Hyperestrogenism is associated with sexual function impairment in men—findings from a cross‐sectional, real‐life study
Background Hyperestrogenism is believed to be harmful to male sexuality. We aimed to investigate the prevalence of and the impact of hyperestrogenism on sexual functioning in a cohort of men seeking medical attention for new‐onset erectile dysfunction. Materials and methods Data from 547 men seeking...
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| Veröffentlicht in: | Andrology (Oxford) 2024-01, Vol.12 (1), p.179-185 |
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| creator | Belladelli, Federico Boeri, Luca Fallara, Giuseppe Pozzi, Edoardo Corsini, Christian Cilio, Simone Capogrosso, Paolo D'Arma, Alessia Eisenberg, Michael L. Montorsi, Francesco Salonia, Andrea |
| description | Background
Hyperestrogenism is believed to be harmful to male sexuality. We aimed to investigate the prevalence of and the impact of hyperestrogenism on sexual functioning in a cohort of men seeking medical attention for new‐onset erectile dysfunction.
Materials and methods
Data from 547 men seeking first medical help for new‐onset erectile dysfunction at a single andrology center were analyzed. Patients were assessed with a thorough medical and sexual history. Comorbidities were scored with the Charlson comorbidity index. All patients completed the International index of erectile function; the International index of erectile function‐erectile function domain was categorized according to Cappelleri's criteria. Circulating hormones were measured in every patient. Hyperestrogenism was defined as estradiol levels >42.6 pg/mL (Tan et al., 2015). Descriptive statistics and logistic/linear regression models tested the association between hyperestrogenism and International index of erectile function domains score.
Results
Overall, 96 (17.6%) participants had serum estrogen levels suggestive of hyperestrogenism. Men with hyperestrogenism were older (median [interquartile range]: 46 [35–59] vs. 44 [31–56] years; p |
| doi_str_mv | 10.1111/andr.13470 |
| format | Article |
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Hyperestrogenism is believed to be harmful to male sexuality. We aimed to investigate the prevalence of and the impact of hyperestrogenism on sexual functioning in a cohort of men seeking medical attention for new‐onset erectile dysfunction.
Materials and methods
Data from 547 men seeking first medical help for new‐onset erectile dysfunction at a single andrology center were analyzed. Patients were assessed with a thorough medical and sexual history. Comorbidities were scored with the Charlson comorbidity index. All patients completed the International index of erectile function; the International index of erectile function‐erectile function domain was categorized according to Cappelleri's criteria. Circulating hormones were measured in every patient. Hyperestrogenism was defined as estradiol levels >42.6 pg/mL (Tan et al., 2015). Descriptive statistics and logistic/linear regression models tested the association between hyperestrogenism and International index of erectile function domains score.
Results
Overall, 96 (17.6%) participants had serum estrogen levels suggestive of hyperestrogenism. Men with hyperestrogenism were older (median [interquartile range]: 46 [35–59] vs. 44 [31–56] years; p < 0.001), had a higher rate of comorbidities (Charlson comorbidity index ≥1: 26.0% vs. 7.4%; p < 0.001), and higher serum total testosterone values (5.4 [5.2–8.0] vs. 4.3 [4.1–5.7] ng/mL; p = 0.01) than those with normal estradiol values. A higher prevalence of severe erectile dysfunction (135 [29.9%] vs. 47 [48.9%] men; p = 0.01) and of hypogonadism (22 [4.8%] vs. 6 [6.3%] men; p = 0.004) were found in men with hyperestrogenism. Serum estradiol levels were positively correlated with total testosterone levels (β = 0.26, p < 0.001) but negatively correlated with International index of erectile function‐orgasmic function (β = –0.24, p = 0.002) and International index of erectile function‐erectile function scores (β = –0.03, p < 0.001). When International index of erectile function scores was used to stratify erectile dysfunction patients, hyperestrogenism (odds ratio 2.44, p = 0.02) was associated with severe erectile dysfunction.
Conclusions
One out of five men seeking first medical help for erectile dysfunction showed elevated serum estradiol values suggestive of hyperestrogenism. Hyperestrogenism was associated with health‐significant comorbidities, orgasmic function impairment, and erectile dysfunction severity.</description><identifier>ISSN: 2047-2919</identifier><identifier>EISSN: 2047-2927</identifier><identifier>DOI: 10.1111/andr.13470</identifier><identifier>PMID: 37261881</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Comorbidity ; Erectile dysfunction ; estradiol ; estrogens ; sex hormones</subject><ispartof>Andrology (Oxford), 2024-01, Vol.12 (1), p.179-185</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology.</rights><rights>2023 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3930-c395a7452afd2830e56bac7a9315aad8916417073c3afbcec680114ec83bf6563</citedby><cites>FETCH-LOGICAL-c3930-c395a7452afd2830e56bac7a9315aad8916417073c3afbcec680114ec83bf6563</cites><orcidid>0000-0001-7872-2650 ; 0000-0002-0595-7165 ; 0000-0003-2347-9504 ; 0000-0002-2165-659X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fandr.13470$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fandr.13470$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37261881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belladelli, Federico</creatorcontrib><creatorcontrib>Boeri, Luca</creatorcontrib><creatorcontrib>Fallara, Giuseppe</creatorcontrib><creatorcontrib>Pozzi, Edoardo</creatorcontrib><creatorcontrib>Corsini, Christian</creatorcontrib><creatorcontrib>Cilio, Simone</creatorcontrib><creatorcontrib>Capogrosso, Paolo</creatorcontrib><creatorcontrib>D'Arma, Alessia</creatorcontrib><creatorcontrib>Eisenberg, Michael L.</creatorcontrib><creatorcontrib>Montorsi, Francesco</creatorcontrib><creatorcontrib>Salonia, Andrea</creatorcontrib><title>Hyperestrogenism is associated with sexual function impairment in men—findings from a cross‐sectional, real‐life study</title><title>Andrology (Oxford)</title><addtitle>Andrology</addtitle><description>Background
Hyperestrogenism is believed to be harmful to male sexuality. We aimed to investigate the prevalence of and the impact of hyperestrogenism on sexual functioning in a cohort of men seeking medical attention for new‐onset erectile dysfunction.
