Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli

Antimicrobial resistance (AMR) crisis urges the development of new antibiotics. In the present work, we for the first time used bio-affinity ultrafiltration combined with HPLC-MS (UF-HPLC-MS) to examine the interaction between the outer membrane β-barrel proteins and natural products. Our results sh...

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Veröffentlicht in:	Biochemical and biophysical research communications 2023-08, Vol.668, p.90-95
Hauptverfasser:	Wei, Liangwan, Wang, Zhe, Chu, Yindi, Cai, Kun, Li, Wei, Huang, Piying, Qin, Youcai, Liu, Dailin, Zhuang, Xiaocui, Guo, Mingquan, Song, Xinbo, Fan, Enguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial resistance Assembly function Bacterial Outer Membrane Proteins - metabolism Chalcones - pharmacology Escherichia coli - metabolism Escherichia coli Proteins - metabolism Licochalcone A Protein Folding The outer membrane permeability β-barrel assembly machinery
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