Up to an Hour of Donor Resuscitation Does Not Affect Pediatric Heart Transplantation Survival
In pediatric heart transplantation, surgeons historically avoided donors requiring cardiopulmonary resuscitation (CPR), despite evidence that donor CPR does not change posttransplant survival (PTS). This study sought to determine whether CPR duration affects PTS. All potential brain-dead donors aged
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| Veröffentlicht in: | The Annals of thoracic surgery 2024-03, Vol.117 (3), p.611-618 |
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| container_title | The Annals of thoracic surgery |
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| creator | Kulshrestha, Kevin Greenberg, Jason W. Guzman-Gomez, Amalia M. Kennedy, John T. Hossain, Md Monir Zhang, Yin Zafar, Farhan Morales, David L.S. |
| description | In pediatric heart transplantation, surgeons historically avoided donors requiring cardiopulmonary resuscitation (CPR), despite evidence that donor CPR does not change posttransplant survival (PTS). This study sought to determine whether CPR duration affects PTS.
All potential brain-dead donors aged |
| doi_str_mv | 10.1016/j.athoracsur.2023.04.043 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2822706096</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0003497523005696</els_id><sourcerecordid>2822706096</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-2823c29f949d859e789991d421d98ba04f3ec9ee93364d84140f276cd6c528663</originalsourceid><addsrcrecordid>eNqFkMtKAzEUhoMotlZfQbJ0MzW3uWRZ66VCUdF2KSHNnMGUdlKTTMG3N6VVl8KBkOQ7508-hDAlQ0pocb0c6vjhvDah80NGGB8SkYofoT7Nc5YVLJfHqE8I4ZmQZd5DZyEs05al61PU4yUrqRCsj97nGxwd1i2euM5j1-Bb1zqPXyF0wdioo3VtOoOAn1zEo6YBE_EL1FZHbw2egPYRz7xuw2al2wP_1vmt3erVOTpp9CrAxWEdoPn93Ww8yabPD4_j0TQznMqYsYpxw2QjhayrXEJZSSlpLRitZbXQRDQcjASQnBeirgQVpGFlYerC5KwqCj5AV_u5G-8-OwhRrW0wsEovAtcFlQJYSQoid2i1R413IXho1MbbtfZfihK1k6uW6k-u2slVRKTiqfXykNIt1lD_Nv7YTMDNHoD0160Fr5JCaE2y5ZM2VTv7f8o3WhePsw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2822706096</pqid></control><display><type>article</type><title>Up to an Hour of Donor Resuscitation Does Not Affect Pediatric Heart Transplantation Survival</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Kulshrestha, Kevin ; Greenberg, Jason W. ; Guzman-Gomez, Amalia M. ; Kennedy, John T. ; Hossain, Md Monir ; Zhang, Yin ; Zafar, Farhan ; Morales, David L.S.</creator><creatorcontrib>Kulshrestha, Kevin ; Greenberg, Jason W. ; Guzman-Gomez, Amalia M. ; Kennedy, John T. ; Hossain, Md Monir ; Zhang, Yin ; Zafar, Farhan ; Morales, David L.S.</creatorcontrib><description>In pediatric heart transplantation, surgeons historically avoided donors requiring cardiopulmonary resuscitation (CPR), despite evidence that donor CPR does not change posttransplant survival (PTS). This study sought to determine whether CPR duration affects PTS.
All potential brain-dead donors aged <40 years from 2001 to 2021 consented for heart procurement were identified in the United Network for Organ Sharing database (n = 54,671). Organ acceptance was compared by CPR administration and duration. All recipients aged <18 years with donor CPR data were then identified (n = 5680). Survival analyses were conducted using increasing CPR duration as a cut point to identify the shortest duration beyond which PTS worsened. Additional analyses were performed with multivariable and cubic spline regression.
Fifty-one percent of donors (28,012 of 54,671) received CPR. Donor acceptance was lower after CPR (54% vs 66%; P < .001) and across successive quartiles of CPR duration (P < .001). Of the transplant recipients, 48% (2753 of 5680) belonged to the no-CPR group, and 52% (2927 of 5680) belonged to the CPR group. Kaplan-Meier analyses of CPR duration attained significance at 55 minutes, after which PTS worsened (11.1 years vs 9.2 years; P = .025). There was no survival difference between the CPR ≤55 minutes group and the no-CPR group (11.1 years vs 11.2 years; P = .571). A cubic spline regression model confirmed that PTS worsened at more than 55 minutes of CPR. A Cox regression demonstrated that CPR >55 minutes predicted worsened PTS relative to no CPR (HR, 1.51; P = .007) but CPR ≤55 minutes did not (HR, 1.01; P = .864).
