Oxymatrine Loaded Cross-Linked PVA Nanofibrous Scaffold: Design and Characterization and Anticancer Properties
This study focuses on the fabrication, characterization and anticancer properties of biocompatible and biodegradable composite nanofibers consisting of poly(vinyl alcohol) (PVA), oxymatrine (OM), and citric acid (CA) using a facile and high-yield centrifugal spinning process known as Forcespinning....
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| Veröffentlicht in: | Macromolecular bioscience 2023-10, Vol.23 (10), p.e2300098-e2300098 |
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| container_title | Macromolecular bioscience |
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| creator | Ahmed, Salahuddin Keniry, Megan Anaya-Barbosa, Narcedalia Padilla, Victoria Javed, Md Noushad Gilkerson, Robert Narula, Acharan S Ibrahim, Eman Lozano, Karen |
| description | This study focuses on the fabrication, characterization and anticancer properties of biocompatible and biodegradable composite nanofibers consisting of poly(vinyl alcohol) (PVA), oxymatrine (OM), and citric acid (CA) using a facile and high-yield centrifugal spinning process known as Forcespinning. The effects of varying concentrations of OM and CA on fiber diameter and molecular cross-linking are investigated. The morphological and thermo-physical properties, as well as water absorption of the developed nanofiber-based mats are characterized using microscopical analysis, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. In vitro anticancer studies are conducted with HCT116 colorectal cancer cells. Results show a high yield of long fibers embedded with beads. Fiber average diameters range between 462 and 528 nm depending on OM concentration. The thermal analysis results show that the fibers are stable at room temperature. The anticancer study reveals that PVA nanofiber membrane with high concentrations of OM can suppress the proliferation of HCT116 colorectal cancer cells. The study provides a comprehensive investigation of OM embedded into nanosized PVA fibers and the prospective application of these membranes as a drug delivery system. |
| doi_str_mv | 10.1002/mabi.202300098 |
| format | Article |
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The effects of varying concentrations of OM and CA on fiber diameter and molecular cross-linking are investigated. The morphological and thermo-physical properties, as well as water absorption of the developed nanofiber-based mats are characterized using microscopical analysis, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. In vitro anticancer studies are conducted with HCT116 colorectal cancer cells. Results show a high yield of long fibers embedded with beads. Fiber average diameters range between 462 and 528 nm depending on OM concentration. The thermal analysis results show that the fibers are stable at room temperature. The anticancer study reveals that PVA nanofiber membrane with high concentrations of OM can suppress the proliferation of HCT116 colorectal cancer cells. The study provides a comprehensive investigation of OM embedded into nanosized PVA fibers and the prospective application of these membranes as a drug delivery system.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.202300098</identifier><identifier>PMID: 37270675</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Anticancer properties ; Biocompatibility ; Biodegradation ; Calorimetry ; Cell proliferation ; Centrifugal force ; Citric acid ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - drug therapy ; Differential scanning calorimetry ; Drug delivery ; Drug delivery systems ; Fabrication ; Fibers ; Fourier transforms ; Humans ; Infrared analysis ; Infrared spectroscopy ; Long fibers ; Matrines ; Membranes ; Nanofibers ; Nanofibers - chemistry ; Physical properties ; Polyvinyl alcohol ; Polyvinyl Alcohol - chemistry ; Polyvinyl Alcohol - pharmacology ; Room temperature ; Spectroscopic analysis ; Spectrum analysis ; Thermal analysis ; Thermogravimetric analysis ; Tissue Scaffolds - chemistry ; Water absorption</subject><ispartof>Macromolecular bioscience, 2023-10, Vol.23 (10), p.e2300098-e2300098</ispartof><rights>2023 Wiley-VCH GmbH.