Exploring Diversity through Dimerization in Natural Products by a Rational Tandem Mass-Based Molecular Network Strategy

The step- and atom-efficient dimerization strategy is frequently used in nature to build structural complexity and diversity. We propose the rationale and structural features of the versatile monomers that are responsible for “diversity through dimerization”. Using 5-FAM-maleimide combined with a UH...

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Veröffentlicht in:	Organic letters 2023-06, Vol.25 (22), p.4016-4021
Hauptverfasser:	Li, Li, Wang, Yuezhou, Chen, Naixin, Li, Xiaoyang, Li, Hanpeng, Jin, Ling, Ou, Yixin, Kong, Xiang-Jian, Cao, Shugeng, Xu, Qingyan, Wu, Xiaobing, Han, Jianyong, Deng, Xianming
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Sprache:	eng
Schlagworte:	Biological Products - chemistry Dimerization Fungi Tandem Mass Spectrometry
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creator	Li, Li Wang, Yuezhou Chen, Naixin Li, Xiaoyang Li, Hanpeng Jin, Ling Ou, Yixin Kong, Xiang-Jian Cao, Shugeng Xu, Qingyan Wu, Xiaobing Han, Jianyong Deng, Xianming
description	The step- and atom-efficient dimerization strategy is frequently used in nature to build structural complexity and diversity. We propose the rationale and structural features of the versatile monomers that are responsible for “diversity through dimerization”. Using 5-FAM-maleimide combined with a UHPLC–MS/MS–FBMN workflow, we successfully identified a diverse set of dimeric natural products from fungus Panus rudis F01315, in which all four complex 4′5-ring scaffolds are derived from one monomeric epoxyquinol and endowed with functional diversity.
doi_str_mv	10.1021/acs.orglett.3c01038
format	Article
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subjects	Biological Products - chemistry Dimerization Fungi Tandem Mass Spectrometry
title	Exploring Diversity through Dimerization in Natural Products by a Rational Tandem Mass-Based Molecular Network Strategy
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