Donor CPR decreases organ acceptance for transplantation; however, shorter durations (≤55 minutes) had equivalent PTS when controlling for other risk factors.
[Display omitted]</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2023.04.043</identifier><identifier>PMID: 37271442</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Cardiopulmonary Resuscitation - adverse effects ; Child ; Graft Survival ; Heart Transplantation ; Humans ; Retrospective Studies ; Survival Analysis ; Time Factors ; Tissue Donors ; Treatment Outcome</subject><ispartof>The Annals of thoracic surgery, 2024-03, Vol.117 (3), p.611-618</ispartof><rights>2024 The Society of Thoracic Surgeons</rights><rights>Copyright © 2024 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c319t-2823c29f949d859e789991d421d98ba04f3ec9ee93364d84140f276cd6c528663</cites><orcidid>0000-0003-0657-1499</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.athoracsur.2023.04.043$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37271442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulshrestha, Kevin</creatorcontrib><creatorcontrib>Greenberg, Jason W.</creatorcontrib><creatorcontrib>Guzman-Gomez, Amalia M.</creatorcontrib><creatorcontrib>Kennedy, John T.</creatorcontrib><creatorcontrib>Hossain, Md Monir</creatorcontrib><creatorcontrib>Zhang, Yin</creatorcontrib><creatorcontrib>Zafar, Farhan</creatorcontrib><creatorcontrib>Morales, David L.S.</creatorcontrib><title>Up to an Hour of Donor Resuscitation Does Not Affect Pediatric Heart Transplantation Survival</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>In pediatric heart transplantation, surgeons historically avoided donors requiring cardiopulmonary resuscitation (CPR), despite evidence that donor CPR does not change posttransplant survival (PTS). This study sought to determine whether CPR duration affects PTS.
All potential brain-dead donors aged <40 years from 2001 to 2021 consented for heart procurement were identified in the United Network for Organ Sharing database (n = 54,671). Organ acceptance was compared by CPR administration and duration. All recipients aged <18 years with donor CPR data were then identified (n = 5680). Survival analyses were conducted using increasing CPR duration as a cut point to identify the shortest duration beyond which PTS worsened. Additional analyses were performed with multivariable and cubic spline regression.
Fifty-one percent of donors (28,012 of 54,671) received CPR. Donor acceptance was lower after CPR (54% vs 66%; P < .001) and across successive quartiles of CPR duration (P < .001). Of the transplant recipients, 48% (2753 of 5680) belonged to the no-CPR group, and 52% (2927 of 5680) belonged to the CPR group. Kaplan-Meier analyses of CPR duration attained significance at 55 minutes, after which PTS worsened (11.1 years vs 9.2 years; P = .025). There was no survival difference between the CPR ≤55 minutes group and the no-CPR group (11.1 years vs 11.2 years; P = .571). A cubic spline regression model confirmed that PTS worsened at more than 55 minutes of CPR. A Cox regression demonstrated that CPR >55 minutes predicted worsened PTS relative to no CPR (HR, 1.51; P = .007) but CPR ≤55 minutes did not (HR, 1.01; P = .864).
Donor CPR decreases organ acceptance for transplantation; however, shorter durations (≤55 minutes) had equivalent PTS when controlling for other risk factors.
