TRPV4 Regulates the Development of Psoriasis by Controlling Adenosine Triphosphate Expression in Keratinocytes and the Neuroimmune System

TRPV4 is a calcium ion channel that is widely expressed in various cells. It is also involved in physiological and pathological processes. However, the role of TRPV4 in psoriasis remains unknown. We aimed to investigate the role of TRPV4 in psoriasis using human psoriasis skin samples and an imiquim...

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Veröffentlicht in:	Journal of investigative dermatology 2023-12, Vol.143 (12), p.2356-2365.e5
Hauptverfasser:	Amalia, Syahla Nisaa, Baral, Hritu, Fujiwara, Chisako, Uchiyama, Akihiko, Inoue, Yuta, Yamazaki, Sahori, Ishikawa, Mai, Kosaka, Keiji, Sekiguchi, Akiko, Yokoyama, Yoko, Ogino, Sachiko, Torii, Ryoko, Hosoi, Mari, Shibasaki, Koji, Motegi, Sei-ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Dermatitis - pathology Disease Models, Animal Humans Imiquimod - pharmacology Keratinocytes - metabolism Mice Mice, Inbred BALB C Mice, Knockout Neuropeptides - metabolism Psoriasis - chemically induced Psoriasis - drug therapy Psoriasis - genetics Skin - metabolism TRPV Cation Channels - genetics TRPV Cation Channels - metabolism
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