Materials and methods
Data from 547 men seeking first medical help for new‐onset erectile dysfunction at a single andrology center were analyzed. Patients were assessed with a thorough medical and sexual history. Comorbidities were scored with the Charlson comorbidity index. All patients completed the International index of erectile function; the International index of erectile function‐erectile function domain was categorized according to Cappelleri's criteria. Circulating hormones were measured in every patient. Hyperestrogenism was defined as estradiol levels >42.6 pg/mL (Tan et al., 2015). Descriptive statistics and logistic/linear regression models tested the association between hyperestrogenism and International index of erectile function domains score.
Results
Overall, 96 (17.6%) participants had serum estrogen levels suggestive of hyperestrogenism. Men with hyperestrogenism were older (median [interquartile range]: 46 [35–59] vs. 44 [31–56] years; p < 0.001), had a higher rate of comorbidities (Charlson comorbidity index ≥1: 26.0% vs. 7.4%; p < 0.001), and higher serum total testosterone values (5.4 [5.2–8.0] vs. 4.3 [4.1–5.7] ng/mL; p = 0.01) than those with normal estradiol values. A higher prevalence of severe erectile dysfunction (135 [29.9%] vs. 47 [48.9%] men; p = 0.01) and of hypogonadism (22 [4.8%] vs. 6 [6.3%] men; p = 0.004) were found in men with hyperestrogenism. Serum estradiol levels were positively correlated with total testosterone levels (β = 0.26, p < 0.001) but negatively correlated with International index of erectile function‐orgasmic function (β = –0.24, p = 0.002) and International index of erectile function‐erectile function scores (β = –0.03, p < 0.001). When International index of erectile function scores was used to stratify erectile dysfunction patients, hyperestrogenism (odds ratio 2.44, p = 0.02) was associated with severe erectile dysfunction.
Conclusions
One out of five men seeking first medical help for erectile dysfunction showed elevated serum estradiol values suggestive of hyperestrogenism. Hyperestrogenism was associated with health‐significant comorbidities, orgasmic function impairment, and erectile dysfunction severity.</description><subject>Comorbidity</subject><subject>Erectile dysfunction</subject><subject>estradiol</subject><subject>estrogens</subject><subject>sex hormones</subject><issn>2047-2919</issn><issn>2047-2927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp9kc9qGzEQxkVpSIKTSx6gCHIpIU71Z3elPYY0iQshgdKel7F25Crsah1pl9SQgx8hhzyhn6SynfrQQwehT4jffMzwEXLC2QVP9QV8HS64zBT7QA4Fy9RYlEJ93L15eUCOY3xkqfT6iH1yIJUouNb8kLxMFnMMGPvQzdC72FIXKcTYGQc91vTZ9b9oxN8DNNQO3vSu89S1c3ChRd9T52nS1fLNOl87P4vUhq6lQE3oYlwtXyNueqA5pwGhST-Ns0hjP9SLI7JnoYl4_K4j8vPm-sfVZHz3cPvt6vJubGQp2frOQWW5AFsLLRnmxRSMglLyHKDWJS8yrpiSRoKdGjSFZpxnaLSc2iIv5Ih83vrOQ_c0pGWr1kWDTQMeuyFWQgteyLIQKqGn_6CP3RDS-IkqmVRSaJ4n6mxLbbYMaKt5cC2ERcVZtY6lWsdSbWJJ8Kd3y2HaYr1D_4aQAL4Fnl2Di_9YVZf3X79vTf8Anmmb6w</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Belladelli, Federico</creator><creator>Boeri, Luca</creator><creator>Fallara, Giuseppe</creator><creator>Pozzi, Edoardo</creator><creator>Corsini, Christian</creator><creator>Cilio, Simone</creator><creator>Capogrosso, Paolo</creator><creator>D'Arma, Alessia</creator><creator>Eisenberg, Michael L.</creator><creator>Montorsi, Francesco</creator><creator>Salonia, Andrea</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7872-2650</orcidid><orcidid>https://orcid.org/0000-0002-0595-7165</orcidid><orcidid>https://orcid.org/0000-0003-2347-9504</orcidid><orcidid>https://orcid.org/0000-0002-2165-659X</orcidid></search><sort><creationdate>202401</creationdate><title>Hyperestrogenism is associated with sexual function impairment in men—findings from a cross‐sectional, real‐life study</title><author>Belladelli, Federico ; Boeri, Luca ; Fallara, Giuseppe ; Pozzi, Edoardo ; Corsini, Christian ; Cilio, Simone ; Capogrosso, Paolo ; D'Arma, Alessia ; Eisenberg, Michael L. ; Montorsi, Francesco ; Salonia, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3930-c395a7452afd2830e56bac7a9315aad8916417073c3afbcec680114ec83bf6563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Comorbidity</topic><topic>Erectile dysfunction</topic><topic>estradiol</topic><topic>estrogens</topic><topic>sex hormones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belladelli, Federico</creatorcontrib><creatorcontrib>Boeri, Luca</creatorcontrib><creatorcontrib>Fallara, Giuseppe</creatorcontrib><creatorcontrib>Pozzi, Edoardo</creatorcontrib><creatorcontrib>Corsini, Christian</creatorcontrib><creatorcontrib>Cilio, Simone</creatorcontrib><creatorcontrib>Capogrosso, Paolo</creatorcontrib><creatorcontrib>D'Arma, Alessia</creatorcontrib><creatorcontrib>Eisenberg, Michael L.