ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A

•The ADSCs treatment repaired the articular cartilage and maintained chondrocytes ECM homeostasis through modulating chondrocytes autophagy in OA.•This is the first report that ADSCs promoted cartilage repair through inhibiting the expression of miR-7-5p in OA.•ATG4A was defined as a target gene of...

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Veröffentlicht in:	International immunopharmacology 2023-07, Vol.120, p.110390-110390, Article 110390
Hauptverfasser:	Zhao, Shu, Liu, Yu'e, Wang, Jian, Wen, Yi, Wu, Baitong, Yang, Danjing, Wang, Guangming, Xiu, Guanghui, Ling, Bin, Du, Dajiang, Xu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	ADSCs Animals Apoptosis Autophagy cartilage repair Cartilage, Articular - metabolism Chondrocytes Mechanistic Target of Rapamycin Complex 1 - metabolism MicroRNAs - metabolism miR-7-5p Osteoarthritis Osteoarthritis - metabolism Rats
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