Everything OLD is new again: How structural, functional, and bioinformatic advances have redefined a neglected nuclease family

Overcoming lysogenization defect (OLD) proteins are a conserved family of ATP‐powered nucleases that function in anti‐phage defense. Recent bioinformatic, genetic, and crystallographic studies have yielded new insights into the structure, function, and evolution of these enzymes. Here we review thes...

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Veröffentlicht in:	Molecular microbiology 2023-08, Vol.120 (2), p.122-140
Hauptverfasser:	Dot, Elena Wanvig, Thomason, Lynn C., Chappie, Joshua S.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC ATPase Crystal defects Crystallography Gabija Lysogenization Nuclease OLD nuclease PARIS phage defense Phages retron Septu Structure-function relationships Taxonomy Toprim
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