</creatorcontrib><creatorcontrib>Montorsi, Francesco</creatorcontrib><creatorcontrib>Salonia, Andrea</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belladelli, Federico</au><au>Boeri, Luca</au><au>Fallara, Giuseppe</au><au>Pozzi, Edoardo</au><au>Corsini, Christian</au><au>Cilio, Simone</au><au>Capogrosso, Paolo</au><au>D'Arma, Alessia</au><au>Eisenberg, Michael L.</au><au>Montorsi, Francesco</au><au>Salonia, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperestrogenism is associated with sexual function impairment in men—findings from a cross‐sectional, real‐life study</atitle><jtitle>Andrology (Oxford)</jtitle><addtitle>Andrology</addtitle><date>2024-01</date><risdate>2024</risdate><volume>12</volume><issue>1</issue><spage>179</spage><epage>185</epage><pages>179-185</pages><issn>2047-2919</issn><eissn>2047-2927</eissn><abstract>Background
Hyperestrogenism is believed to be harmful to male sexuality. We aimed to investigate the prevalence of and the impact of hyperestrogenism on sexual functioning in a cohort of men seeking medical attention for new‐onset erectile dysfunction.
Materials and methods
Data from 547 men seeking first medical help for new‐onset erectile dysfunction at a single andrology center were analyzed. Patients were assessed with a thorough medical and sexual history. Comorbidities were scored with the Charlson comorbidity index. All patients completed the International index of erectile function; the International index of erectile function‐erectile function domain was categorized according to Cappelleri's criteria. Circulating hormones were measured in every patient. Hyperestrogenism was defined as estradiol levels >42.6 pg/mL (Tan et al., 2015). Descriptive statistics and logistic/linear regression models tested the association between hyperestrogenism and International index of erectile function domains score.
Results
Overall, 96 (17.6%) participants had serum estrogen levels suggestive of hyperestrogenism. Men with hyperestrogenism were older (median [interquartile range]: 46 [35–59] vs. 44 [31–56] years; p < 0.001), had a higher rate of comorbidities (Charlson comorbidity index ≥1: 26.0% vs. 7.4%; p < 0.001), and higher serum total testosterone values (5.4 [5.2–8.0] vs. 4.3 [4.1–5.7] ng/mL; p = 0.01) than those with normal estradiol values. A higher prevalence of severe erectile dysfunction (135 [29.9%] vs. 47 [48.9%] men; p = 0.01) and of hypogonadism (22 [4.8%] vs. 6 [6.3%] men; p = 0.004) were found in men with hyperestrogenism. Serum estradiol levels were positively correlated with total testosterone levels (β = 0.26, p < 0.001) but negatively correlated with International index of erectile function‐orgasmic function (β = –0.24, p = 0.002) and International index of erectile function‐erectile function scores (β = –0.03, p < 0.001). When International index of erectile function scores was used to stratify erectile dysfunction patients, hyperestrogenism (odds ratio 2.44, p = 0.02) was associated with severe erectile dysfunction.
Conclusions
One out of five men seeking first medical help for erectile dysfunction showed elevated serum estradiol values suggestive of hyperestrogenism. Hyperestrogenism was associated with health‐significant comorbidities, orgasmic function impairment, and erectile dysfunction severity.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37261881</pmid><doi>10.1111/andr.13470</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7872-2650</orcidid><orcidid>https://orcid.org/0000-0002-0595-7165</orcidid><orcidid>https://orcid.org/0000-0003-2347-9504</orcidid><orcidid>https://orcid.org/0000-0002-2165-659X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Comorbidity Erectile dysfunction estradiol estrogens sex hormones |
| title | Hyperestrogenism is associated with sexual function impairment in men—findings from a cross‐sectional, real‐life study |
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