Overexpression of Leishmania major protein arginine methyltransferase 6 reduces parasite infectivity in vivo

•L. major PRMT6 possesses all motifs characteristic of a functional type I PRMT.•LmjPRMT6 likely displays a narrow substrate specificity.•Overexpression of LmjPRMT6 reduces virulence in vivo. Arginine methylation is catalysed by Protein Arginine Methyltransferases (PRMTs) and can affect how a target...

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Veröffentlicht in:	Acta tropica 2023-08, Vol.244, p.106959-106959, Article 106959
Hauptverfasser:	Campagnaro, Gustavo Daniel, Lorenzon, Lucas Bigolin, Rodrigues, Mateus Augusto, Defina, Tânia Paula Aquino, Pinzan, Camila Figueiredo, Ferreira, Tiago Rodrigues, Cruz, Angela Kaysel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arginine Arginine - metabolism Arginine methylation cell lines gene expression In vivo infection Leishmania Leishmania major lymph Mammals metabolism Methylation Mice parasites Parasites - metabolism Protein arginine methyltransferase Protein-Arginine N-Methyltransferases - chemistry Protein-Arginine N-Methyltransferases - genetics Protein-Arginine N-Methyltransferases - metabolism type I protein arginine methyltransferase virulence
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