</rights><rights>2023 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-ac37a4cbb1712ed5f72095594dd032643f2107f9d89bcfeb5bdc7ac792cf3e443</citedby><cites>FETCH-LOGICAL-c323t-ac37a4cbb1712ed5f72095594dd032643f2107f9d89bcfeb5bdc7ac792cf3e443</cites><orcidid>0000-0002-6676-8632 ; 0000-0002-0666-8496</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37270675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Salahuddin</creatorcontrib><creatorcontrib>Keniry, Megan</creatorcontrib><creatorcontrib>Anaya-Barbosa, Narcedalia</creatorcontrib><creatorcontrib>Padilla, Victoria</creatorcontrib><creatorcontrib>Javed, Md Noushad</creatorcontrib><creatorcontrib>Gilkerson, Robert</creatorcontrib><creatorcontrib>Narula, Acharan S</creatorcontrib><creatorcontrib>Ibrahim, Eman</creatorcontrib><creatorcontrib>Lozano, Karen</creatorcontrib><title>Oxymatrine Loaded Cross-Linked PVA Nanofibrous Scaffold: Design and Characterization and Anticancer Properties</title><title>Macromolecular bioscience</title><addtitle>Macromol Biosci</addtitle><description>This study focuses on the fabrication, characterization and anticancer properties of biocompatible and biodegradable composite nanofibers consisting of poly(vinyl alcohol) (PVA), oxymatrine (OM), and citric acid (CA) using a facile and high-yield centrifugal spinning process known as Forcespinning. The effects of varying concentrations of OM and CA on fiber diameter and molecular cross-linking are investigated. The morphological and thermo-physical properties, as well as water absorption of the developed nanofiber-based mats are characterized using microscopical analysis, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. In vitro anticancer studies are conducted with HCT116 colorectal cancer cells. Results show a high yield of long fibers embedded with beads. Fiber average diameters range between 462 and 528 nm depending on OM concentration. The thermal analysis results show that the fibers are stable at room temperature. The anticancer study reveals that PVA nanofiber membrane with high concentrations of OM can suppress the proliferation of HCT116 colorectal cancer cells. The study provides a comprehensive investigation of OM embedded into nanosized PVA fibers and the prospective application of these membranes as a drug delivery system.</description><subject>Anticancer properties</subject><subject>Biocompatibility</subject><subject>Biodegradation</subject><subject>Calorimetry</subject><subject>Cell proliferation</subject><subject>Centrifugal force</subject><subject>Citric acid</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Differential scanning calorimetry</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Fabrication</subject><subject>Fibers</subject><subject>Fourier transforms</subject><subject>Humans</subject><subject>Infrared analysis</subject><subject>Infrared spectroscopy</subject><subject>Long fibers</subject><subject>Matrines</subject><subject>Membranes</subject><subject>Nanofibers</subject><subject>Nanofibers - chemistry</subject><subject>Physical properties</subject><subject>Polyvinyl alcohol</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>Polyvinyl Alcohol - pharmacology</subject><subject>Room temperature</subject><subject>Spectroscopic analysis</subject><subject>Spectrum analysis</subject><subject>Thermal analysis</subject><subject>Thermogravimetric analysis</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Water absorption</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUlPwzAQhS0EolC4ckSRuHBJ8ZJkYm5VWaWKVmK5Ro4XcGnsYqcS5deTqqUHTrPom9HMewidETwgGNOrRtR2QDFlGGNe7qEjUpAizQnP93d5CT10HOMMYwIlp4eox4ACLiA_Qm7yvWpEG6zTydgLpVUyCj7GdGzdZ1dM34bJk3De2Dr4ZUyepTDGz9V1cqOjfXeJcN3EhwhCtjrYH9Fav2kOXWulcFKHZBr8QofW6niCDoyYR326jX30enf7MnpIx5P7x9FwnEpGWZsKyUBksq4JEKpVboBinuc8UwozWmTMUILBcFXyWhpd57WSICRwKg3TWcb66HKzdxH811LHtmpslHo-F053b1S0pJQVAMA79OIfOvPL4LrrOgqAFsCzsqMGG0qu1QnaVItgGxFWFcHV2olq7US1c6IbON-uXdaNVjv8T3r2C4cBhOI</recordid><startdate>202310</startdate><enddate>202310</enddate><creator>Ahmed, Salahuddin</creator><creator>Keniry, Megan</creator><creator>Anaya-Barbosa, Narcedalia</creator><creator>Padilla, Victoria</creator><creator>Javed, Md Noushad</creator><creator>Gilkerson, Robert</creator><creator>Narula, Acharan S</creator><creator>Ibrahim, Eman</creator><creator>Lozano, Karen</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6676-8632</orcidid><orcidid>https://orcid.org/0000-0002-0666-8496</orcidid></search><sort><creationdate>202310</creationdate><title>Oxymatrine Loaded Cross-Linked PVA Nanofibrous Scaffold: Design and Characterization and Anticancer Properties</title><author>Ahmed, Salahuddin ; Keniry, Megan ; Anaya-Barbosa, Narcedalia ; Padilla, Victoria ; Javed, Md Noushad ; Gilkerson, Robert ; Narula, Acharan S ; Ibrahim, Eman ; Lozano, Karen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-ac37a4cbb1712ed5f72095594dd032643f2107f9d89bcfeb5bdc7ac792cf3e443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anticancer properties</topic><topic>Biocompatibility</topic><topic>Biodegradation</topic><topic>Calorimetry</topic><topic>Cell proliferation</topic><topic>Centrifugal force</topic><topic>Citric acid</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Differential scanning calorimetry</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Fabrication</topic><topic>Fibers</topic><topic>Fourier transforms</topic><topic>Humans</topic><topic>Infrared analysis</topic><topic>Infrared spectroscopy</topic><topic>Long fibers</topic><topic>Matrines</topic><topic>Membranes</topic><topic>Nanofibers</topic><topic>Nanofibers - chemistry</topic><topic>Physical properties</topic><topic>Polyvinyl alcohol</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>Polyvinyl Alcohol - pharmacology</topic><topic>Room temperature</topic><topic>Spectroscopic analysis</topic><topic>Spectrum analysis</topic><topic>Thermal analysis</topic><topic>Thermogravimetric analysis</topic><topic>Tissue Scaffolds - chemistry</topic><topic>Water absorption</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Salahuddin</creatorcontrib><creatorcontrib>Keniry, Megan</creatorcontrib><creatorcontrib>Anaya-Barbosa, Narcedalia</creatorcontrib><creatorcontrib>Padilla, Victoria</creatorcontrib><creatorcontrib>Javed, Md Noushad</creatorcontrib><creatorcontrib>Gilkerson, Robert</creatorcontrib><creatorcontrib>Narula, Acharan S</creatorcontrib><creatorcontrib>Ibrahim, Eman</creatorcontrib><creatorcontrib>Lozano, Karen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Salahuddin</au><au>Keniry, Megan</au><au>Anaya-Barbosa, Narcedalia</au><au>Padilla, Victoria</au><au>Javed, Md Noushad</au><au>Gilkerson, Robert</au><au>Narula, Acharan S</au><au>Ibrahim, Eman</au><au>Lozano, Karen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxymatrine Loaded Cross-Linked PVA Nanofibrous Scaffold: Design and Characterization and Anticancer Properties</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol Biosci</addtitle><date>2023-10</date><risdate>2023</risdate><volume>23</volume><issue>10</issue><spage>e2300098</spage><epage>e2300098</epage><pages>e2300098-e2300098</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>This study focuses on the fabrication, characterization and anticancer properties of biocompatible and biodegradable composite nanofibers consisting of poly(vinyl alcohol) (PVA), oxymatrine (OM), and citric acid (CA) using a facile and high-yield centrifugal spinning process known as Forcespinning. The effects of varying concentrations of OM and CA on fiber diameter and molecular cross-linking are investigated. The morphological and thermo-physical properties, as well as water absorption of the developed nanofiber-based mats are characterized using microscopical analysis, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. In vitro anticancer studies are conducted with HCT116 colorectal cancer cells. Results show a high yield of long fibers embedded with beads. Fiber average diameters range between 462 and 528 nm depending on OM concentration. The thermal analysis results show that the fibers are stable at room temperature. The anticancer study reveals that PVA nanofiber membrane with high concentrations of OM can suppress the proliferation of HCT116 colorectal cancer cells. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anticancer properties Biocompatibility Biodegradation Calorimetry Cell proliferation Centrifugal force Citric acid Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Differential scanning calorimetry Drug delivery Drug delivery systems Fabrication Fibers Fourier transforms Humans Infrared analysis Infrared spectroscopy Long fibers Matrines Membranes Nanofibers Nanofibers - chemistry Physical properties Polyvinyl alcohol Polyvinyl Alcohol - chemistry Polyvinyl Alcohol - pharmacology Room temperature Spectroscopic analysis Spectrum analysis Thermal analysis Thermogravimetric analysis Tissue Scaffolds - chemistry Water absorption |
| title | Oxymatrine Loaded Cross-Linked PVA Nanofibrous Scaffold: Design and Characterization and Anticancer Properties |
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