[Display omitted]</description><subject>Cardiopulmonary Resuscitation - adverse effects</subject><subject>Child</subject><subject>Graft Survival</subject><subject>Heart Transplantation</subject><subject>Humans</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Tissue Donors</subject><subject>Treatment Outcome</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotlZfQbJ0MzW3uWRZ66VCUdF2KSHNnMGUdlKTTMG3N6VVl8KBkOQ7508-hDAlQ0pocb0c6vjhvDah80NGGB8SkYofoT7Nc5YVLJfHqE8I4ZmQZd5DZyEs05al61PU4yUrqRCsj97nGxwd1i2euM5j1-Bb1zqPXyF0wdioo3VtOoOAn1zEo6YBE_EL1FZHbw2egPYRz7xuw2al2wP_1vmt3erVOTpp9CrAxWEdoPn93Ww8yabPD4_j0TQznMqYsYpxw2QjhayrXEJZSSlpLRitZbXQRDQcjASQnBeirgQVpGFlYerC5KwqCj5AV_u5G-8-OwhRrW0wsEovAtcFlQJYSQoid2i1R413IXho1MbbtfZfihK1k6uW6k-u2slVRKTiqfXykNIt1lD_Nv7YTMDNHoD0160Fr5JCaE2y5ZM2VTv7f8o3WhePsw</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Kulshrestha, Kevin</creator><creator>Greenberg, Jason W.</creator><creator>Guzman-Gomez, Amalia M.</creator><creator>Kennedy, John T.</creator><creator>Hossain, Md Monir</creator><creator>Zhang, Yin</creator><creator>Zafar, Farhan</creator><creator>Morales, David L.S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0657-1499</orcidid></search><sort><creationdate>202403</creationdate><title>Up to an Hour of Donor Resuscitation Does Not Affect Pediatric Heart Transplantation Survival</title><author>Kulshrestha, Kevin ; Greenberg, Jason W. ; Guzman-Gomez, Amalia M. ; Kennedy, John T. ; Hossain, Md Monir ; Zhang, Yin ; Zafar, Farhan ; Morales, David L.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-2823c29f949d859e789991d421d98ba04f3ec9ee93364d84140f276cd6c528663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiopulmonary Resuscitation - adverse effects</topic><topic>Child</topic><topic>Graft Survival</topic><topic>Heart Transplantation</topic><topic>Humans</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><topic>Tissue Donors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulshrestha, Kevin</creatorcontrib><creatorcontrib>Greenberg, Jason W.</creatorcontrib><creatorcontrib>Guzman-Gomez, Amalia M.</creatorcontrib><creatorcontrib>Kennedy, John T.</creatorcontrib><creatorcontrib>Hossain, Md Monir</creatorcontrib><creatorcontrib>Zhang, Yin</creatorcontrib><creatorcontrib>Zafar, Farhan</creatorcontrib><creatorcontrib>Morales, David L.S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulshrestha, Kevin</au><au>Greenberg, Jason W.</au><au>Guzman-Gomez, Amalia M.</au><au>Kennedy, John T.</au><au>Hossain, Md Monir</au><au>Zhang, Yin</au><au>Zafar, Farhan</au><au>Morales, David L.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Up to an Hour of Donor Resuscitation Does Not Affect Pediatric Heart Transplantation Survival</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2024-03</date><risdate>2024</risdate><volume>117</volume><issue>3</issue><spage>611</spage><epage>618</epage><pages>611-618</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>In pediatric heart transplantation, surgeons historically avoided donors requiring cardiopulmonary resuscitation (CPR), despite evidence that donor CPR does not change posttransplant survival (PTS). This study sought to determine whether CPR duration affects PTS.
All potential brain-dead donors aged <40 years from 2001 to 2021 consented for heart procurement were identified in the United Network for Organ Sharing database (n = 54,671). Organ acceptance was compared by CPR administration and duration. All recipients aged <18 years with donor CPR data were then identified (n = 5680). Survival analyses were conducted using increasing CPR duration as a cut point to identify the shortest duration beyond which PTS worsened. Additional analyses were performed with multivariable and cubic spline regression.
Fifty-one percent of donors (28,012 of 54,671) received CPR. Donor acceptance was lower after CPR (54% vs 66%; P < .001) and across successive quartiles of CPR duration (P < .001). Of the transplant recipients, 48% (2753 of 5680) belonged to the no-CPR group, and 52% (2927 of 5680) belonged to the CPR group. Kaplan-Meier analyses of CPR duration attained significance at 55 minutes, after which PTS worsened (11.1 years vs 9.2 years; P = .025). There was no survival difference between the CPR ≤55 minutes group and the no-CPR group (11.1 years vs 11.2 years; P = .571). A cubic spline regression model confirmed that PTS worsened at more than 55 minutes of CPR. A Cox regression demonstrated that CPR >55 minutes predicted worsened PTS relative to no CPR (HR, 1.51; P = .007) but CPR ≤55 minutes did not (HR, 1.01; P = .864).
Donor CPR decreases organ acceptance for transplantation; however, shorter durations (≤55 minutes) had equivalent PTS when controlling for other risk factors.
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| subjects | Cardiopulmonary Resuscitation - adverse effects Child Graft Survival Heart Transplantation Humans Retrospective Studies Survival Analysis Time Factors Tissue Donors Treatment Outcome |
| title | Up to an Hour of Donor Resuscitation Does Not Affect Pediatric Heart Transplantation Survival |
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