Macromolecular crowding impact on anti-CRISPR AcrIIC3/NmeCas9 complex: Insights from scaled particle theory, molecular dynamics, and elastic networks models

The coupling of Cas9 and its inhibitor AcrIIC3, both from the bacterium Neisseria meningitidis (Nme), form a homodimer of the (NmeCas9/AcrIIC3)2 type. This coupling was studied to assess the impact of their interaction with the crowders in the following environments: (1) homogeneous crowded, (2) het...

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Veröffentlicht in:International journal of biological macromolecules 2023-07, Vol.244, p.125113-125113, Article 125113
Hauptverfasser: Delgado, Ariana, Vera-Villalobos, Joan, Paz, José Luis, Lossada, Carla, Hurtado-León, María Laura, Marrero-Ponce, Yovani, Toro-Mendoza, Jhoan, Alvarado, Ysaías J., González-Paz, Lenin
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Sprache:eng
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