Hyposterolactone A, a 3α‐Hydroxy Steroidal Lactone from the Deep‐Sea‐Derived Fungus Hypocrea sp. ZEN14

Hyposterolactone A, a 3α‐Hydroxy Steroidal Lactone from the Deep‐Sea‐Derived Fungus Hypocrea sp. ZEN14

Chemical investigation of the deep‐sea‐derived fungus Hypocrea sp. ZEN14 afforded a new 3α‐hydroxy steroidal lactone, hyposterolactone A (1) and 25 known secondary metabolites (2–26). The structure of the new compound was established by detailed spectroscopic analysis, electronic circular dichroism...

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Veröffentlicht in:Chemistry & biodiversity 2023-07, Vol.20 (7), p.e202300753-n/a
Hauptverfasser: Xu, Lin, Ma, Hua‐Bin, Wu, Taizong, Liu, Li‐Fang, Xie, Ming‐Min, Hu, Man‐Yi, Gai, Ying‐Bao, Zhong, Tian‐Hua, Yang, Xian‐Wen
Format: Artikel
Sprache:eng
Schlagworte:
Circular Dichroism
Cytotoxicity
deep-sea
Dichroism
ECD calculation
Fungi
fungus
Humans
Hypocrea
J-based configuration analysis
Lactones - pharmacology
Metabolites
Molecular Structure
Secondary metabolites
steroids
Steroids - pharmacology
Toxicity
Trichoderma
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Zusammenfassung:Chemical investigation of the deep‐sea‐derived fungus Hypocrea sp. ZEN14 afforded a new 3α‐hydroxy steroidal lactone, hyposterolactone A (1) and 25 known secondary metabolites (2–26). The structure of the new compound was established by detailed spectroscopic analysis, electronic circular dichroism (ECD) calculation as well as a J‐based configuration analysis. Compound 10 showed potent cytotoxicity against Huh7 and Jurkat cells with IC50 values of 1.4 μM and 6.7 μM, respectively.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300753