Tubson-2 decoction ameliorates rheumatoid arthritis complicated with osteoporosis in CIA rats involving isochlorogenic acid A regulating IL-17/MAPK pathway

Osteoporosis (OP) is considered as one of the major comorbidities of rheumatoid arthritis (RA), and is responsible for fragility fracture. However, there is currently no effective treatment for RA complicated with OP. Tubson-2 decoction (TBD), a Mongolian medicine also known as Erwei Duzhong Decocti...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2023-07, Vol.116, p.154875-154875, Article 154875
Hauptverfasser:	Yang, Ya-Jun, Lu, Lu-Jiao, Wang, Jia-Jia, Ma, Shao-Yong, Xu, Bi-Lian, Lin, Rui, Chen, Qiu-Sheng, Ma, Zhi-Guo, Mo, Yu-Lin, Wang, Dong-Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - chemically induced Arthritis, Rheumatoid - drug therapy Cytokines - metabolism IL-17/MAPK pathway Interleukin-17 Isochlorogenic acid A Lipopolysaccharides - adverse effects Matrix Metalloproteinase 13 Molecular Docking Simulation Osteoporosis Osteoporosis - drug therapy Rats Rheumatoid arthritis Tubson-2 decoction Tumor Necrosis Factor-alpha
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