib><creatorcontrib>Shi, Qian</creatorcontrib><creatorcontrib>Weiser, Martin R.</creatorcontrib><creatorcontrib>Gollub, Marc J.</creatorcontrib><creatorcontrib>Saltz, Leonard B.</creatorcontrib><creatorcontrib>Musher, Benjamin L.</creatorcontrib><creatorcontrib>Goldberg, Joel</creatorcontrib><creatorcontrib>Al Baghdadi, Tareq</creatorcontrib><creatorcontrib>Goodman, Karyn A.</creatorcontrib><creatorcontrib>McWilliams, Robert R.</creatorcontrib><creatorcontrib>Farma, Jeffrey M.</creatorcontrib><creatorcontrib>George, Thomas J.</creatorcontrib><creatorcontrib>Kennecke, Hagen F.</creatorcontrib><creatorcontrib>Shergill, Ardaman</creatorcontrib><creatorcontrib>Montemurro, Michael</creatorcontrib><creatorcontrib>Nelson, Garth D.</creatorcontrib><creatorcontrib>Colgrove, Brian</creatorcontrib><creatorcontrib>Gordon, Vallerie</creatorcontrib><creatorcontrib>Venook, Alan P.</creatorcontrib><creatorcontrib>O’Reilly, Eileen M.</creatorcontrib><creatorcontrib>Meyerhardt, Jeffrey A.</creatorcontrib><creatorcontrib>Dueck, Amylou C.</creatorcontrib><creatorcontrib>Basch, Ethan</creatorcontrib><creatorcontrib>Chang, George J.</creatorcontrib><creatorcontrib>Mamon, Harvey J.</creatorcontrib><title>Preoperative Treatment of Locally Advanced Rectal Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In a trial comparing preoperative chemoradiotherapy and FOLFOX in patients with rectal cancer undergoing sphincter-sparing surgery, 5-year disease-free survival was 80.8% with FOLFOX and 78.6% with chemoradiotherapy.</description><subject>5-Fluorouracil</subject><subject>Adult</subject><subject>Anal Canal - 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| subjects | 5-Fluorouracil Adult Anal Canal - surgery Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Cancer therapies Chemoradiotherapy Chemoradiotherapy - adverse effects Chemoradiotherapy - methods Chemotherapy Chemotherapy, Adjuvant Colorectal cancer Death Disease-Free Survival Fluorouracil - administration & dosage Fluorouracil - adverse effects Gastroenterology Gastrointestinal Tract Cancer Hematology Humans Leucovorin - administration & dosage Leucovorin - adverse effects Neoadjuvant Therapy Neoplasm Recurrence, Local - drug therapy Neoplasm Staging Oncology Organ Sparing Treatments Oxaliplatin Oxaliplatin - administration & dosage Oxaliplatin - adverse effects Pathology Patients Pelvis Preoperative Care Preoperative Period Radiation therapy Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - surgery Rectum Review boards Sphincter Statistical analysis Surgeons Surgery Survival Treatments in Oncology Tumors |
| title | Preoperative Treatment of Locally Advanced Rectal Cancer |
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