Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo

A series of novel stilbene-based derivatives were designed and synthesized as tubulin/HDAC dual-target inhibitors. Among forty-three target compounds, compound II-19k not only exhibited considerable antiproliferative activity in the hematological cell line K562 with IC50 value of 0.003 μM, but also...

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Veröffentlicht in:	European journal of medicinal chemistry 2023-09, Vol.257, p.115529-115529, Article 115529
Hauptverfasser:	Zhu, Huajian, Zhu, Wenjian, Liu, Yang, Gao, Tian, Zhu, Jingjie, Tan, Yuchen, Hu, Han, Liang, Wenhao, Zhao, Lingyue, Chen, Jian, Zhu, Zheying, Chen, Jichao, Xu, Jinyi, Xu, Shengtao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor Dual-target inhibitors HDAC Stilbene Tubulin
Online-Zugang:	Volltext
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