Cu2+-pyropheophorbide-a-cystine conjugate-mediated multifunctional mesoporous silica nanoparticles for photo-chemodynamic therapy/GSH depletion combined with immunotherapy cancer

[Display omitted] •Hyaluronic acid modified Cu2+-Pyropheophorbide-a-Cystine conjugate (HSCuPPaCC) were synthesized.•HSCuPPaCC could efficiently doubly consume glutathione, amplify tumor cellular ROS levels, overcome tumor hypoxia and inhibite HIF-1α expression.•HSCuPPaCC could be preferentially enri...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of pharmaceutics 2023-06, Vol.640, p.123002-123002, Article 123002
Hauptverfasser:	Xu, Haiying, Su, Zhongping, Zhang, Hui, Zhang, Ying, Bao, Yujun, Zhang, Huanli, Wu, Xiaodan, Yan, Rui, Wang, Zhiqiang, Jin, Yingxue
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti tumor Deplete GSH Immune checkpoint blocking Synergistic therapy Targeting specific response
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!